Identification of Lipstatin-Producing Ability in Streptomyces virginiae CBS 314.55 Using Dereplication Approach

Autor: Gordan Sladič, Matilda Urukalo, Matjaž Kirn, Urška Lešnik, Vasilka Magdevska, Neda Benički, Mitja Pelko, Aleš Gasparič, Peter Raspor, Tomaž Polak, Štefan Fujs, Paul A. Hoskisson, Hrvoje Petković

Publikováno v: Food Technology and Biotechnology, Vol 52, Iss 3, Pp 276-284 (2014)

Streptomyces species are prolific producers of bioactive metabolites, such as β-lactone-containing lipstatin produced by Streptomyces toxytricini, an intermediate used in semi-synthetic process for production of anti-obesity drug orlistat. Understan

Externí odkaz: https://doaj.org/article/890df97d505e42ff8feed02722005684

Development, optimization and scale-up of stereo-selective enzymatic Baeyer–Villiger oxidation of pyrmetazole to esomeprazole active ingredient in an industrial-scale slurry reactor

Autor: Blaž Likozar, Marko Bitenc, Andrej Pohar, Aleš Gasparič, Marko Herga

Publikováno v: Journal of Industrial and Engineering Chemistry. 72:214-221

An industrial-scale stereo-selective enzymatic oxidation process for the conversion of pyrmetazole to esomeprazole was developed and optimized. Slurry-to-slurry stages are highly demanding synthetic operations due to several deteriorating factors: co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bd2b8915c5d08b9e6d583e4f425a193b
https://doi.org/10.1016/j.jiec.2018.12.020

Identification of lipstatin-producing ability in Streptomyces Virginiae CBS 314.55 using dereplication approach

Autor: Gordan Sladič, Matilda Urukalo, Matjaž Kirn, Urška Lešnik, Vasilka Magdevska, Neda Benički, Mitja Pelko, Aleš Gasparič, Peter Raspor, Tomaž Polak, Štefan Fujs, Paul Hoskisson, Hrvoje Petković

Publikováno v: University of Strathclyde
Food Technology and Biotechnology
Volume 52
Issue 3
Food Technology and Biotechnology, Vol 52, Iss 3, Pp 276-284 (2014)

Streptomicete su poznate kao bogat izvor bioaktivnih metabolita, poput sekundarnog metabolita lipstatina, koji ima vrlo karakterističnu strukturu β-laktona, a upotrebljava se kao intermedijar u proizvodnji lijeka za mršavljenje, komercijalnog nazi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::8b4c4d02e3cbad6e94f67ef41f95c60a
https://pureportal.strath.ac.uk/en/publications/6bd3c1cb-e9fd-4921-a7e4-922594f08654