Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Aldara Martin-Alonso"'
The vagus nerve mediates the physiological but not pharmacological effects of PYY3-36 on food intake
Autor:
Aldara Martin Alonso, Simon C. Cork, Phyllis Phuah, Benjamin Hansen, Mariana Norton, Sijing Cheng, Xiang Xu, Kinga Suba, Yue Ma, Georgina KC. Dowsett, John A. Tadross, Brian YH. Lam, Giles SH. Yeo, Herbert Herzog, Stephen R. Bloom, Myrtha Arnold, Walter Distaso, Kevin G. Murphy, Victoria Salem
Publikováno v:
Molecular Metabolism, Vol 81, Iss , Pp 101895- (2024)
Peptide YY (PYY3-36) is a post-prandially released gut hormone with potent appetite-reducing activity, the mechanism of action of which is not fully understood. Unravelling how this system physiologically regulates food intake may help unlock its the
Externí odkaz:
https://doaj.org/article/8ca434c5412d4079a5b6bb6f4eff13e9
Autor:
Sara Fontanella, Lisa G. Gregory, Luisa Polo Silveira, Aldara Martin Alonso, Clare M. Lloyd, Polly F. M. Robinson, Daphne Kaya-de Vries, Adnan Custovic, James Cook, Andrew Bush, Sachin Ananth, Sejal Saglani, Louise Fleming
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 204:523-535
Rationale: Preschool wheezing is heterogeneous, but the underlying mechanisms are poorly understood. Objectives: To investigate lower airway inflammation and infection in preschool children with different clinical diagnoses undergoing elective bronch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4fc07204b5efcaa75d9382e19977949
https://doi.org/10.1164/rccm.202009-3696oc
https://doi.org/10.1164/rccm.202009-3696oc
Autor:
Aldara Martin Alonso, Sejal Saglani
Publikováno v:
Frontiers in Pediatrics, Vol 5 (2017)
Although a rare disease, severe therapy-resistant asthma in children is a cause of significant morbidity and results in utilization of approximately 50% of health-care resources for asthma. Improving control for children with severe asthma is, theref
Externí odkaz:
https://doaj.org/article/6cc1d803a69e40c2a484ab2c8d6bde6a
Autor:
Frank Reimann, Anna Roberts, Aldara Martin Alonso, Mariana Norton, Victoria Salem, Wenhan Chang, Fiona M. Gribble, Kevin Murphy, Ye Cao
Publikováno v:
Endocrine Abstracts.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ef77f4ce5f038651527977aea54c5fa9
https://doi.org/10.1530/endoabs.77.ec1.4
https://doi.org/10.1530/endoabs.77.ec1.4
Autor:
Tatiana Lopes, Alejandra Tomas, Victoria Salem, Stavroula Bitsi, Yateen Patel, Usama Ali, Kinga Suba, Stephen Rothery, Isabelle Leclerc, Guy A. Rutter, Aldara Martin Alonso, Bryn M. Owen
Publikováno v:
Diabetes. 69
Aims: Long-term outcomes for islet transplantation remain suboptimal. An important determinant of islet transplantation success is vascularisation of engrafted islets. The epidermal growth factor receptor (EGFR) is a key angiogenic and pro-survival f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c9a60f0ac3f9502de4726c18955b82f5
https://doi.org/10.2337/db20-1683-p
https://doi.org/10.2337/db20-1683-p
Autor:
Rebecca Scott, James Minnion, Kinga Suba, Yateen Patel, Victoria Salem, Stephen R. Bloom, Guy A. Rutter, Walter Distaso, Bryn M. Owen, Tricia Tan, Kevin Murphy, Isabelle Leclerc, Aldara Martin Alonso
Publikováno v:
Diabetes. 69
Aims: GLP-1 (GLP-1R) and glucagon (GCGR) receptor co-agonists are in development to treat type 2 diabetes. The effect of chronic GCGR agonism on weight loss is well-documented, but its direct influence on islet function remains poorly understood. We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1a29ce607da3edfca456b742b0dccaf1
https://doi.org/10.2337/db20-1798-p
https://doi.org/10.2337/db20-1798-p
Autor:
Yue Ma, Walter Distaso, Myrtha Arnold, Victoria Salem, Simon C. Cork, Aldara Martin Alonso, Stephen R. Bloom, Kevin Murphy, Herbert Herzog
Publikováno v:
Journal of the Endocrine Society
Background: Drugs that safely promote weight loss are required to treat the obesity crisis. The gut hormone peptide YY 3-36 (PYY3-36) is secreted post-prandially to suppress appetite via the Y2 receptor (Y2R). However, it is unclear whether PYY3-36 a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::268e6115e2e7dd579fe00ab78b2fc5dd
http://europepmc.org/articles/PMC7207319
http://europepmc.org/articles/PMC7207319
Autor:
Mariana Norton, Aylin C. Hanyaloglu, Sijing Cheng, Anna Roberts, Victoria Salem, Kevin Murphy, Ye Cao, Aldara Martin Alonso, Yateen Patel, Wenhan Chang, Robert Hansford, Simon C. Cork
Publikováno v:
Journal of the Endocrine Society
The existence of a vago-vagal entero-pancreatic pathway, where sensory information from the gut can signal via vagal afferents to the brain to mediate changes in pancreatic function, has been recognised for over a century, and investigated extensivel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf1467fcd3e4c9995c215ee99dcda7c5
https://doi.org/10.1210/jendso/bvaa046.1776
https://doi.org/10.1210/jendso/bvaa046.1776
Autor:
Polly F. M. Robinson, Sara Fontanella, Sachin Ananth, Aldara Martin Alonso, James Cook, Daphne Kaya de Vries, Luisa Polo Silveira, Lisa Gregory, Clare Lloyd, Louise Fleming, Andrew Bush, Adnan Custovic, Sejal Saglani
Publikováno v:
SSRN Electronic Journal.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::399e1d94552b21bd18cd8bd76434c06f
https://doi.org/10.2139/ssrn.3690357
https://doi.org/10.2139/ssrn.3690357
Publikováno v:
Expert Review of Respiratory Medicine. 11:867-874
Introduction: Paediatric severe therapy resistant asthma (STRA) affects a very small proportion of all children with asthma, but results in significant morbidity, has a high risk of mortality and utilises approximately half of all healthcare resource
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55331c48966267f7cd7976d111223e63
https://doi.org/10.1080/17476348.2017.1368391
https://doi.org/10.1080/17476348.2017.1368391