Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Aldemar Degroot"'
Autor:
Aldemar Degroot
The attrition rate in central nervous system (CNS) drug development has been particularly high, and this is in part due to a poor preclinical to clinical translation, a lack of surrogate biomarkers, and a difficult-to-treat patient population. Howeve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::583eb2552d2ebaab8dabfaba3da3adf6
https://doi.org/10.1016/b978-0-12-803161-2.00002-3
https://doi.org/10.1016/b978-0-12-803161-2.00002-3
Autor:
Olivia M, Balcer, Matthew A, Seager, Scott D, Gleason, Xia, Li, Kurt, Rasmussen, Julia K, Maxwell, George, Nomikos, Aldemar, Degroot, Jeffrey M, Witkin
Publikováno v:
Behavioural brain research. 360
The 5-HT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::01037a078823815a8d96b4465a08d1b1
https://pubmed.ncbi.nlm.nih.gov/30543903
https://pubmed.ncbi.nlm.nih.gov/30543903
Publikováno v:
European Journal of Pharmacology. 551:162-167
Although the involvement of cannabinoids and the endogenous cannabinoid system in the regulation of the hypothalamo-pituitary-adrenal axis in rodents is well documented, the precise role played by the cannabinoid type one (CB(1)) receptor in this eff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e80d47ddaa390f9c3742c664e780a38b
https://doi.org/10.1016/j.ejphar.2006.08.083
https://doi.org/10.1016/j.ejphar.2006.08.083
Autor:
Nelson Rebola, Richard J. Davis, Attila Köfalvi, Mark R. Wade, George G. Nomikos, Rodrigo A. Cunha, Aldemar Degroot, Ricardo Gouveia Rodrigues
Publikováno v:
Molecular Pharmacology. 70:1236-1245
Evidence indicates that blockade of cannabinoid receptors increases acetylcholine (ACh) release in brain cortical regions. Although it is assumed that this type of effect is mediated through CB1 receptor (CB1R) antagonism, several in vitro functional
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8ade97621948c17418a145ee27cffc0
https://doi.org/10.1124/mol.106.024661
https://doi.org/10.1124/mol.106.024661
Autor:
George G. Nomikos, Aldemar Degroot
Publikováno v:
European Journal of Pharmacology. 531:183-186
We used muscarinic M2 and M4 receptor knockout (KO) mice to further explore the role of the cholinergic system in anxiety. Using the shock-probe burying model we were able to both assess anxiety and cognition. In this paradigm, an anxiolytic response
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06a9315cdb92e111a5460e1e5632cbea
https://doi.org/10.1016/j.ejphar.2005.12.036
https://doi.org/10.1016/j.ejphar.2005.12.036
Publikováno v:
Behavioural Brain Research. 162:161-164
Habituation (a form of non-associative learning) was measured by assessing locomotion in novel activity monitors in CB1 receptor knockout mice and juxtaposed to habituation measured in muscarinic M2, M4, and double M2/M4 receptor knockout mice. M2 an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f56a1753abeedcfdf7d4c0196e09a46
https://doi.org/10.1016/j.bbr.2005.02.018
https://doi.org/10.1016/j.bbr.2005.02.018
Publikováno v:
NeuroReport. 16:63-67
Environmental enrichment enhances learning and memory in both rodents and man. We examined the effect of active manipulation of a novel object (toy) on cognitive performance and acetylcholine (ACh) efflux in the hippocampus of rats. Animals exposed t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a405b668503c52e870002d3c5ba76f55
https://doi.org/10.1097/00001756-200501190-00015
https://doi.org/10.1097/00001756-200501190-00015
Autor:
George G. Nomikos, Aldemar Degroot
Publikováno v:
Neuropsychopharmacology. 30:391-400
Anxiety disorders may result from an overexpression of aversive memories. Evidence suggests that the hippocampal cholinergic system could be the point of convergence of anxiety and memory. We propose that clinically effective anxiolytics may exert th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a408b0c9dc9a95101d4c666b788199d4
https://doi.org/10.1038/sj.npp.1300624
https://doi.org/10.1038/sj.npp.1300624
Autor:
Dallas Treit, Aldemar Degroot
Publikováno v:
Brain Research. 1001:60-71
Previous lesion studies have suggested that the septal-hippocampal system is involved in fear and anxiety. In this study we examined the effects on anxiety of temporary neuronal inhibition of various aspects of the septo-hippocampal system in rats. I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f76a7750f22d8188e8800626da494ba
https://doi.org/10.1016/j.brainres.2003.10.065
https://doi.org/10.1016/j.brainres.2003.10.065
Publikováno v:
Brain Research. 979:71-77
Activation of septal GABA receptors impairs learning and memory and this effect likely involves an influence on the hippocampus. We found previously that the memory-impairing effects of septal infusions of the GABA agonist muscimol are reversed by hi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d208c6a8a138499501415cf802910955
https://doi.org/10.1016/s0006-8993(03)02868-3
https://doi.org/10.1016/s0006-8993(03)02868-3