Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Aldo, Profumo"'
Autor:
Iméne Ben Toumia, Tiziana Bachetti, Leila Chekir-Ghedira, Aldo Profumo, Marco Ponassi, Alessandro Di Domizio, Alberto Izzotti, Salvatore Sciacca, Caterina Puglisi, Stefano Forte, Raffaella Giuffrida, Cristina Colarossi, Danilo Milardi, Giuseppe Grasso, Valeria Lanza, Stefano Fiordoro, Giacomo Drago, Kateryna Tkachenko, Barbara Cardinali, Paolo Romano, Erika Iervasi, Gabriela Coronel Vargas, Paola Barboro, Franz Heinrich Kohnke, Camillo Rosano
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2024)
Background and purpose: Lung cancer is the leading cause of death in both men and women, constituting a major public health problem worldwide. Non-small-cell lung cancer accounts for 85%–90% of all lung cancers. We propose a compound that successfu
Externí odkaz:
https://doaj.org/article/dc6ffba98dfa4c89a608a26bff651fbc
Autor:
Katia Cortese, Marco Ponassi, Aldo Profumo, Gabriela Coronel Vargas, Erika Iervasi, Maria Cristina Gagliani, Grazia Bellese, Sara Tavella, Patrizio Castagnola
Publikováno v:
Membranes, Vol 13, Iss 6, p 540 (2023)
Trastuzumab (Tz), an antibody targeting ERBB2, has significantly improved the prognosis for breast cancer (BCa) patients with overexpression of the ERBB2 receptor. However, Tz resistance poses a challenge to patient outcomes. Numerous mechanisms have
Externí odkaz:
https://doaj.org/article/a7b59a7cfc134f189947cb13cc46c452
Autor:
Matteo Lusardi, Aldo Profumo, Chiara Rotolo, Erika Iervasi, Camillo Rosano, Andrea Spallarossa, Marco Ponassi
Publikováno v:
Molecules, Vol 27, Iss 18, p 5814 (2022)
A small library of highly functionalized phenylaminopyrazoles, bearing different substituents at position 1, 3, and 4 of the pyrazole ring, was prepared by the one-pot condensation of active methylene reagents, phenylisothiocyanate, and substituted h
Externí odkaz:
https://doaj.org/article/893a1deffe5d4b26a131af443dbc5b6f
Publikováno v:
Frontiers in Genetics, Vol 12 (2021)
Mass spectrometry is a widely applied technology with a strong impact in the proteomics field. MALDI-TOF is a combined technology in mass spectrometry with many applications in characterizing biological samples from different sources, such as the ide
Externí odkaz:
https://doaj.org/article/20b4d08175214a89aeab8a0e4201f67f
Autor:
Guido Fròsina, Aldo Profumo, Daniela Marubbi, Diana Marcello, Jean Louis Ravetti, Antonio Daga
Publikováno v:
Radiation Oncology, Vol 13, Iss 1, Pp 1-7 (2018)
Abstract Ataxia Telangiectasia and Rad3 related protein (ATR) is a central mediator of the response to DNA damage that may cause the quiescent resistance of cancer initiating cells to genotoxic radiotherapy. NVP-BEZ235 is a dual PI3K/mTOR inhibitor t
Externí odkaz:
https://doaj.org/article/862665ae4267477d856ba62ef2c4ec18
Publikováno v:
Applied Sciences, Vol 11, Iss 4, p 1931 (2021)
The aim of this research was to evaluate the effects of different lens types on the availability and efficacy of anti-inflammatory and antibiotic drugs. Three lens types were examined: (1) nonionic hydrogel lenses; (2) ionic hydrogel lenses; and (3)
Externí odkaz:
https://doaj.org/article/84ccd1ad35e14e4f8c939a10399ea9a1
Autor:
Andrea Spallarossa, Matteo Lusardi, Chiara Caneva, Aldo Profumo, Camillo Rosano, Marco Ponassi
Publikováno v:
Molecules, Vol 26, Iss 3, p 557 (2021)
Pyrimido-pyrimidine derivatives have been developed as rigid merbarone analogues. In a previous study, these compounds showed potent antiproliferative activity and efficiently inhibited topoisomerase IIα. To further extend the structure–activity r
Externí odkaz:
https://doaj.org/article/7289d19e623f46bb9e6c0b4579899df0
Publikováno v:
Applied Sciences, Vol 10, Iss 24, p 9055 (2020)
Aloe vera extracts have been used for drug therapy due to their antimicrobial, anti-inflammatory, and epithelia-regenerative actions. Considering the possible adverse side effects on the corneal surface of anti-microbial agent administration after oc
Externí odkaz:
https://doaj.org/article/831309ad287542b1b48c6675a92a50f7
Autor:
Maider Beitia, Paolo Romano, Gorka Larrinaga, Jon Danel Solano-Iturri, Annalisa Salis, Gianluca Damonte, Marco Bruzzone, Marcello Ceppi, Aldo Profumo
Publikováno v:
Diagnostics, Vol 10, Iss 12, p 1077 (2020)
Colorectal cancer (CRC) is the second cause of death in men and the third in women. This work deals with the study of the low molecular weight protein fraction of sera from patients who underwent surgery for CRC and who were followed for several year
Externí odkaz:
https://doaj.org/article/62456d9c751f458b9fc9a59915ea3072
Autor:
Giambattista Bonanno, Nadia Bertola, Giulia Frumento, Mandeep Kumar, T P Nhung Nguyen, Tiziana Bonifacino, Arianna Roberta Zerbo, Carola Torazza, Matilde Balbi, Maurizio Viale, Aldo Profumo, Sara Ferrando, Francesca Provenzano, Marco Milanese, Silvia Ravera
Publikováno v:
British Journal of Pharmacology
British journal of pharmacology 178(18), 3747-3764 (2021). doi:10.1111/bph.15515
British journal of pharmacology 178(18), 3747-3764 (2021). doi:10.1111/bph.15515
Background and Purpose The pathogenesis of amyotrophic lateral sclerosis (ALS) is not fully clarified, although excessive glutamate (Glu) transmission and the downstream cytotoxic cascades are major mechanisms for motor neuron death. Two metabotropic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::805959c366c7fb322120e653e595c2b8
https://doi.org/10.1111/bph.15515
https://doi.org/10.1111/bph.15515