A small peptide modeled after the NRAGE repeat domain inhibits XIAP-TAB1-TAK1 signaling for NF-κB activation and apoptosis in P19 cells.

Autor: Jennifer A Rochira, Nicholas N Matluk, Tamara L Adams, Aldona A Karaczyn, Leif Oxburgh, Samuel T Hess, Joseph M Verdi

Publikováno v: PLoS ONE, Vol 6, Iss 7, p e20659 (2011)

In normal growth and development, apoptosis is necessary to shape the central nervous system and to eliminate excess neurons which are not required for innervation. In some diseases, however, apoptosis can be either overactive as in some neurodegener

Externí odkaz: https://doaj.org/article/e75b801b00aa4b13829319f0bcb43348

The octapeptidic end of the C-terminal tail of histone H2A is cleaved off in cells exposed to carcinogenic nickel(II)

Autor: Wojciech Bal, Robert M. Bare, Kazimierz S. Kasprzak, Van M. Hoang, Susan L. North, Aldona A. Karaczyn, Robert J. Fisher

Publikováno v: Chemical research in toxicology. 16(12)

We have demonstrated previously that Ni(II) binds to the C-terminal -TESHHKAKGK motif of isolated bovine histone H2A. At physiological pH, the bound Ni(II) assists in hydrolysis of the E-S peptide bond in this motif that results in a cleavage of the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f6107cb14efd020c9a523e3537ab8d0
https://pubmed.ncbi.nlm.nih.gov/14680369

Thyroid hormone influences brain gene expression programs and behaviors in later generations by altering germ line epigenetic information.

Autor: Martinez ME; Center for Molecular Medicine, Maine Medical Center Research Institute, Maine Medical Center, Scarborough, ME, 04074, USA., Duarte CW; Center for Outcomes Research and Evaluation, Maine Medical Center Research Institute, Maine Medical Center, Scarborough, ME, 04074, USA.; Graduate School for Biomedical Science and Engineering, University of Maine, Orono, ME, 04469, USA., Stohn JP; Center for Molecular Medicine, Maine Medical Center Research Institute, Maine Medical Center, Scarborough, ME, 04074, USA., Karaczyn A; Center for Molecular Medicine, Maine Medical Center Research Institute, Maine Medical Center, Scarborough, ME, 04074, USA., Wu Z; Center for Molecular Medicine, Maine Medical Center Research Institute, Maine Medical Center, Scarborough, ME, 04074, USA., DeMambro VE; Center for Molecular Medicine, Maine Medical Center Research Institute, Maine Medical Center, Scarborough, ME, 04074, USA., Hernandez A; Center for Molecular Medicine, Maine Medical Center Research Institute, Maine Medical Center, Scarborough, ME, 04074, USA. hernaa@mmc.org.; Graduate School for Biomedical Science and Engineering, University of Maine, Orono, ME, 04469, USA. hernaa@mmc.org.; Department of Medicine, Tufts University School of Medicine, Boston, MA, USA. hernaa@mmc.org.

Publikováno v: Molecular psychiatry [Mol Psychiatry] 2020 May; Vol. 25 (5), pp. 939-950. Date of Electronic Publication: 2018 Oct 24.

The Type 3 Deiodinase Is a Critical Determinant of Appropriate Thyroid Hormone Action in the Developing Testis.

Autor: Martinez ME; Department of Molecular Medicine (M.E.M., A.K., J.P.S., D.S.G., A.H.), Maine Medical Center Research Institute, Scarborough, Maine 04074; Departments of Physiology and Neurobiology (W.D., V.A.G.) and Medicine (W.C.), Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire 03756; Rotterdam Thyroid Center (R.P.P.), Department of Internal Medicine, Erasmus MC, 3000 CA Rotterdam, The Netherlands; and Laboratory of Endocrinology and Receptor Biology (R.P.P., D.F.), National Institute of Diabetes, Digestive and Kidney Diseases, Bethesda, Maryland 20892., Karaczyn A; Department of Molecular Medicine (M.E.M., A.K., J.P.S., D.S.G., A.H.), Maine Medical Center Research Institute, Scarborough, Maine 04074; Departments of Physiology and Neurobiology (W.D., V.A.G.) and Medicine (W.C.), Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire 03756; Rotterdam Thyroid Center (R.P.P.), Department of Internal Medicine, Erasmus MC, 3000 CA Rotterdam, The Netherlands; and Laboratory of Endocrinology and Receptor Biology (R.P.P., D.F.), National Institute of Diabetes, Digestive and Kidney Diseases, Bethesda, Maryland 20892., Stohn JP; Department of Molecular Medicine (M.E.M., A.K., J.P.S., D.S.G., A.H.), Maine Medical Center Research Institute, Scarborough, Maine 04074; Departments of Physiology and Neurobiology (W.D., V.A.G.) and Medicine (W.C.), Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire 03756; Rotterdam Thyroid Center (R.P.P.), Department of Internal Medicine, Erasmus MC, 3000 CA Rotterdam, The Netherlands; and Laboratory of Endocrinology and Receptor Biology (R.P.P., D.F.), National Institute of Diabetes, Digestive and Kidney Diseases, Bethesda, Maryland 20892., Donnelly WT; Department of Molecular Medicine (M.E.M., A.K., J.P.S., D.S.G., A.H.), Maine Medical Center Research Institute, Scarborough, Maine 04074; Departments of Physiology and Neurobiology (W.D., V.A.G.) and Medicine (W.C.), Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire 03756; Rotterdam Thyroid Center (R.P.P.), Department of Internal Medicine, Erasmus MC, 3000 CA Rotterdam, The Netherlands; and Laboratory of Endocrinology and Receptor Biology (R.P.P., D.F.), National Institute of Diabetes, Digestive and Kidney Diseases, Bethesda, Maryland 20892., Croteau W; Department of Molecular Medicine (M.E.M., A.K., J.P.S., D.S.G., A.H.), Maine Medical Center Research Institute, Scarborough, Maine 04074; Departments of Physiology and Neurobiology (W.D., V.A.G.) and Medicine (W.C.), Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire 03756; Rotterdam Thyroid Center (R.P.P.), Department of Internal Medicine, Erasmus MC, 3000 CA Rotterdam, The Netherlands; and Laboratory of Endocrinology and Receptor Biology (R.P.P., D.F.), National Institute of Diabetes, Digestive and Kidney Diseases, Bethesda, Maryland 20892., Peeters RP; Department of Molecular Medicine (M.E.M., A.K., J.P.S., D.S.G., A.H.), Maine Medical Center Research Institute, Scarborough, Maine 04074; Departments of Physiology and Neurobiology (W.D., V.A.G.) and Medicine (W.C.), Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire 03756; Rotterdam Thyroid Center (R.P.P.), Department of Internal Medicine, Erasmus MC, 3000 CA Rotterdam, The Netherlands; and Laboratory of Endocrinology and Receptor Biology (R.P.P., D.F.), National Institute of Diabetes, Digestive and Kidney Diseases, Bethesda, Maryland 20892., Galton VA; Department of Molecular Medicine (M.E.M., A.K., J.P.S., D.S.G., A.H.), Maine Medical Center Research Institute, Scarborough, Maine 04074; Departments of Physiology and Neurobiology (W.D., V.A.G.) and Medicine (W.C.), Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire 03756; Rotterdam Thyroid Center (R.P.P.), Department of Internal Medicine, Erasmus MC, 3000 CA Rotterdam, The Netherlands; and Laboratory of Endocrinology and Receptor Biology (R.P.P., D.F.), National Institute of Diabetes, Digestive and Kidney Diseases, Bethesda, Maryland 20892., Forrest D; Department of Molecular Medicine (M.E.M., A.K., J.P.S., D.S.G., A.H.), Maine Medical Center Research Institute, Scarborough, Maine 04074; Departments of Physiology and Neurobiology (W.D., V.A.G.) and Medicine (W.C.), Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire 03756; Rotterdam Thyroid Center (R.P.P.), Department of Internal Medicine, Erasmus MC, 3000 CA Rotterdam, The Netherlands; and Laboratory of Endocrinology and Receptor Biology (R.P.P., D.F.), National Institute of Diabetes, Digestive and Kidney Diseases, Bethesda, Maryland 20892., St Germain D; Department of Molecular Medicine (M.E.M., A.K., J.P.S., D.S.G., A.H.), Maine Medical Center Research Institute, Scarborough, Maine 04074; Departments of Physiology and Neurobiology (W.D., V.A.G.) and Medicine (W.C.), Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire 03756; Rotterdam Thyroid Center (R.P.P.), Department of Internal Medicine, Erasmus MC, 3000 CA Rotterdam, The Netherlands; and Laboratory of Endocrinology and Receptor Biology (R.P.P., D.F.), National Institute of Diabetes, Digestive and Kidney Diseases, Bethesda, Maryland 20892., Hernandez A; Department of Molecular Medicine (M.E.M., A.K., J.P.S., D.S.G., A.H.), Maine Medical Center Research Institute, Scarborough, Maine 04074; Departments of Physiology and Neurobiology (W.D., V.A.G.) and Medicine (W.C.), Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire 03756; Rotterdam Thyroid Center (R.P.P.), Department of Internal Medicine, Erasmus MC, 3000 CA Rotterdam, The Netherlands; and Laboratory of Endocrinology and Receptor Biology (R.P.P., D.F.), National Institute of Diabetes, Digestive and Kidney Diseases, Bethesda, Maryland 20892.

Publikováno v: Endocrinology [Endocrinology] 2016 Mar; Vol. 157 (3), pp. 1276-88. Date of Electronic Publication: 2016 Jan 04.

A role for NRAGE in NF-kappaB activation through the non-canonical BMP pathway.

Autor: Matluk N; Center for Molecular Medicine, Maine Medical Center Research Institute, 81 Research Drive, Scarborough, ME 04074, USA., Rochira JA, Karaczyn A, Adams T, Verdi JM

Publikováno v: BMC biology [BMC Biol] 2010 Jan 25; Vol. 8, pp. 7. Date of Electronic Publication: 2010 Jan 25.