PIK3CA dependence and sensitivity to therapeutic targeting in urothelial carcinoma

Autor: Ross, R.L., McPherson, H.R., Kettlewell, L., Shnyder, Steven, Hurst, C.D., Alder, O., Knowles, M.A.

Yes
Background: Many urothelial carcinomas (UC) contain activating PIK3CA mutations. In telomerase-immortalized normal urothelial cells (TERT-NHUC), ectopic expression of mutant PIK3CA induces PI3K pathway activation, cell proliferation and cell

Externí odkaz: http://hdl.handle.net/10454/8800

Development of resistance to FGFR inhibition in urothelial carcinoma via multiple pathways in vitro.

Autor: Pettitt GA; Division of Molecular Medicine, Leeds Institute of Medical Research at St James's, St James's University Hospital, Leeds, UK., Hurst CD; Division of Molecular Medicine, Leeds Institute of Medical Research at St James's, St James's University Hospital, Leeds, UK., Khan Z; Division of Molecular Medicine, Leeds Institute of Medical Research at St James's, St James's University Hospital, Leeds, UK., McPherson HR; Division of Molecular Medicine, Leeds Institute of Medical Research at St James's, St James's University Hospital, Leeds, UK., Dunning MC; Division of Molecular Medicine, Leeds Institute of Medical Research at St James's, St James's University Hospital, Leeds, UK., Alder O; Division of Molecular Medicine, Leeds Institute of Medical Research at St James's, St James's University Hospital, Leeds, UK., Platt FM; Division of Molecular Medicine, Leeds Institute of Medical Research at St James's, St James's University Hospital, Leeds, UK., Black EV; Division of Molecular Medicine, Leeds Institute of Medical Research at St James's, St James's University Hospital, Leeds, UK., Burns JE; Division of Molecular Medicine, Leeds Institute of Medical Research at St James's, St James's University Hospital, Leeds, UK., Knowles MA; Division of Molecular Medicine, Leeds Institute of Medical Research at St James's, St James's University Hospital, Leeds, UK.

Publikováno v: The Journal of pathology [J Pathol] 2023 Feb; Vol. 259 (2), pp. 220-232. Date of Electronic Publication: 2022 Dec 13.

Stage-stratified molecular profiling of non-muscle-invasive bladder cancer enhances biological, clinical, and therapeutic insight.

Autor: Hurst CD; Division of Molecular Medicine, Leeds Institute of Medical Research at St James's, St James's University Hospital, Beckett Street, Leeds LS9 7TF, UK., Cheng G; Division of Molecular Medicine, Leeds Institute of Medical Research at St James's, St James's University Hospital, Beckett Street, Leeds LS9 7TF, UK., Platt FM; Division of Molecular Medicine, Leeds Institute of Medical Research at St James's, St James's University Hospital, Beckett Street, Leeds LS9 7TF, UK., Castro MAA; Bioinformatics and Systems Biology Laboratory, Federal University of Paraná, Curitiba, Brazil., Marzouka NS; Division of Oncology, Department of Clinical Sciences, Lund University, Lund, Sweden., Eriksson P; Division of Oncology, Department of Clinical Sciences, Lund University, Lund, Sweden., Black EVI; Division of Molecular Medicine, Leeds Institute of Medical Research at St James's, St James's University Hospital, Beckett Street, Leeds LS9 7TF, UK., Alder O; Division of Molecular Medicine, Leeds Institute of Medical Research at St James's, St James's University Hospital, Beckett Street, Leeds LS9 7TF, UK., Lawson ARJ; Cancer, Ageing and Somatic Mutation Programme, Wellcome Sanger Institute, Hinxton CB10 1SA, UK., Lindskrog SV; Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark.; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark., Burns JE; Division of Molecular Medicine, Leeds Institute of Medical Research at St James's, St James's University Hospital, Beckett Street, Leeds LS9 7TF, UK., Jain S; Pyrah Department of Urology, St James's University Hospital, Beckett Street, Leeds LS9 7TF, UK., Roulson JA; Department of Histopathology, St James's University Hospital, Beckett Street, Leeds LS9 7TF, UK., Brown JC; Division of Molecular Medicine, Leeds Institute of Medical Research at St James's, St James's University Hospital, Beckett Street, Leeds LS9 7TF, UK., Koster J; Laboratory for Experimental Oncology and Radiobiology, Center for Experimental and Molecular Medicine, Amsterdam University Medical Centers, University of Amsterdam, Cancer Center Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, the Netherlands., Robertson AG; Canada's Michael Smith Genome Sciences Center, BC Cancer, Vancouver, BC V5Z 4S6, Canada., Martincorena I; Cancer, Ageing and Somatic Mutation Programme, Wellcome Sanger Institute, Hinxton CB10 1SA, UK., Dyrskjøt L; Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark.; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark., Höglund M; Division of Oncology, Department of Clinical Sciences, Lund University, Lund, Sweden., Knowles MA; Division of Molecular Medicine, Leeds Institute of Medical Research at St James's, St James's University Hospital, Beckett Street, Leeds LS9 7TF, UK.

Publikováno v: Cell reports. Medicine [Cell Rep Med] 2021 Dec 21; Vol. 2 (12), pp. 100472. Date of Electronic Publication: 2021 Dec 21 (Print Publication: 2021).

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Bladder Cancer Molecular Classification: Current Status and Future Prospects.

Autor: Khalifa, Eman H.¹ imanali72@hotmail.com

Publikováno v: Zagazig University Medical Journal. Aug2024, Vol. 30 Issue 5, p1815-1824. 10p.