Brucella abortus RNA does not polarize macrophages to a particular profile but interferes with M1 polarization.

Autor: Agustina Serafino, José L Marin Franco, Mariano Maio, Aldana Trotta, Melanie Genoula, Luis A Castillo, Federico Birnberg Weiss, José R Pittaluga, Luciana Balboa, Paula Barrionuevo, M Ayelén Milillo

Publikováno v: PLoS Neglected Tropical Diseases, Vol 16, Iss 11, p e0010950 (2022)

Monocytes and macrophages play a central role in chronic brucellosis. Brucella abortus (Ba) is an intracellular pathogen that survives inside these cells. On the other hand, macrophages could be differentiated into classical (M1), alternative (M2) or

Externí odkaz: https://doaj.org/article/d0c1db2870e24a83a782cd0aaf663ffa

Bacterial RNA Contributes to the Down-Modulation of MHC-II Expression on Monocytes/Macrophages Diminishing CD4+ T Cell Responses

Autor: M. Ayelén Milillo, Aldana Trotta, Agustina Serafino, José Luis Marin Franco, Fábio V. Marinho, Julieta Alcain, Melanie Genoula, Luciana Balboa, Sergio Costa Oliveira, Guillermo H. Giambartolomei, Paula Barrionuevo

Publikováno v: Frontiers in Immunology, Vol 10 (2019)

Brucella abortus, the causative agent of brucellosis, displays many resources to evade T cell responses conducive to persist inside the host. Our laboratory has previously showed that infection of human monocytes with B. abortus down-modulates the IF

Externí odkaz: https://doaj.org/article/a30c7fe1d2514ce590db3947c8295e72

Platelets Promote Brucella abortus Monocyte Invasion by Establishing Complexes With Monocytes

Autor: Aldana Trotta, Lis N. Velásquez, M. Ayelén Milillo, M. Victoria Delpino, Ana M. Rodríguez, Verónica I. Landoni, Guillermo H. Giambartolomei, Roberto G. Pozner, Paula Barrionuevo

Publikováno v: Frontiers in Immunology, Vol 9 (2018)

Brucellosis is an infectious disease elicited by bacteria of the genus Brucella. Platelets have been extensively described as mediators of hemostasis and responsible for maintaining vascular integrity. Nevertheless, they have been recently involved i

Externí odkaz: https://doaj.org/article/1d5abb9254e4442fbc398a182875beee

SLAMF1 signaling induces Mycobacterium tuberculosis uptake leading to endolysosomal maturation in human macrophages

Autor: Angela María Barbero, Luciana Balboa, Federico Fuentes, Verónica E. García, Josefina Celano, Aldana Trotta, Martin A. Estermann, Paula Barrionuevo, Rodrigo Emanuel Hernández Del Pino, Melanie Genoula, Virginia Pasquinelli

Publikováno v: Journal of Leukocyte Biology. 109:257-273

Tuberculosis dates back to ancient times but it is not a problem of the past. Each year, millions of people die from tuberculosis. After inhalation of infectious droplet nuclei, Mycobacterium tuberculosis reaches the lungs where it can manipulate the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a6a44ebbac8b2b2c28beb7e3f15cfaf
https://doi.org/10.1002/jlb.4ma0820-655rr

Brucella abortus-Stimulated Platelets Activate Brain Microvascular Endothelial Cells Increasing Cell Transmigration through the Erk1/2 Pathway

Autor: M. Victoria Delpino, Kwang Sik Kim, M. Cruz Miraglia, Agustina P. Melnyczajko, Aldana Trotta, Ana M. Rodríguez, Paula Barrionuevo, Guillermo H. Giambartolomei

Publikováno v: Pathogens, Vol 9, Iss 708, p 708 (2020)
Pathogens
Volume 9
Issue 9
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

Central nervous system invasion by bacteria of the genus Brucella results in an inflammatory disorder called neurobrucellosis. A common feature associated with this pathology is blood&ndash
brain barrier (BBB) activation. However, the underlying

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0937e1616ffb708f297e6531e811c61a
https://www.mdpi.com/2076-0817/9/9/708