Zobrazeno 1 - 10
of 104
pro vyhledávání: '"Alclofenac"'
Publikováno v:
Chem Res Toxicol
Electrophilically reactive drug metabolites are implicated in many adverse drug reactions. In this mechanism—termed bioactivation—metabolic enzymes convert drugs into reactive metabolites that often conjugate to nucleophilic sites within biologic
Publikováno v:
International Journal of Pharmaceutics. 126:95-102
Ten non-steroidal anti-inflammatory drugs (NSAID) of the acetic and propionic classes were analyzed in the form of salts to disclose the solubilization property of their aqueous solutions toward a lipid probe (the azo-dye Orange OT). This property is
Publikováno v:
Journal of Veterinary Pharmacology and Therapeutics. 17:353-358
Concentrations of the non-steroidal anti-inflammatory drug (NSAID) alclofenac were determined by a sensitive high performance liquid chromatographic procedure in plasma and urine of horses following oral administration of a dose of 3 g. In plasma, al
Publikováno v:
Journal of Chromatography B: Biomedical Sciences and Applications. 621:209-214
A high-performance liquid chromatographic method to measure plasma and urinary alclofenac levels in equine biofluids is described. Isolation of the drug from plasma is achieved using liquid-liquid extraction with diethyl ether. Reversed-phase C18 sol
Publikováno v:
Drug Delivery System. 8:121-129
The in vitro skin permeation using hairless mouse and in vivo skin absorption using rat of alclofenac from ethanol/panasate 800 (tricaprylin) binary vehicle were investigated. The in vitro skin permeability of alclofenac was remarkably enhanced by th
Publikováno v:
Journal of Bioactive and Compatible Polymers. 6:129-141
Macromolecular prodrugs of a hydrophilic polymer [α,β-poly( N- hydroxyethyl)-DL-aspartamide (PHEA)] was used as a drug carrier. Three poly- (HEA)-NSAID adducts were studied: poly(HEA)-Alclofenac, poly(HEA)-Keto profen, and poly(HEA)-Ibuprofen. Prod
Autor:
S Kishore, Meenakshi Maruthamuthu
Publikováno v:
Proceedings / Indian Academy of Sciences. 103:173-183
The binding data for the interaction of alclofenac (AF) and dansylsarcosine (DS) to bovine serum albumin (BSA) have respectively yielded nonlinear Scatchard plots. The plots have been subjected to Rosenthal’s method of analysis and thus the ligands
Publikováno v:
Electrophoresis. 20(9)
So far, most capillary electrophoresis (CE) separationshave been carried out in aqueous or, to a lesser extent,mixed aqueous–organic media. Organic solvents havemainly been used in micellar electrokinetic chromatogra-phy (MEKC) and in capillary ele
Publikováno v:
Biologicalpharmaceutical bulletin. 16(12)
The effects of an ethanol/panasate 800 (tricaprylin) (40/60) system as a lipophilic vehicle, and an ethanol/water (60/40) system as a hydrophilic vehicle, with or without permeation enhancers for in vitro skin permeation and in vivo skin absorption o
Publikováno v:
Biologicalpharmaceutical bulletin. 16(2)
The novel binary vehicle system consisting of ethanol (EtOH) and Panasate 800 as tricaprylin was applied to five types of nonsteroidal anti-inflammatory drugs, and its enhancing effect on drug permeation across hairless mouse skin in vitro was assess