Výsledky vyhledávání - "Aldo, Balsamo"

Predictive models, based on classification algorithms, for compounds potentially active as mitochondrial ATP-sensitive potassium channel openers

Autor: Lara Testai, Vincenzo Calderone, Maria Digiacomo, Anna Maria Paola Bianucci, Aldo Balsamo, Alessio Coi, Simona Rapposelli

Publikováno v: Bioorganic & Medicinal Chemistry. 17:5565-5571

Heart mitochondrial ATP-sensitive potassium channel (mito-K ATP channels) are deeply implicated in the self-defense mechanism of ischemic preconditioning. Therefore, exogenous molecules activating these channels are considered as a promising pharmaco

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dddfddd0999445e00049a7559872a29
https://doi.org/10.1016/j.bmc.2009.06.028

Zobrazit plný text záznamu

Evaluation of the NO-releasing properties of NO-donor linkers

Autor: Filippo Minutolo, Aldo Balsamo, Alma Martelli, Lara Testai, Vincenzo Calderone, Simona Rapposelli, Maria Digiacomo

Publikováno v: Journal of Pharmacy and Pharmacology. 60:189-195

This work describes the synthesis of some benzoic (1–4) and alcoholic (5–7) nitrooxy derivatives, which are nitric oxide (NO) donors in themselves, and can also be seen as useful linkers that can be used in multi-target drugs capable of releasing

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af7da4a2cf74d337b3096ec96074a7cf
https://doi.org/10.1211/jpp.60.2.0007

Zobrazit plný text záznamu

Synthesis and 5-HT2A, 5-HT1Aand α1-Binding Affinities of 2-[2-Hydroxy-3-(pyridin-3-yl-methyl)amino]-, 2-[2-Hydroxy-3-(2-pyridin-2-yl-ethyl)amino]- and 2-[2-Hydroxy-3-(4-N-methyl-piperazin-1-yl)-amino]propoxybenzaldehyde-O-(substituted) Benzyl Oximes

Autor: Susanna Nencetti, Elisabetta Orlandini, Simona Rapposelli, Gino Giannaccini, Aldo Balsamo, Laura Betti

Publikováno v: Archiv der Pharmazie. 340:135-139

Some oxime ether-substituted aryloxypropanolamines 3-5, structurally related to the active metabolite 2 of sarpogrelate 1, were synthesized and tested for their affinities at 5-HT2A and 5-HT1A serotoninergic receptors as well as at the alpha1-adrenoc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9eded0e8bced2d88f12b1ad615671e03
https://doi.org/10.1002/ardp.200600123

Zobrazit plný text záznamu

New NO-Releasing Pharmacodynamic Hybrids of Losartan and Its Active Metabolite: Design, Synthesis, and Biopharmacological Properties

Autor: Marco Macchia, Vincenzo Calderone, Maria Cristina Breschi, Filippo Minutolo, Simona Rapposelli, Armando Rossello, Aldo Balsamo, Alma Martelli, Lara Testai, Enrica Martinotti, Maria Digiacomo

Publikováno v: Journal of Medicinal Chemistry. 49:2628-2639

In a preliminary work, we reported two NO-sartans, possessing the characteristics of an AT(1) antagonist and a "slow NO donor", obtained by adding NO-donor side chains to losartan 1. The NO release from an NO-sartan should be modulated in order to st

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb5c45a17d2c62df7c8e247d4ecc4b87
https://doi.org/10.1021/jm0600186

Zobrazit plný text záznamu

(E)-[2-(4-Methylsulphonylphenyl)-1-cyclopentenyl-1-methyliden](arylmethyloxy)amines. Methyleneaminoxymethyl (MAOM) analogues of diarylcyclopentenyl cyclooxygenase-2 inhibitors: synthesis and biological properties

Autor: Mario Pinza, Claudio Milanese, Carla Landolfi, Paolo Domiano, Bruno Macchia, Francesca Mancini, Aldo Balsamo, Isabella Coletta, Simona Rapposelli, Elisabetta Orlandini, Angelo Guglielmotti

Publikováno v: European Journal of Medicinal Chemistry. 37:391-398

The (E)-[2-(4-Methylsulphonylphenyl)-1-cyclopentenyl-1-methyliden](methyloxy)amine (5) and (arylmethyloxy)amines (6–12) were designed in order to verify the effects on the biological properties of the substitution of an aryl of selective diarylcycl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f294a9b8e4bdf54dd35199999314bb06
https://doi.org/10.1016/s0223-5234(02)01359-4

Zobrazit plný text záznamu

Conformationally restrained analogues of sympathomimetic catecholamines

Autor: Annalina Lapucci, Clementina Manera, Gino Giannaccini, Adriano Martinelli, Aldo Balsamo, Vincenzo Calderone, Paola Nieri, Susanna Nencetti, Elisabetta Orlandini

Publikováno v: European Journal of Medicinal Chemistry. 37:11-22

The 5,6- (10a) and 6,7-dihydroxy-3,4-dihydrospiro[naphthalen-1(2H)-2′,5′-morpholine] (11a) and their N-isopropyl derivatives (10b and 11b) (DDSNMs), which can be viewed as the result of the combination of the structure of the 2-(3,4-dihydroxyphen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::863572fa9bc5a1f09af1023740996cff
https://doi.org/10.1016/s0223-5234(01)01322-8

Zobrazit plný text záznamu

Synthesis and β-Adrenergic Properties of (Z)-N-[3-(Alkylamino)-2-hydroxypropylidene](aryl-methyloxy)amines: Effects of the Configuration Around the Methyloxyiminomethyl (MOIM) Double Bond on the Biopharmacological Properties of MOIM-type β-Blocking Agents

Autor: Annalina Lapucci, Eugenio Micali, Adriano Martinelli, N Lazzeri, Armando Rossello, Aldo Balsamo, Grazia Chiellini, Marco Macchia, Maria Cristina Breschi, Susanna Nencetti

Publikováno v: Bioorganic & Medicinal Chemistry. 6:2151-2160

The N -isopropyl- ( 3a–g ) and N - tert -butyl-substituted ( 4a–g ) ( Z )- N -(3-(amino)-2-hydroxypropylidene)(arylmethyloxy)amines were synthesized in order to compare their β 1 - and β 2 -adrenergic properties with those of their previously s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef9b09160e342d45ffb3824f2631df03
https://doi.org/10.1016/s0968-0896(98)00172-2

Zobrazit plný text záznamu

New β-lactam monocyclic inhibitors of human elastases: Synthesis and anti-elastase properties of 1-carbamoyl-4-methyleneaminoxyazetidinone derivatives

Autor: Giovanni Cercignani, Belfiore, M. Mantovanini, Elisabetta Orlandini, Daniela Gentili, Aldo Balsamo, L. Brandolini, C. Asti, Marco Macchia, Armando Rossello

Publikováno v: European Journal of Medicinal Chemistry. 32:889-894

Summary Some monocyclic β-lactam derivatives of types II (1a-5a) and III (1b-5b) , designed as analogs of type I derivatives, in which the C-4 aryloxy group of I is replaced by an oximate moiety, were synthesized and tested in vitro for their inhibi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3b4fd63490203dd46b23d03739f2920
https://doi.org/10.1016/s0223-5234(97)82774-2

Zobrazit plný text záznamu

Sodium N-(methylsulfonyl)-N-(4-nitro-2-phenoxyphenyl)sulfamate: a water-soluble nimesulide prodrug for parenteral use

Autor: Paola Sacerdote, Simona Rapposelli, Aldo Balsamo, Sara Moretti, Mario Pinza, Maria Digiacomo, Silvia Franchi

Publikováno v: Molecular pharmaceutics. 7(5)

Several nimesulide preparations (i.e., tablet form, gels) have been marketed, but no parenteral solution has achieved the market because of their low wettability and unsatisfactory chemical-physical properties required for parenteral use. In this pap

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa9f52163a844bceb7b38c74281b9f52
https://pubmed.ncbi.nlm.nih.gov/23282004

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání