Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Aldrin E Molero"'
Autor:
Giang D Nguyen, Solen Gokhan, Aldrin E Molero, Seung-Min Yang, Byung-Ju Kim, Arthur I Skoultchi, Mark F Mehler
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e96858 (2014)
H1 linker histone proteins are essential for the structural and functional integrity of chromatin and for the fidelity of additional epigenetic modifications. Deletion of H1c, H1d and H1e in mice leads to embryonic lethality by mid-gestation with a b
Externí odkaz:
https://doaj.org/article/1e0c99051a3441faac370874d1e16f6a
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e64368 (2013)
Huntington's disease (HD) is a neurodegenerative disorder caused by abnormal polyglutamine expansion in the amino-terminal end of the huntingtin protein (Htt) and characterized by progressive striatal and cortical pathology. Previous reports have sho
Externí odkaz:
https://doaj.org/article/d5471c28f13b41ddafe1883b6f55c73b
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e72698 (2013)
Huntington's disease (HD) is a neurodegenerative disease caused by abnormal polyglutamine expansion in the huntingtin protein (Htt). Although both Htt and the HD pathogenic mutation (mHtt) are implicated in early developmental events, their individua
Externí odkaz:
https://doaj.org/article/5dfc3b19ef6b4afe82a27403129b97e4
Autor:
Eduardo E. Arteaga-Bracho, Maria Gulinello, Michael L. Winchester, Nandini Pichamoorthy, Jenna R. Petronglo, Alicia D. Zambrano, Julio Inocencio, Chirstopher D. De Jesus, Joseph O. Louie, Solen Gokhan, Mark F. Mehler, Aldrin E. Molero
Publikováno v:
Neurobiology of Disease, Vol 96, Iss , Pp 144-155 (2016)
The mutation in huntingtin (mHtt) leads to a spectrum of impairments in the developing forebrain of Huntington's disease (HD) mouse models. Whether these developmental alterations are due to loss- or gain-of-function mechanisms and contribute to HD p
Externí odkaz:
https://doaj.org/article/033914eac2624c8087987ee040422140
Autor:
Aldrin E. Molero, Maria Gulinello, Christopher D. DeJesus, Hifza Ishtiaq, Nandini Pichamoorthy, Jenna R. Petronglo, Solen Gokhan, Mark F. Mehler, Michael L. Winchester, Eduardo E. Arteaga-Bracho, Stephen K. Young
Publikováno v:
The Journal of Neuroscience. 39:1892-1909
Emerging studies are providing compelling evidence that the pathogenesis of Huntington's disease (HD), a neurodegenerative disorder with frequent midlife onset, encompasses developmental components. Moreover, our previous studies using a hypomorphic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf5a77453fe69c44b2b5d4ad68929bbd
https://doi.org/10.1523/jneurosci.2443-18.2018
https://doi.org/10.1523/jneurosci.2443-18.2018
Autor:
Solen Gokhan, Mark F. Mehler, Chirstopher D. De Jesus, Michael L. Winchester, Alicia D. Zambrano, Jenna R. Petronglo, Aldrin E. Molero, Maria Gulinello, Eduardo E. Arteaga-Bracho, Julio F. Inocencio, Joseph O. Louie, Nandini Pichamoorthy
Publikováno v:
Neurobiology of Disease, Vol 96, Iss, Pp 144-155 (2016)
The mutation in huntingtin (mHtt) leads to a spectrum of impairments in the developing forebrain of Huntington's disease (HD) mouse models. Whether these developmental alterations are due to loss- or gain-of-function mechanisms and contribute to HD p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53c21c12af66d33cf9ab628350cbb5e1
http://www.sciencedirect.com/science/article/pii/S096999611630225X
http://www.sciencedirect.com/science/article/pii/S096999611630225X
Autor:
Maria Gulinello, Solen Gokhan, Michael L. Winchester, Christopher H. Chen, Aldrin E. Molero, Eduardo E. Arteaga-Bracho, Mark F. Mehler, Kamran Khodakhah, Nandini Pichamoorthy
Publikováno v:
Proceedings of the National Academy of Sciences. 113:5736-5741
Recent studies have identified impairments in neural induction and in striatal and cortical neurogenesis in Huntington's disease (HD) knock-in mouse models and associated embryonic stem cell lines. However, the potential role of these developmental a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76bc0d3338ed50911dbddf756b4f0853
https://doi.org/10.1073/pnas.1603871113
https://doi.org/10.1073/pnas.1603871113
Autor:
Joseph J. Abrajano, Mark F. Mehler, Shau Yu Yung, Aldrin E. Molero, Solen Gokhan, Jennifer Jurcsak
Publikováno v:
Proceedings of the National Academy of Sciences. 99:16273-16278
During cerebral cortical development, excitatory glutamatergic projection neurons are generated from neural stem cells intrinsic to the early embryonic cortical ventricular zone by a process of radial migration, whereas most inhibitory γ-aminobutyri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8ffc39c2c24444748e6e60d4bfec69d
https://doi.org/10.1073/pnas.232586699
https://doi.org/10.1073/pnas.232586699
Autor:
Tulio Sulbarán, Egle Silva, Gladys E. Maestre, Luis Falque, Aldrin E. Molero, María P. Gamero, Raquel Zambrano, Gloria Pino-Ramirez
Publikováno v:
Neuroepidemiology. 21:194-201
The Maracaibo Aging Study is a longitudinal, population-based, one-step multidisciplinary study of age-related diseases, with a particular focus on memory-related disorders, among subjects over 55 years living in a neighborhood of the city of Maracai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe1d77091eecee8b44ffa23b35d82837
https://doi.org/10.1159/000059524
https://doi.org/10.1159/000059524
Publikováno v:
Neuroscience Letters. 307:5-8
An ongoing longitudinal study in Maracaibo, Venezuela, examined the interaction between apolipoprotein E (APOE) genotypes and Alzheimer's disease (AD) and vascular dementia (VD), evaluating age and gender as potential modifiers of risk. Overall, carr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15531a02e010871d7b1ec0542e906f17
https://doi.org/10.1016/s0304-3940(01)01911-5
https://doi.org/10.1016/s0304-3940(01)01911-5