Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Aleš Žula"'
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 20, Iss , Pp 5420-5429 (2022)
For the development of concentrated monoclonal antibody formulations for subcutaneous administration, the main challenge is the high viscosity of the solutions. To compensate for this, viscosity reducing agents are commonly used as excipients. Here,
Externí odkaz:
https://doaj.org/article/a635c0e9d2914fa29fff68bb75575823
Autor:
Steve Peigneur, Aleš Žula, Nace Zidar, Fiona Chan-Porter, Robert Kirby, David Madge, Janez Ilaš, Danijel Kikelj, Jan Tytgat
Publikováno v:
Marine Drugs, Vol 12, Iss 4, Pp 2132-2143 (2014)
Clathrodin is a marine alkaloid and believed to be a modulator of voltage-gated sodium (NaV) channels. Since there is an urgent need for small molecule NaV channel ligands as novel therapeutics, clathrodin could represent an interesting lead compound
Externí odkaz:
https://doaj.org/article/ae4d9687a1d8427f8427040fc63d88ca
Publikováno v:
Marine Drugs, Vol 16, Iss 11, p 413 (2018)
Spumigins are marine natural products derived from cyanobacteria Nodularia spumigena, which mimics the structure of the d-Phe-Pro-Arg sequence and is crucial for binding to the active site of serine proteases thrombin and factor Xa. Biological evalua
Externí odkaz:
https://doaj.org/article/41fae373a3084d8db5b914b45694911c
Publikováno v:
Marine drugs, vol. 16, no. 11, 413, 2018.
Marine Drugs
Marine drugs, str. 1-19 : Ilustr., Vol. 16, iss. 11, Nov. 2018
COBISS-ID: 23578841
Volume 16
Issue 11
Marine Drugs, Vol 16, Iss 11, p 413 (2018)
Marine Drugs
Marine drugs, str. 1-19 : Ilustr., Vol. 16, iss. 11, Nov. 2018
COBISS-ID: 23578841
Volume 16
Issue 11
Marine Drugs, Vol 16, Iss 11, p 413 (2018)
Spumigins are marine natural products derived from cyanobacteria Nodularia spumigena, which mimics the structure of the d-Phe-Pro-Arg sequence and is crucial for binding to the active site of serine proteases thrombin and factor Xa. Biological evalua
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bac1fa69fa66445a362248acdb80e875
https://repozitorij.uni-lj.si/Dokument.php?id=141042&dn=
https://repozitorij.uni-lj.si/Dokument.php?id=141042&dn=
Autor:
Nace Zidar, Janez Ilaš, Aleš Žula, Steve Peigneur, Jan Tytgat, Robert W. Kirby, Danijel Kikelj, Marc Rogers, Tihomir Tomašič, Lucija Peterlin Mašič
Publikováno v:
European Journal of Medicinal Chemistry. 139:232-241
We have prepared three alkaloids from the Agelas sponges, clathrodin, hymenidin and oroidin, and a series of their synthetic analogues, and evaluated their inhibitory effect against six isoforms of the K v 1 subfamily of voltage-gated potassium chann
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a27b3556df1399aafba9b439539ea92
https://doi.org/10.1016/j.ejmech.2017.08.015
https://doi.org/10.1016/j.ejmech.2017.08.015
Publikováno v:
Medicinal Research Reviews. 38:426-503
Due to the widespread emergence of resistant bacterial strains, an urgent need for the development of new antibacterial agents with novel modes of action has emerged. The discovery of naturally occurring monocyclic β-lactams in the late 1970s, mainl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90fdfd6bbcffcbf0ae29258040935380
https://doi.org/10.1002/med.21443
https://doi.org/10.1002/med.21443
Publikováno v:
Journal of Heterocyclic Chemistry. 53:345-355
The 2-aminoimidazole (2-AI) ring is used widely as a building block in the design of new biologically active compounds, because of its good physico-chemical properties and potent activity in various test systems. Many marine alkaloids contain the 2-A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4df3f02dddc7e48fea27210d3b2d5b38
https://doi.org/10.1002/jhet.2415
https://doi.org/10.1002/jhet.2415
Publikováno v:
Mini-Reviews in Medicinal Chemistry. 13:1921-1943
2-Aminoimidazole skeleton represents a unique building block which is often used in the design of modulators of different targets and small molecule drugs. Alkaloids isolated from marine sponges are known to be one of the most common sources of the 2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82cfa0bc5f4898949ec661bfe3281dfe
https://doi.org/10.2174/1389557511313130007
https://doi.org/10.2174/1389557511313130007
Publikováno v:
Tetrahedron Letters
A convenient strategy for the scalable synthesis of the 2-aminoimidazole alkaloids, clathrodin, oroidin, and hymenidin derived from marine Agelas species and their analogs possessing a saturated or unsaturated linker moiety is described. The key inte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1dc3625904ebf10b7437b77fa01ada0
https://doi.org/10.1016/j.tetlet.2014.05.087
https://doi.org/10.1016/j.tetlet.2014.05.087
Autor:
Genevieve Ubeaud-Sequier, Žiga Jakopin, Danijel Kikelj, Christian D. Muller, Janez Ilaš, Nace Zidar, Sanja Vrbek, Lucija Peterlin Mašič, Aleš Žula, Jean Peluso, Tihomir Tomašič, Marko Anderluh, Dominik Nabergoj, Marko Jukič, Marija Sollner Dolenc, Žiga Hodnik
Publikováno v:
MedChemComm
MedChemComm, Royal Society of Chemistry, 2015, 6 (1), pp.105-110. ⟨10.1039/c4md00286e⟩
MedChemComm, Royal Society of Chemistry, 2015, 6 (1), pp.105-110. ⟨10.1039/c4md00286e⟩
The marine alkaloids clathrodin, oroidin, and hymenidin, which were isolated from Agelas sponges, possess diverse biological activities. Herein, we describe the design of a library of their analogues and the evaluation of their apoptosis-inducing act
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5844a81bbf82b10f12771329dec867c9
https://hal.archives-ouvertes.fr/hal-02106940
https://hal.archives-ouvertes.fr/hal-02106940