Zobrazeno 1 - 10
of 779
pro vyhledávání: '"Aldose reductase inhibitors"'
Autor:
Babak Sokouti, Maryam Hamzeh-Mivehroud
Publikováno v:
BMC Chemistry, Vol 17, Iss 1, Pp 1-9 (2023)
Abstract The application of QSAR analysis dates back a half-century ago and is currently continuously employed in any rational drug design. The multi-dimensional QSAR modeling can be a promising tool for researchers to develop reliable predictive QSA
Externí odkaz:
https://doaj.org/article/d766d3a6e3004382ba5614949f8f55eb
Akademický článek
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Autor:
Mohsinul Mulk Bacha, Humaira Nadeem, Sumera Zaib, Sadia Sarwar, Aqeel Imran, Shafiq Ur Rahman, Hafiz Saqib Ali, Muazzam Arif, Jamshed Iqbal
Publikováno v:
BMC Chemistry, Vol 15, Iss 1, Pp 1-15 (2021)
Abstract In diabetes, increased accumulation of sorbitol has been associated with diabetic complications through polyol pathway. Aldose reductase (AR) is one of the key factors involved in reduction of glucose to sorbitol, thereby its inhibition is i
Externí odkaz:
https://doaj.org/article/4fa7feffe1c9431f8c8032e1bcd01492
Publikováno v:
Indian Journal of Health Sciences and Biomedical Research KLEU, Vol 14, Iss 2, Pp 194-199 (2021)
Prolonged exposure to hyperglycemia can lead to the development of complications such as cataracts, retinopathy, neuropathy, and nephropathy. Several mechanisms are supposed to be involved in this process such as increased aldose reductase (AR)-relat
Externí odkaz:
https://doaj.org/article/beaf384473024568ba84a4d0d0e3e03c
Autor:
Felicia D'Andrea, Stefania Sartini, Ilaria Piano, Matteo Franceschi, Luca Quattrini, Lorenzo Guazzelli, Lidia Ciccone, Elisabetta Orlandini, Claudia Gargini, Concettina La Motta, Susanna Nencetti
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 1194-1205 (2020)
Aldose reductase is a key enzyme in the development of long term diabetic complications and its inhibition represents a viable therapeutic solution for people affected by these pathologies. Therefore, the search for effective aldose reductase inhibit
Externí odkaz:
https://doaj.org/article/2b923e0da4124b2f977b2ce22fca760a
Akademický článek
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Autor:
Angeline Julius, Waheeta Hopper
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 109, Iss , Pp 708-715 (2019)
Hyperglycemia invoke number of pathways resulting in development of diabetic retinopathy (DR), including protein kinase C activation, increased expression of VEGF, advanced glycation end product (AGEs) formation and activation of polyol pathway, amon
Externí odkaz:
https://doaj.org/article/3ffd3f2abff14e05b81727d810500a97
Publikováno v:
Biomolecules, Vol 12, Iss 4, p 485 (2022)
Aldose reductase, classified within the aldo-keto reductase family as AKR1B1, is an NADPH dependent enzyme that catalyzes the reduction of hydrophilic as well as hydrophobic aldehydes. AKR1B1 is the first enzyme of the so-called polyol pathway that a
Externí odkaz:
https://doaj.org/article/e46625c92b0a42fd887bf376f4cf06d9
Autor:
Lidia Ciccone, Giovanni Petrarolo, Francesca Barsuglia, Carole Fruchart-Gaillard, Evelyne Cassar Lajeunesse, Adeniyi T. Adewumi, Mahmoud E. S. Soliman, Concettina La Motta, Elisabetta Orlandini, Susanna Nencetti
Publikováno v:
Biomolecules, Vol 12, Iss 3, p 448 (2022)
Aldose reductase (ALR2) is the enzyme in charge of developing cellular toxicity caused by diabetic hyperglycemia, which in turn leads to the generation of reactive oxygen species triggering oxidative stress. Therefore, inhibiting ALR2 while pursuing
Externí odkaz:
https://doaj.org/article/851554655f0f4db2a4076f3c911da32b
Akademický článek
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