Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Aldema Sas-Chen"'
Autor:
Pedro Rebelo-Guiomar, Simone Pellegrino, Kyle C. Dent, Aldema Sas-Chen, Leonor Miller-Fleming, Caterina Garone, Lindsey Van Haute, Jack F. Rogan, Adam Dinan, Andrew E. Firth, Byron Andrews, Alexander J. Whitworth, Schraga Schwartz, Alan J. Warren, Michal Minczuk
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Rebelo-Guiomar et al. unveil late stage assembly intermediates of the human mitochondrial ribosome by inactivating the methyltransferase MRM2 in cells. Absence of MRM2 impairs organismal homeostasis, while its catalytic activity is dispensable for mi
Externí odkaz:
https://doaj.org/article/b26a6648dba14e5181a35583967acaa7
Autor:
Aldema Sas‐Chen, Miriam R Aure, Limor Leibovich, Silvia Carvalho, Yehoshua Enuka, Cindy Körner, Maria Polycarpou‐Schwarz, Sara Lavi, Nava Nevo, Yuri Kuznetsov, Justin Yuan, Francisco Azuaje, Oslo Breast Cancer Research Consortium (OSBREAC), Igor Ulitsky, Sven Diederichs, Stefan Wiemann, Zohar Yakhini, Vessela N Kristensen, Anne‐Lise Børresen‐Dale, Yosef Yarden, Torill Sauer, Jürgen Geisler, Solveig Hofvind, Tone F Bathen, Elin Borgen, Olav Engebråten, Øystein Fodstad, Øystein Garred, Gry Aarum Geitvik, Rolf Kåresen, Bjørn Naume, Gunhild Mari Mælandsmo, Hege G Russnes, Ellen Schlichting, Therese Sørlie, Ole Christian Lingjærde, Kristine Kleivi Sahlberg, Helle Kristine Skjerven, Britt Fritzman
Publikováno v:
EMBO Molecular Medicine, Vol 8, Iss 9, Pp 1052-1064 (2016)
Abstract Long noncoding RNAs (lncRNAs) are emerging as regulators of gene expression in pathogenesis, including cancer. Recently, lncRNAs have been implicated in progression of specific subtypes of breast cancer. One aggressive, basal‐like subtype
Externí odkaz:
https://doaj.org/article/4f7cfb1585b94dd5ac5eed26ab401081
Autor:
Aldema Sas-Chen, Eva Maria Novoa, Helaine Graziele Santos Vieira, Ivan Milenkovic, Huanle Liu, Sonia Cruciani, Rebeca Medina, Jose Miguel Ramirez, Leszek P. Pryszcz, John S. Mattick, Oguzhan Begik, Schraga Schwartz, Morghan C. Lucas
Publikováno v:
Nature Biotechnology. 39:1278-1291
Nanopore RNA sequencing shows promise as a method for discriminating and identifying different RNA modifications in native RNA. Expanding on the ability of nanopore sequencing to detect N6-methyladenosine, we show that other modifications, in particu
Autor:
Marie-line Bortolin-Cavaillé, Aurélie Quillien, Patrick Blader, Laurence Vandel, Sunny Sharma, Célia Plisson-Chastang, Justin M. Thomas, Jordan L. Meier, Schraga Schwartz, Aldema Sas-Chen, Jérôme Cavaillé, Supuni Thalalla Gamage, Denis L. J. Lafontaine
Publikováno v:
Nucleic Acids Research
Nucleic Acids Research, Oxford University Press, 2022, 50, pp.6284-6299. ⟨10.1093/nar/gkac404⟩
Nucleic Acids Research, Oxford University Press, 2022, 50, pp.6284-6299. ⟨10.1093/nar/gkac404⟩
NAT10 is an essential enzyme that catalyzes the formation of N4-acetylcytidine (ac4C) in eukaryotic transfer RNA (tRNA) and 18S ribosomal RNA (rRNA). Recent studies in human cells suggested that rRNA acetylation is dependent on SNORD13, a non-canonic
Autor:
Supuni Thalalla Gamage, Marie-Line Bortolin-Cavaillé, Courtney Link, Keri Bryson, Aldema Sas-Chen, Schraga Schwartz, Jérôme Cavaillé, Jordan L. Meier
N4-acetylcytidine (ac4C) is an RNA nucleobase found in all domains of life. Establishment of ac4C in helix 45 (h45) of human 18S ribosomal RNA (rRNA) requires the combined activity of the acetyltransferase NAT10 and the box C/D snoRNA SNORD13. Howeve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7539d383e5f470b53e3d9564f499fed
https://doi.org/10.1101/2022.05.12.491732
https://doi.org/10.1101/2022.05.12.491732
Autor:
Ronit Nir, Thomas Philipp Hoernes, Hiromi Muramatsu, Klaus Faserl, Katalin Karikó, Matthias David Erlacher, Aldema Sas-Chen, Schraga Schwartz
Publikováno v:
Nucleic acids research. 50(9)
RNA can be extensively modified post-transcriptionally with >170 covalent modifications, expanding its functional and structural repertoire. Pseudouridine (Ψ), the most abundant modified nucleoside in rRNA and tRNA, has recently been found within mR
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2192
RNA modifications are present in most cellular RNAs and are formed posttranscriptionally by enzymatic machineries that involve hundreds of enzymes and cofactors. RNA modifications impact the life cycle of the RNA, its stability, folding, cellular loc
Autor:
Oguzhan, Begik, Morghan C, Lucas, Leszek P, Pryszcz, Jose Miguel, Ramirez, Rebeca, Medina, Ivan, Milenkovic, Sonia, Cruciani, Huanle, Liu, Helaine Graziele Santos, Vieira, Aldema, Sas-Chen, John S, Mattick, Schraga, Schwartz, Eva Maria, Novoa
Publikováno v:
Nature biotechnology. 39(10)
Nanopore RNA sequencing shows promise as a method for discriminating and identifying different RNA modifications in native RNA. Expanding on the ability of nanopore sequencing to detect N
Autor:
John S. Mattick, Ivan Milenkovic, Leszek P. Pryszcz, Aldema Sas-Chen, Eva Maria Novoa, Helaine Graziele Santos Vieira, Sonia Cruciani, Huanle Liu, Rebeca Medina, Morghan C. Lucas, Oguzhan Begik, Schraga Schwartz, Jose Miguel Ramirez
A broad diversity of modifications decorate RNA molecules. Originally conceived as static components, evidence is accumulating that some RNA modifications may be dynamic, contributing to cellular responses to external signals and environmental circum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4c866fce4946b097dd56616f9ec6f960
https://doi.org/10.1101/2020.07.06.189969
https://doi.org/10.1101/2020.07.06.189969