Novel Bispidine-Monoterpene Conjugates—Synthesis and Application as Ligands for the Catalytic Ethylation of Chalcones

Autor: Evgeniy V. Suslov, Konstantin Y. Ponomarev, Oxana S. Patrusheva, Sergey O. Kuranov, Alina A. Okhina, Artem D. Rogachev, Aldar A. Munkuev, Roman V. Ottenbacher, Alexander I. Dalinger, Mikhail A. Kalinin, Sergey Z. Vatsadze, Konstantin P. Volcho, Nariman F. Salakhutdinov

Publikováno v: Molecules, Vol 26, Iss 24, p 7539 (2021)

A number of new chiral bispidines containing monoterpenoid fragments have been obtained. The bispidines were studied as ligands for Ni-catalyzed addition of diethylzinc to chalcones. The conditions for chromatographic analysis by HPLC-UV were develop

Externí odkaz: https://doaj.org/article/24d498af424d4ac98892b5e3ea3dd2d1

The Development of Tyrosyl-DNA Phosphodiesterase 1 Inhibitors. Combination of Monoterpene and Adamantine Moieties via Amide or Thioamide Bridges

Autor: Arina A. Chepanova, Evgenii S. Mozhaitsev, Aldar A. Munkuev, Evgeniy V. Suslov, Dina V. Korchagina, Olga D. Zakharova, Alexandra L. Zakharenko, Jinal Patel, Daniel M. Ayine-Tora, Jóhannes Reynisson, Ivanhoe K. H. Leung, Konstantin P. Volcho, Nariman F. Salakhutdinov, Olga I. Lavrik

Publikováno v: Applied Sciences, Vol 9, Iss 13, p 2767 (2019)

Eleven amide and thioamide derivatives with monoterpene and adamantine substituents were synthesised. They were tested for their activity against the tyrosyl-DNA phosphodiesterase 1 DNA (Tdp1) repair enzyme with the most potent compound 47a, having a

Externí odkaz: https://doaj.org/article/92b8b4f0a5c6449d9c35e20ff3c53ebf

Novel Tdp1 Inhibitors Based on Adamantane Connected with Monoterpene Moieties via Heterocyclic Fragments

Autor: Arina A Chepanova, Nadezhda S Dyrkheeva, E. V. Suslov, Alexandra L. Zakharenko, Ekaterina S Ilina, Dina V. Korchagina, Olga I. Lavrik, Konstantin P. Volcho, Jóhannes Reynisson, Olga D. Zakharova, Aldar A. Munkuev, Nariman F. Salakhutdinov, E. S. Mozhaitsev

Publikováno v: Molecules, Vol 26, Iss 3128, p 3128 (2021)
Molecules
Volume 26
Issue 11

Tyrosyl-DNA phosphodiesterase 1 (Tdp1) is a promising target for anticancer therapy due to its ability to counter the effects topoisomerase 1 (Top1) poison, such as topotecan, thus, decreasing their efficacy. Compounds containing adamantane and monot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe13b13c207597b51cb37482a6790c39
https://www.mdpi.com/1420-3049/26/11/3128

The Development of Tyrosyl-DNA Phosphodiesterase 1 Inhibitors. Combination of Monoterpene and Adamantine Moieties via Amide or Thioamide Bridges

Autor: Dina V. Korchagina, Konstantin P. Volcho, E. V. Suslov, Alexandra L. Zakharenko, Aldar A. Munkuev, Jóhannes Reynisson, Daniel M Ayine-Tora, Jinal Patel, Ivanhoe K. H. Leung, N.F. Salakhutdinov, E. S. Mozhaitsev, Arina A Chepanova, Olga I. Lavrik, Olga D. Zakharova

Publikováno v: Applied Sciences
Volume 9
Issue 13
Applied Sciences, Vol 9, Iss 13, p 2767 (2019)

Eleven amide and thioamide derivatives with monoterpene and adamantine substituents were synthesised. They were tested for their activity against the tyrosyl-DNA phosphodiesterase 1 DNA (Tdp1) repair enzyme with the most potent compound 47a, having a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac84e5226e43554a86c3d87ec32cab3d
https://eprints.keele.ac.uk/6666/1/applsci-09-02767-v2.pdf

Elaboration of the Effective Multi-Target Therapeutic Platform for the Treatment of Alzheimer's Disease Based on Novel Monoterpene-Derived Hydroxamic Acids.

Autor: Aleksandrova Y; Institute of Physiologically Active Compounds at Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, Severnij Pr. 1, Chernogolovka 142432, Russia., Munkuev A; Department of Medicinal Chemistry, N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch, Russian Academy of Sciences, Lavrentiev Ave., 9, Novosibirsk 630090, Russia., Mozhaitsev E; Department of Medicinal Chemistry, N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch, Russian Academy of Sciences, Lavrentiev Ave., 9, Novosibirsk 630090, Russia., Suslov E; Department of Medicinal Chemistry, N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch, Russian Academy of Sciences, Lavrentiev Ave., 9, Novosibirsk 630090, Russia., Tsypyshev D; Department of Medicinal Chemistry, N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch, Russian Academy of Sciences, Lavrentiev Ave., 9, Novosibirsk 630090, Russia., Chaprov K; Institute of Physiologically Active Compounds at Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, Severnij Pr. 1, Chernogolovka 142432, Russia., Begunov R; Biology and Ecology Faculty of P. G. Demidov Yaroslavl State University, Matrosova Ave., 9, Yaroslavl 150003, Russia., Volcho K; Department of Medicinal Chemistry, N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch, Russian Academy of Sciences, Lavrentiev Ave., 9, Novosibirsk 630090, Russia., Salakhutdinov N; Department of Medicinal Chemistry, N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch, Russian Academy of Sciences, Lavrentiev Ave., 9, Novosibirsk 630090, Russia., Neganova M; Institute of Physiologically Active Compounds at Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, Severnij Pr. 1, Chernogolovka 142432, Russia.

Publikováno v: International journal of molecular sciences [Int J Mol Sci] 2023 Jun 04; Vol. 24 (11). Date of Electronic Publication: 2023 Jun 04.