Zobrazeno 1 - 10
of 64
pro vyhledávání: '"Aleš Tichý"'
Autor:
Aleš Tichý, Richard Saibert
Publikováno v:
Vojenské rozhledy, Vol 32, Iss 1, Pp 98-117 (2023)
The article deals with the evaluation of current possibilities of medical support capabilities in the area of Chemical, Biological, Radiological and Nuclear Defence. The evaluation of national strategic documents shows that the area of providing care
Externí odkaz:
https://doaj.org/article/fcf3d0cc53fa4bfb97714dffdd6010fe
Autor:
Jan Bureš, Darina Kohoutová, Jaroslav Květina, Věra Radochová, Michal Pavlík, Aleš Tichý, Stanislav Rejchrt, Marcela Kopáčová, Tomáš Douda, David Vysloužil, Jaroslav Pejchal
Publikováno v:
Acta Medica, Vol 64, Iss 2, Pp 85-90 (2021)
Background: Gastrointestinal injury caused by dextran sodium sulphate (DSS) is a reliable porcine experimental model of inflammatory bowel disease (IBD). The purpose of this study was to evaluate the effect of probiotic Lactobacillus casei DN 114001
Externí odkaz:
https://doaj.org/article/d4e1525929914fe689479c8d684beb9c
Autor:
Lourdes Cruz-Garcia, Grainne O’Brien, Botond Sipos, Simon Mayes, Aleš Tichý, Igor Sirák, Marie Davídková, Markéta Marková, Daniel J. Turner, Christophe Badie
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 21, p 7851 (2020)
Following cell stress such as ionising radiation (IR) exposure, multiple cellular pathways are activated. We recently demonstrated that ferredoxin reductase (FDXR) has a remarkable IR-induced transcriptional responsiveness in blood. Here, we provided
Externí odkaz:
https://doaj.org/article/a2c7ba0be4ca4cebb13e7cd78bba75f7
Autor:
Barbora Šalovská, Hana Janečková, Ivo Fabrik, Radana Karlíková, Lucie Čecháková, Martin Ondrej, Marek Link, David Friedecký, Aleš Tichý
Publikováno v:
PLoS ONE, Vol 13, Iss 7, p e0199349 (2018)
Current anti-cancer strategy takes advantage of tumour specific abnormalities in DNA damage response to radio- or chemo-therapy. Inhibition of the ATR/Chk1 pathway has been shown to be synthetically lethal in cells with high levels of oncogene-induce
Externí odkaz:
https://doaj.org/article/b33611cc1f7e4cc3ba499710b069781a
Autor:
Barbora Šalovská, Ivo Fabrik, Kamila Ďurišová, Marek Link, Jiřina Vávrová, Martina Řezáčová, Aleš Tichý
Publikováno v:
International Journal of Molecular Sciences, Vol 15, Iss 7, Pp 12007-12026 (2014)
DNA damaging agents such as ionizing radiation or chemotherapy are frequently used in oncology. DNA damage response (DDR)—triggered by radiation-induced double strand breaks—is orchestrated mainly by three Phosphatidylinositol 3-kinase-related ki
Externí odkaz:
https://doaj.org/article/8ce069f05b3546da89e01d2e7fa5020b
Autor:
Aleš Tichý, Eva Novotná, Kamila Ďurišová, Barbora Šalovská, Radka Sedlaříková, Jaroslav Pejchal, Lenka Zárybnická, Jiřina Vávrová, Zuzana Šinkorová, Martina Řezáčová
Publikováno v:
Acta Medica, Vol 55, Iss 2, Pp 66-73 (2012)
In this paper we describe the influence of NU7026, a specific inhibitor of DNA-dependent protein kinase, phosphoinositide 3-kinase, and ATM-kinase on molecular and cellular mechanisms triggered by ionising irradiation in human T-lymphocyte leukaemic
Externí odkaz:
https://doaj.org/article/863ee596f9ea4c379f25b2410648c158
Publikováno v:
Acta Medica, Vol 53, Iss 1, Pp 13-17 (2010)
Ataxia-telangiectasia mutated kinase (ATM) is a DNA damage-inducible protein kinase, which phosphorylates plethora of substrates participating in DNA damage response. ATM significance for the cell faith is undeniable, since it regulates DNA repair, c
Externí odkaz:
https://doaj.org/article/ea74787363804a54966b18653aaed881
Autor:
Aleš Tichý
Publikováno v:
Acta Medica, Vol 49, Iss 1, Pp 13-18 (2006)
Programmed cell death, apoptosis, plays an integral role in a variety of biological events, e.g. morphogenesis, removal of unwanted or harmful cells, tissue homeostasis etc. Members of the Bcl-2 family have been described as the key players in the re
Externí odkaz:
https://doaj.org/article/fd1a3edd15cb48d8ac2fa6dd94e1942d
Publikováno v:
International Journal of Radiation Biology. :1-19
Autor:
Zuzana, Šinkorová, Anna, Lierová, Alžběta, Filipová, Jana, Čížková, Aleš, Tichý, Jaroslav, Pejchal, Marcela, Milanová, Zdena, Vilasová, Lenka, Andrejsová
Publikováno v:
Radiation Protection Dosimetry. 198:521-526
The JC-1 dye is widely used in apoptosis studies to monitor mitochondrial health. The probe was tested in vitro on two established cell lines and peripheral porcine blood lymphocytes after gamma irradiation (IR) to assess its potential in biodosimetr