Výsledky vyhledávání - "Aldose reductase (ALR2) inhibitor"

Spirohydantoin derivatives of thiopyrano[2,3-b]pyridin-4(4H)-one as potent in vitro and in vivo aldose reductase inhibitors

Autor: Federico Da Settimo, Concettina La Motta, Ettore Novellino, Giovanni Greco, Silvia Salerno, Sonia Laneri, Antonio Lavecchia, Giampaolo Primofiore, E. Boldrini

Publikováno v: Bioorganic & Medicinal Chemistry. 13:491-499

The 2,3-dihydrospiro[4H-thiopyrano[2,3-b]pyridin-4,4'-imidazolidine]-2',5'-dione 3 and its 7-methyl analogue 4 were synthesized and tested for their ability to inhibit aldose reductase (ALR2). To expand the structure-activity relationships, the sulfo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f73dfa3fb1495b633011829f5b6aed2a
https://doi.org/10.1016/j.bmc.2004.10.019

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Pyrido[1,2-a]pyrimidin-4-one derivatives as a novel class of selective aldose reductase inhibitors exhibiting antioxidant activity

Autor: C. LA MOTTA, S. SARTINI, L. MUGNAINI, F. SIMORINI, S. TALIANI, S. SALERNO, A. M. MARINI, G. PRIMOFIORE, F. DA SETTIMO, LAVECCHIA, ANTONIO, NOVELLINO, ETTORE, M. CANTORE, P. FAILLI, M. CIUFFI

2-Phenyl-pyrido[1,2-a]pyrimidin-4-one derivatives bearing a phenol or a catechol moiety in position 2 were tested as aldose reductase (ALR2) inhibitors and exhibited activity levels in the micromolar/submicromolar range. Introduction of a hydroxy gro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27da2ed585ca7a72f59c15482e9a7fd3
http://hdl.handle.net/11588/303940

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