The implications of allosteric sites on SH3-mediated signaling

Autor: Aldehaiman, Abdullah

A remarkable number of cellular processes are mediated by kinases. Many of these signaling pathways involve sarcoma homology 3 (SH3) domain interactions. Due to the high number and sequence conservation of SH3 domains in proteins, the interactions be

Externí odkaz: http://hdl.handle.net/10754/679220

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Cancer-associated mutations in the p85α N-terminal SH2 domain activate a spectrum of receptor tyrosine kinases.

Autor: Xinran Li, Lau, Amy Y. T., Ng, Angel S. N., Aldehaiman, Abdullah, Yuan Zhou, Ng, Patrick K. S., Arold, Stefan T., Cheung, Lydia W. T.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America; 9/14/2021, Vol. 118 Issue 37, p1-11, 11p

Functional selection in SH3-mediated activation of the PI3 kinase.

Autor: Aljedani SS; Biological and Environmental Science and Engineering Division, Computational Biology Research Center, King Abdullah University of Science and Technology (KAUST), Thuwal 2395-56900, Kingdom of Saudi Arabia., Aldehaiman A; Biological and Environmental Science and Engineering Division, Computational Biology Research Center, King Abdullah University of Science and Technology (KAUST), Thuwal 2395-56900, Kingdom of Saudi Arabia., Sandholu A; Biological and Environmental Science and Engineering Division, Computational Biology Research Center, King Abdullah University of Science and Technology (KAUST), Thuwal 2395-56900, Kingdom of Saudi Arabia., Alharbi S; Biological and Environmental Science and Engineering Division, Computational Biology Research Center, King Abdullah University of Science and Technology (KAUST), Thuwal 2395-56900, Kingdom of Saudi Arabia., Mak VCY; School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China., Wu H; Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, New York, USA., Lugari A; CRCM, CNRS, INSERM, Institut Paoli-Calmettes, Aix-Marseille University, 13009 Marseille, France., Jaremko M; Biological and Environmental Science and Engineering Division, Computational Biology Research Center, King Abdullah University of Science and Technology (KAUST), Thuwal 2395-56900, Kingdom of Saudi Arabia., Morelli X; CRCM, CNRS, INSERM, Institut Paoli-Calmettes, Aix-Marseille University, 13009 Marseille, France., Backer JW; Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, New York, USA., Ladbury JE; School of Molecular and Cellular Biology, and Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, LS2 9JT., Nowakowski M; Faculty of Chemistry, Biological and Chemical Research Centre, University of Warsaw, Żwirki i Wigury 101, 02-089 Warsaw, Poland., Cheung LWT; School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China., Arold ST; Biological and Environmental Science and Engineering Division, Computational Biology Research Center, King Abdullah University of Science and Technology (KAUST), Thuwal 2395-56900, Kingdom of Saudi Arabia.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Apr 30. Date of Electronic Publication: 2024 Apr 30.