Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Aldrin V. Vasco"'
Publikováno v:
ACS Omega, Vol 5, Iss 40, Pp 25505-25510 (2020)
Externí odkaz:
https://doaj.org/article/2eddb4b27f734c20906925a6ed8b7fc7
Autor:
Aldrin V. Vasco, Martina Brode, Yanira Méndez, Oscar Valdés, Daniel G. Rivera, Ludger A. Wessjohann
Publikováno v:
Molecules, Vol 25, Iss 4, p 811 (2020)
Antimicrobial resistance to conventional antibiotics and the limited alternatives to combat plant-threatening pathogens are worldwide problems. Antibiotic lipopeptides exert remarkable membrane activity, which usually is not prone to fast resistance
Externí odkaz:
https://doaj.org/article/166d7d0f83a0452788751f8c9ebe4145
Autor:
Raine Garrido, Mirelys Saenz, Yanira Méndez, Vicente Verez-Bencomo, Rocmira Perez-Nicado, Daniel G. Rivera, Ana R. Humpierre, Aldrin V. Vasco, Dagmar García-Rivera, Abel Zanuy, Yamilka Soroa-Milán, Bernhard Westermann, Darielys Santana-Mederos
Publikováno v:
Bioconjugate Chemistry. 31:2231-2240
Conjugate vaccines against encapsulated pathogens like Streptococcus pneumoniae face many challenges, including the existence of multiple serotypes with a diverse global distribution that constantly requires new formulations and higher coverage. Mult
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5460607915493e2b4a4e6cc4778c7d8
https://doi.org/10.1021/acs.bioconjchem.0c00423
https://doi.org/10.1021/acs.bioconjchem.0c00423
Quantitative NMR for the structural analysis of novel bivalent glycoconjugates as vaccine candidates
Autor:
Ana R. Humpierre, Abel Zanuy, Mirelys Saenz, Aldrin V. Vasco, Yanira Méndez, Bernhard Westermann, Félix Cardoso, Lauren Quintero, Darielys Santana, Vicente Verez, Yury Valdés, Daniel G. Rivera, Raine Garrido
Publikováno v:
Journal of pharmaceutical and biomedical analysis. 214
Novel unimolecular bivalent glycoconjugates were assembled combining several functionalized capsular polysaccharides of Streptococcus pneumoniae and Neisseria meningitidis to a carrier protein by using an effective strategy based on the Ugi 4-compone
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdf1a6bc48c926b7ee57ae3b2853ec8c
https://pubmed.ncbi.nlm.nih.gov/35338945
https://pubmed.ncbi.nlm.nih.gov/35338945
Publikováno v:
Methods in Molecular Biology ISBN: 9781071616888
Multicomponent reactions (MCRs) are recently expanding the plethora of solid-phase protocols for the synthesis and derivatization of peptides. Herein, we describe a solid-phase-compatible strategy based on MCRs as a powerful strategy for peptide cycl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::371a066476ac53fef43e4da22b8854c2
https://doi.org/10.1007/978-1-0716-1689-5_8
https://doi.org/10.1007/978-1-0716-1689-5_8
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2371
Multicomponent reactions (MCRs) are recently expanding the plethora of solid-phase protocols for the synthesis and derivatization of peptides. Herein, we describe a solid-phase-compatible strategy based on MCRs as a powerful strategy for peptide cycl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::594f7a65d9958014d33cb509babcbda6
https://pubmed.ncbi.nlm.nih.gov/34596847
https://pubmed.ncbi.nlm.nih.gov/34596847
Publikováno v:
Organic Letters. 21:7307-7310
A solid-phase approach including on-resin Ugi reactions was developed for the construction of β-hairpins. Various N-alkylated dipeptide fragments proved capable of aligning antiparallel β-sheets in...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::318e80185c8e95ca1e0f1bad4feb2da2
https://doi.org/10.1021/acs.orglett.9b02592
https://doi.org/10.1021/acs.orglett.9b02592
Autor:
Pedro A. Valiente, Maday Alonso del Rivero, Yoanna María Alvarez-Ginarte, Aldrin V. Vasco, Carmen Soto, Yanira Méndez, Tamara Rojas, Bernhard Westermann, Idalia Pérez, German De Armas, Lena de León, Jorge González-Bacerio, Maikel Izquierdo, William L. Scott, Mario E. Valdés-Tresanco, Daniel G. Rivera
Publikováno v:
European Journal of Medicinal Chemistry. 163:481-499
The Escherichia coli neutral M1-aminopeptidase (ePepN) is a novel target identified for the development of antimicrobials. Here we describe a solid-phase multicomponent approach which enabled the discovery of potent ePepN inhibitors. The on-resin pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d244d65777ecddd2c841f557b3608c2f
https://doi.org/10.1016/j.ejmech.2018.11.074
https://doi.org/10.1016/j.ejmech.2018.11.074
Autor:
Erik V. Van der Eycken, Manuel G. Ricardo, Daniel G. Rivera, Aldrin V. Vasco, Ludger A. Wessjohann
Solid-phase synthesis represents the methodological showcase for technological advances such as split-and-pool combinatorial chemistry and the automated synthesis of peptides, nucleic acids and polysaccharides. These strategies involve iterative coup
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::164e32e76422b1a950412ef69fbe1777
https://lirias.kuleuven.be/handle/123456789/666620
https://lirias.kuleuven.be/handle/123456789/666620
Autor:
Jochen Balbach, Stefan Gröger, Wolfgang Brandt, Carlos Pérez, Ludger A. Wessjohann, Celia G. Moya, Aldrin V. Vasco, Daniel G. Rivera
Publikováno v:
Organicbiomolecular chemistry. 18(20)
Stapled peptides derived from the Ugi macrocyclization comprise a special class of cyclopeptides with an N-substituted lactam bridge cross-linking two amino acid side chains. Herein we report a comprehensive analysis of the structural factors influen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f590403edec3dc90aaee20d267f9b341
https://pubmed.ncbi.nlm.nih.gov/32400808
https://pubmed.ncbi.nlm.nih.gov/32400808