Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Aleš Cvekl"'
Autor:
Aleš Cvekl, Michael John Camerino
Publikováno v:
Cells, Vol 11, Iss 21, p 3516 (2022)
In vitro differentiation of human pluripotent stem cells (hPSCs) into specialized tissues and organs represents a powerful approach to gain insight into those cellular and molecular mechanisms regulating human development. Although normal embryonic e
Externí odkaz:
https://doaj.org/article/cf1a08b26cd34afaa4b80dfc526dd8f9
Publikováno v:
Epigenetics & Chromatin, Vol 17, Iss 1, Pp 1-26 (2024)
Abstract Background Nuclear organization of interphase chromosomes involves individual chromosome territories, “open” and “closed” chromatin compartments, topologically associated domains (TADs) and chromatin loops. The DNA- and RNA-binding t
Externí odkaz:
https://doaj.org/article/4e3f3cede6224dab86f82a3f9d3a5aaa
Publikováno v:
Epigenetics & Chromatin, Vol 16, Iss 1, Pp 1-30 (2023)
Abstract Background Cellular differentiation is marked by temporally and spatially coordinated gene expression regulated at multiple levels. DNA methylation represents a universal mechanism to control chromatin organization and its accessibility. Cyt
Externí odkaz:
https://doaj.org/article/093a4ede69ba44038c01f5d4de94a52e
Publikováno v:
Biomolecules, Vol 13, Iss 4, p 693 (2023)
Recent advances in next-generation sequencing and data analysis have provided new gateways for identification of novel genome-wide genetic determinants governing tissue development and disease. These advances have revolutionized our understanding of
Externí odkaz:
https://doaj.org/article/7643bf89b26d416e9940bfed6d99352b
Publikováno v:
Gene. 156:277-281
The 5′-end of the duck βA-globin promoter contains a protein binding site BS-3/Spl, the A + T-rich part of which could be involved in DNA bending. Plasmids were constructed using the pBend2 plasmid containing BS-3/Spl. Circular permutation analysi
Publikováno v:
Epigenetics & Chromatin, Vol 12, Iss 1, Pp 1-23 (2019)
Abstract Background Promoters and enhancers are cis-regulatory DNA sequences that control specificity and quantity of transcription. Both are rich on clusters of cis-acting sites that interact with sequence-specific DNA-binding transcription factors
Externí odkaz:
https://doaj.org/article/064c6629742d439a8e7b1a3a80a33126
Publikováno v:
Open Biology, Vol 9, Iss 12 (2019)
Gata3 is a DNA-binding transcription factor involved in cellular differentiation in a variety of tissues including inner ear, hair follicle, kidney, mammary gland and T-cells. In a previous study in 2009, Maeda et al. (Dev. Dyn. 238, 2280–2291; doi
Externí odkaz:
https://doaj.org/article/2a0efc72038944f498ff2c1289086ffd
Autor:
Mirunalini Ravichandran, Run Lei, Qin Tang, Yilin Zhao, Joun Lee, Liyang Ma, Stephanie Chrysanthou, Benjamin M. Lorton, Ales Cvekl, David Shechter, Deyou Zheng, Meelad M. Dawlaty
Publikováno v:
Cell Reports, Vol 28, Iss 8, Pp 1993-2003.e5 (2019)
Summary: The Retinoid inducible nuclear factor (Rinf), also known as CXXC5, is a nuclear protein, but its functions in the context of the chromatin are poorly defined. We find that in mouse embryonic stem cells (mESCs), Rinf binds to the chromatin an
Externí odkaz:
https://doaj.org/article/37bdf7b27f3442329691914c393ef885
Publikováno v:
Biology Open, Vol 7, Iss 12 (2018)
Gene regulation by enhancers is important for precise temporal and spatial gene expression. Enhancers can drive gene expression regardless of their location, orientation or distance from the promoter. Changes in chromatin conformation and chromatin l
Externí odkaz:
https://doaj.org/article/b4861c36ece74b02880ad73178d686f4
Publikováno v:
Stem Cell Reports, Vol 6, Iss 5, Pp 743-756 (2016)
In this study we dissected retinal organoid morphogenesis in human embryonic stem cell (hESC)-derived cultures and established a convenient method for isolating large quantities of retinal organoids for modeling human retinal development and disease.
Externí odkaz:
https://doaj.org/article/501fd9cd47104c5191fd7fabfa9eeabb