Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Aldous, Suzanne"'
Autor:
Levell, Julian, Astles, Peter, Eastwood, Paul, Cairns, Jennifer, Houille, Olivier, Aldous, Suzanne, Merriman, Gregory, Whiteley, Brian, Pribish, James, Czekaj, Mark, Liang, Guyan, Maignan, Sebastien, Guilloteau, Jean-Pierre, Dupuy, Alain, Davidson, Jane, Harrison, Trevor, Morley, Andrew, Watson, Simon, Fenton, Garry, McCarthy, Clive, Romano, Joseph, Mathew, Rose, Engers, Darren, Gardyan, Michael, Sides, Keith, Kwong, Jennifer, Tsay, Joseph, Rebello, Sam, Shen, Liduo, Wang, Jie, Luo, Yongyi, Giardino, Odessa, Lim, Heng-Keang, Smith, Keith, Pauls, Henry
Publikováno v:
In Bioorganic & Medicinal Chemistry 2005 13(8):2859-2872
Autor:
Keith Sides, James Pribish, Magali Mathieu, Sam Rebello, Gregory H. Merriman, Henry W. Pauls, Guyan Liang, Xin Chen, Julian Levell, Jennifer Cairns, Isabelle Morize, Brian Whitely, Joseph T. Tsay, Aldous Suzanne C, Sébastien Maignan
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:1049-1054
A solid phase combinatorial library was designed based on X-ray structures and in-silico models to explore an inducible S4+ pocket, which is formed by a simple side-chain rotation of Tyr95. This inducible S4+ pocket is unique to β-tryptase and does
Autor:
Michael Gardyan, Mathew Rose M, Jane Davidson, Joseph Romano, Alain Dupuy, Aldous Suzanne C, Jennifer Kwong, Sam S. Rebello, Jennifer Cairns, Odessa Giardino, Yongyi Luo, Sébastien Maignan, Andrew David Morley, Clive Mccarthy, Joseph T. Tsay, Darren Engers, Guyan Liang, Houille Olivier, Julian Levell, Pribish James R, Jean-Pierre Guilloteau, Garry Fenton, Simon Watson, Trevor K.P. Harrison, Peter C. Astles, Liduo Shen, Mark Czekaj, Gregory H. Merriman, Keith Sides, Pauls Henry W, Keith Smith, Jie Wang, Heng-Keang Lim, Paul R. Eastwood, Brian Whiteley
Publikováno v:
Bioorganic & Medicinal Chemistry. 13:2859-2872
Tryptase is a serine protease found almost exclusively in mast cells. It has trypsin-like specificity, favoring cleavage of substrates with an arginine (or lysine) at the P1 position, and has optimal catalytic activity at neutral pH. Current evidence
Autor:
Liang, Guyan, Chen, Xin, Aldous, Suzanne, Pu, Su-Fen, Mehdi, Shujaath, Powers, Elaine, Xia, Tianhui, Wang, Rachel
Publikováno v:
In Bioorganic & Medicinal Chemistry Letters 1 April 2012 22(7):2450-2455
Autor:
Liang, Guyan, Aldous, Suzanne, Merriman, Gregory, Levell, Julian, Pribish, James, Cairns, Jennifer, Chen, Xin, Maignan, Sebastien, Mathieu, Magali, Tsay, Joseph, Sides, Keith, Rebello, Sam, Whitely, Brian, Morize, Isabelle, Pauls, Henry W.
Publikováno v:
In Bioorganic & Medicinal Chemistry Letters 15 January 2012 22(2):1049-1054
Autor:
Ying Zhang, Tianhui Xia, Larry R. McLean, Gregory H. Merriman, Aldous Suzanne C, Su-Fen Pu, Guyan Liang, Rachel Wang, Sathapana Kongsamut, Isabelle Morize, Shujaath Mehdi, Xin Chen, Zhongli Gao, Andrew Giovanni, Elaine Powers
Publikováno v:
ACS medicinal chemistry letters. 3(2)
A series of compounds with an amidinothiophene P1 group and a pyrrolidinone-sulphonamide scaffold linker was identified as potent inhibitors of human kallikrein 6 by structure-based virtual screening based on the union accessible binding space of ser
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Autor:
Diana, Guy D., Rudewicz, Patrick, Pevear, Daniel C., Nitz, Theodore J., Aldous, Suzanne C., Aldous, David J., Robinson, David T., Draper, Tandy, Dutko, Frank J., Aldi, Christopher, Gendron, Guy, Oglesby, R. Christopher, Volkots, Deborah L., Reuman, Michael, Bailey, Thomas R., Czerniak, Richard, Block, Tracey, Roland, Robert, Oppermann, James
Publikováno v:
Journal of Medicinal Chemistry; April 1995, Vol. 38 Issue: 8 p1355-1371, 17p
Publikováno v:
Journal of the Chemical Society, Perkin Transactions 1 (0300922X); Jan1990, Issue 1, p171-172, 2p
Autor:
Wentland, Mark P., Aldous, Suzanne C., Gruett, Monte D., Perni, Robert B., Powles, Ronald G., Danz, Deborah W., Klingbeil, Kristina M., Peverly, A.Danielle, Robinson, Ronald G., Corbett, Thomas H., Rake, James B., Coughlin, Susan A.
Publikováno v:
In Bioorganic & Medicinal Chemistry Letters 1995 5(4):405-410