Improved hepatic MRP2/ABCC2 transport activity in LPS-induced cholestasis by aquaporin-1 gene transfer

Autor: Raúl A. Marinelli, Aldo D. Mottino, Guillermo Nicolás Tocchetti, Julieta Marrone, Mauro Danielli

Publikováno v: Biochimie. 165:179-182

Multidrug resistance-associated protein 2 (MRP2/ABCC2), a hepatocyte canalicular transporter involved in bile secretion, is downregulated in cholestasis triggered by lipopolysaccharide. The human aquaporin-1 (hAQP1) adenovirus-mediated gene transfer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::729032b0b7c61b62a818d786cec92ab3
https://doi.org/10.1016/j.biochi.2019.07.027

Multidrug resistance-associated protein 2 is negatively regulated by oxidative stress in rat intestine via a posttranslational mechanism. Impact on its membrane barrier function

Autor: Camila Juliana Domínguez, María Manuela Barranco, Virginia Gabriela Perdomo, Felipe Zecchinati, Maite Rocío Arana, Guillermo Nicolás Tocchetti, Aldo D. Mottino, Silvina Stella Maris Villanueva, Fabiana García

Publikováno v: Toxicology. 460

Oxidative stress (OS) is a key factor in the development of gastrointestinal disorders, in which the intestinal barrier is altered. However, the Multidrug resistance-associated protein 2 (Mrp2) status, an essential component of the intestinal transce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64044460213989c2d351007f128cdb29
https://pubmed.ncbi.nlm.nih.gov/34303734

Acute regulation of apical ABC transporters in the gut. Potential influence on drug bioavailability

Autor: Aldo D. Mottino, Guillermo Nicolás Tocchetti, Juan Pablo Rigalli, Camila Juliana Domínguez

Publikováno v: Pharmacological Research, 163

The extensive intestinal surface offers an advantage regarding nutrient, ion and water absorptive capacity but also brings along a high exposition to xenobiotics, including drugs of therapeutic use and food contaminants. After absorption of these com

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bc8ab0bc19249aca69851dc49760b8d
https://hdl.handle.net/2066/230709

Intraluminal nutrients acutely strengthen rat intestinal MRP2 barrier function by a glucagon-like peptide-2-mediated mechanism

Autor: Guillermo Nicolás Tocchetti, Felipe Zecchinati, María L. Ruiz, Silvina Stella Maris Villanueva, Aldo D. Mottino, Juan Pablo Rigalli, Maite Rocío Arana, Camila Juliana Domínguez

Publikováno v: Acta Physiologica, 230
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Acta Physiologica, 230, 4

Aim: MRP2 is an intestinal ABC transporter that prevents the absorption of dietary xenobiotics. The aims of this work were: (1) to evaluate whether a short-term regulation of intestinal MRP2 barrier function takes place in vivo after luminal incorpor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d17ee758f4ece2e04c210a24f9c1c505
http://hdl.handle.net/2066/229885

Regulation of biotransformation systems and ABC transporters by benznidazole in HepG2 cells: involvement of pregnane X-receptor.

Autor: Juan P Rigalli, Virginia G Perdomo, Marcelo G Luquita, Silvina S M Villanueva, Agostina Arias, Dirk Theile, Johanna Weiss, Aldo D Mottino, María L Ruiz, Viviana A Catania

Publikováno v: PLoS Neglected Tropical Diseases, Vol 6, Iss 12, p e1951 (2012)

BACKGROUND: Benznidazole (BZL) is the only antichagasic drug available in most endemic countries. Its effect on the expression and activity of drug-metabolizing and transporter proteins has not been studied yet. METHODOLOGY/PRINCIPAL FINDINGS: Expres

Externí odkaz: https://doaj.org/article/7653d70c06d3481fb0be018f385014c5