Zobrazeno 1 - 10
of 166
pro vyhledávání: '"Aleš Hampl"'
Autor:
Tereza Smutná, Jana Dumková, Daniela Kristeková, Markéta Laštovičková, Adriena Jedličková, Lucie Vrlíková, Bohumil Dočekal, Lukáš Alexa, Hana Kotasová, Vendula Pelková, Zbyněk Večeřa, Kamil Křůmal, Jiří Petráš, Pavel Coufalík, Dalibor Všianský, Samuel Záchej, Dominik Pinkas, Jan Vondráček, Aleš Hampl, Pavel Mikuška, Marcela Buchtová
Publikováno v:
Particle and Fibre Toxicology, Vol 19, Iss 1, Pp 1-28 (2022)
Abstract Background Inhalation of lead oxide nanoparticles (PbO NPs), which are emitted to the environment by high-temperature technological processes, heavily impairs target organs. These nanoparticles pass through the lung barrier and are distribut
Externí odkaz:
https://doaj.org/article/a358cefb521242e29da92c9c03770d3b
Autor:
Sára Lenárt, Peter Lenárt, Lucia Knopfová, Hana Kotasová, Vendula Pelková, Veronika Sedláková, Ondřej Vacek, Jana Pokludová, Vladimír Čan, Jan Šmarda, Karel Souček, Aleš Hampl, Petr Beneš
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-15 (2022)
Abstract TACSTD2 encodes a transmembrane glycoprotein Trop2 commonly overexpressed in carcinomas. While the Trop2 protein was discovered already in 1981 and first antibody–drug conjugate targeting Trop2 were recently approved for cancer therapy, th
Externí odkaz:
https://doaj.org/article/ec7ff7a2fa694aecb1011c9f0a61909f
Autor:
Stanislav Drápela, Prashant Khirsariya, Wytske M. vanWeerden, Radek Fedr, Tereza Suchánková, Diana Búzová, Jan Červený, Aleš Hampl, Martin Puhr, William R. Watson, Zoran Culig, Lumír Krejčí, Kamil Paruch, Karel Souček
Publikováno v:
Molecular Oncology, Vol 14, Iss 10, Pp 2487-2503 (2020)
As treatment options for patients with incurable metastatic castration‐resistant prostate cancer (mCRPC) are considerably limited, novel effective therapeutic options are needed. Checkpoint kinase 1 (CHK1) is a highly conserved protein kinase impli
Externí odkaz:
https://doaj.org/article/245939cd91484669b8fffb8ca46e74cb
Autor:
Zuzana Trebichalská, Jakub Javůrek, Martina Tatíčková, Drahomíra Kyjovská, Soňa Kloudová, Pavel Otevřel, Aleš Hampl, Zuzana Holubcová
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
The egg plays a pivotal role in the reproduction of our species. Nevertheless, its fundamental biology remains elusive. Transmission electron microscopy is traditionally used to inspect the ultrastructure of female gametes. However, two-dimensional m
Externí odkaz:
https://doaj.org/article/a3c7b52f32dc4d7995b2b2d370a7a9ef
Autor:
Zuzana Kahounová, Eva Slabáková, Lucia Binó, Ján Remšík, Radek Fedr, Jan Bouchal, Daniela Kurfűrstová, Radek Vrtěl, Vladimír Študent, Lucie Jurečková, Volodymyr Porokh, Aleš Hampl, Karel Souček
Publikováno v:
Stem Cell Research, Vol 33, Iss , Pp 255-259 (2018)
A human induced pluripotent stem cell line was generated from cancer-associated fibroblasts of a 68-years old patient with diagnosed prostate adenocarcinoma (PCa). The fibroblast cell line was reprogrammed with Epi5™ Episomal iPSC Reprogramming Kit
Externí odkaz:
https://doaj.org/article/ff7f398ed78e4e059a1dbe047213f717
Autor:
Zuzana Kahounová, Ján Remšík, Radek Fedr, Jan Bouchal, Alena Mičková, Eva Slabáková, Lucia Binó, Aleš Hampl, Karel Souček
Publikováno v:
Stem Cell Research, Vol 46, Iss , Pp 101844- (2020)
Deciphering the properties of adult stem cells is crucial for understanding of their role in healthy tissue and in cancer progression as well. Both stem cells and cancer stem cells have shown association with epithelial-to-mesenchymal transition (EMT
Externí odkaz:
https://doaj.org/article/86a34fde54fb4d0281b36574a5423019
Autor:
Gerardo Vázquez-Gómez, Martina Karasová, Zuzana Tylichová, Markéta Kabátková, Aleš Hampl, Jason Matthews, Jiří Neča, Miroslav Ciganek, Miroslav Machala, Jan Vondráček
Publikováno v:
Cells, Vol 11, Iss 4, p 707 (2022)
Apart from its role in the metabolism of carcinogens, the aryl hydrocarbon receptor (AhR) has been suggested to be involved in the control of inflammatory responses within the respiratory tract. However, the mechanisms responsible for this are only p
Externí odkaz:
https://doaj.org/article/aecd33d6caf949ad865d7b0f561df282
Autor:
Anna Kotrbová, Karel Štěpka, Martin Maška, Jakub Jozef Pálenik, Ladislav Ilkovics, Dobromila Klemová, Marek Kravec, František Hubatka, Zankruti Dave, Aleš Hampl, Vítězslav Bryja, Pavel Matula, Vendula Pospíchalová
Publikováno v:
Journal of Extracellular Vesicles, Vol 8, Iss 1 (2019)
Extracellular vesicles (EVs) function as important conveyers of information between cells and thus can be exploited as drug delivery systems or disease biomarkers. Transmission electron microscopy (TEM) remains the gold standard method for visualisat
Externí odkaz:
https://doaj.org/article/e8422357174045708c3588dd84e57d8e
Autor:
Zuzana Kahounová, Eva Slabáková, Lucia Binó, Ján Remšík, Radek Fedr, Jan Bouchal, Radek Vrtěl, Lucie Jurečková, Volodymyr Porokh, Darja Páralová, Aleš Hampl, Karel Souček
Publikováno v:
Stem Cell Research, Vol 35, Iss , Pp - (2019)
Human induced pluripotent stem cell line was generated from commercially available primary human prostate fibroblasts HPrF derived from a fetus, aged 18–24 weeks of gestation. The fibroblast cell line was reprogrammed with Yamanaka factors (OCT4, S
Externí odkaz:
https://doaj.org/article/f112efb59bb94fadb1795db7605ea344
Publikováno v:
Stem Cells International, Vol 2019 (2019)
Tumor necrosis factor-related apoptosis-inducing ligand—TRAIL—is a protein operating as a ligand capable of inducing apoptosis particularly in cancerously transformed cells, while normal healthy cells are typically nonresponsive. We have previous
Externí odkaz:
https://doaj.org/article/ba9024e958574e6aa55c88b26059e840