Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Aldo Ciau-Uitz"'
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
How vegfa expression is transcriptionally regulated in vivo is unclear. Here, the authors demonstrate that the ETS transcription factor Etv6 acts as a repressor and an activator of two direct regulators of vegfa expression (foxo3 and klf4, respective
Externí odkaz:
https://doaj.org/article/ab8a78cea7274decb08b67fe512c423d
Publikováno v:
PLoS Computational Biology, Vol 14, Iss 8, p e1006077 (2018)
The precise anatomical location of gene expression is an essential component of the study of gene function. For most model organisms this task is usually undertaken via visual inspection of gene expression images by interested researchers. Computatio
Externí odkaz:
https://doaj.org/article/51987c80ce4d4b14b5ba87f841520f4a
Publikováno v:
Proceedings of the National Academy of Sciences. 114:5814-5821
Hematopoietic stem cells (HSCs) that sustain lifelong blood production are created during embryogenesis. They emerge from a specialized endothelial population, termed hemogenic endothelium (HE), located in the ventral wall of the dorsal aorta (DA). I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b13bc2a503e0d7f58e085bef2fafb4ac
https://doi.org/10.1073/pnas.1610615114
https://doi.org/10.1073/pnas.1610615114
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Nature Communications
Nature Communications
VEGFA signaling controls physiological and pathological angiogenesis and hematopoiesis. Although many context-dependent signaling pathways downstream of VEGFA have been uncovered, vegfa transcriptional regulation in vivo remains unclear. Here, we sho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d17a2d6b931e9c9da07d79e2bb09778d
http://ora.ox.ac.uk/objects/uuid:
http://ora.ox.ac.uk/objects/uuid:
Autor:
Roger Patient, Aldo Ciau-Uitz
Publikováno v:
Europe PubMed Central
Haematopoietic stem cells (HSCs) emerge from the haemogenic endothelium (HE) localised in the ventral wall of the embryonic dorsal aorta (DA). The HE generates HSCs through a process known as the endothelial to haematopoietic transition (EHT), which
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9845738cc3e2a6d08531c07f5ebefb7
https://doi.org/10.1002/1873-3468.12363
https://doi.org/10.1002/1873-3468.12363
VEGFA signaling is crucial for physiological and pathological angiogenesis and hematopoiesis. Although many context-dependent signaling pathways downstream of VEGFA have been uncovered, vegfa transcriptional regulation in vivo remains unclear. Here w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62a560d62ea0ac8b733fcef0a6896760
SUMMARYHematopoietic stem cells (HSCs) emerge from hemogenic endothelium (HE) localised in the embryonic dorsal aorta (DA). Here we show that Runx1, a transcription factor essential for HSC emergence, controls HE establishment in the absence of its n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17712fe302dec398b1d363b04a236ad1
Autor:
Catherine Porcher, Rui Monteiro, Aldo Ciau-Uitz, Amy Leung, Philip Pinheiro, Paresh Vyas, Roger Patient, Jie Zuo
Publikováno v:
Developmental Cell
Summary VEGFA signaling is critical for endothelial and hematopoietic stem cell (HSC) specification. However, blood defects resulting from perturbation of the VEGFA pathway are always accompanied by impaired vascular/arterial development. Because HSC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d70a92a6066a35c13ba8eb321b51e67
https://ora.ox.ac.uk/objects/uuid:cb87322e-88a3-4b75-9bae-8de3a9c93d34
https://ora.ox.ac.uk/objects/uuid:cb87322e-88a3-4b75-9bae-8de3a9c93d34