Zobrazeno 1 - 10
of 276
pro vyhledávání: '"Alcino J, Silva"'
Autor:
Fernando M. C. V. Reis, Sandra Maesta-Pereira, Matthias Ollivier, Peter J. Schuette, Ekayana Sethi, Blake A. Miranda, Emily Iniguez, Meghmik Chakerian, Eric Vaughn, Megha Sehgal, Darren C. T. Nguyen, Faith T. H. Yuan, Anita Torossian, Juliane M. Ikebara, Alexandre H. Kihara, Alcino J. Silva, Jonathan C. Kao, Baljit S. Khakh, Avishek Adhikari
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract Investigative exploration and foraging leading to food consumption have vital importance, but are not well-understood. Since GABAergic inputs to the lateral and ventrolateral periaqueductal gray (l/vlPAG) control such behaviors, we dissected
Externí odkaz:
https://doaj.org/article/4e031cdf54ec4e9b950c2226c8049dd1
Autor:
Manuel F. López-Aranda, Karen Bach, Raymond Bui, Miranda Phan, Odilia Lu, Chirag Thadani, Alessandro Luchetti, Rochelle Mandanas, Isaiah Herrera, María Dolores López-Ávalos, Alcino J. Silva
Publikováno v:
Biomedicines, Vol 12, Iss 1, p 203 (2024)
There is evidence that viral infections during pre-natal development constitute a risk factor for neuropsychiatric disorders and lead to learning and memory deficits. However, little is known about why viral infections during early post-natal develop
Externí odkaz:
https://doaj.org/article/94263560706040ad9f19037073b7e9c6
Publikováno v:
Molecular Brain, Vol 15, Iss 1, Pp 1-19 (2022)
Abstract Systems neuroscience is focused on how ensemble properties in the brain, such as the activity of neuronal circuits, gives rise to internal brain states and behavior. Many of the studies in this field have traditionally involved electrophysio
Externí odkaz:
https://doaj.org/article/8155d3cab5ba4562958c3fd4bdd17874
Science is growing at a pace that exceeds our comprehension. This is no less true of neuroscience than any other discipline. Ambiguity about what is known and what has been disproven confounds researchers and hampers research planning. There are simp
Publikováno v:
Frontiers in Psychology, Vol 13 (2022)
A kind of “ruthless reductionism” characterized the experimental practices of the first two decades of molecular and cellular cognition (MCC). More recently, new research tools have expanded experimental practices in this field, enabling research
Externí odkaz:
https://doaj.org/article/bd742d63a3cb4ec5b23b86e06fa9a8dc
Publikováno v:
IEEE Access, Vol 9, Pp 97929-97941 (2021)
Scientists try to design experiments that will yield maximal information. For instance, given the available evidence and a limitation on the number of variables that can be observed simultaneously, it may be more informative to intervene on variable
Externí odkaz:
https://doaj.org/article/6bed86bd2452499fa9cb071726d13a39
Autor:
Weisheng Wang, Peter J Schuette, Mimi Q La-Vu, Anita Torossian, Brooke C Tobias, Marta Ceko, Philip A Kragel, Fernando MCV Reis, Shiyu Ji, Megha Sehgal, Sandra Maesta-Pereira, Meghmik Chakerian, Alcino J Silva, Newton S Canteras, Tor Wager, Jonathan C Kao, Avishek Adhikari
Publikováno v:
eLife, Vol 10 (2021)
Escape from threats has paramount importance for survival. However, it is unknown if a single circuit controls escape vigor from innate and conditioned threats. Cholecystokinin (cck)-expressing cells in the hypothalamic dorsal premammillary nucleus (
Externí odkaz:
https://doaj.org/article/7333c19037ed4e3bbeb22847fc8ed52e
Autor:
Stavros Stivaros, Shruti Garg, Maria Tziraki, Ying Cai, Owen Thomas, Joseph Mellor, Andrew A. Morris, Carly Jim, Karolina Szumanska-Ryt, Laura M Parkes, Hamied A. Haroon, Daniela Montaldi, Nicholas Webb, John Keane, Francisco X. Castellanos, Alcino J. Silva, Sue Huson, Stephen Williams, D. Gareth Evans, Richard Emsley, Jonathan Green, SANTA Consortium
Publikováno v:
Molecular Autism, Vol 9, Iss 1, Pp 1-13 (2018)
Abstract Background Neurofibromatosis 1 (NF1) is a monogenic model for syndromic autism. Statins rescue the social and cognitive phenotype in animal knockout models, but translational trials with subjects > 8 years using cognition/behaviour outcomes
Externí odkaz:
https://doaj.org/article/dafd5e775ca6491c9657b16a73c4e0fa
Autor:
Adam C. Frank, Shan Huang, Miou Zhou, Amos Gdalyahu, George Kastellakis, Tawnie K. Silva, Elaine Lu, Ximiao Wen, Panayiota Poirazi, Joshua T. Trachtenberg, Alcino J. Silva
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Structural remodeling of dendritic spines is thought to be a mechanism of memory storage. Here, the authors look at how spine turnover and clustering predict future learning and memory performance, and see that a genetically modified mouse with enhan
Externí odkaz:
https://doaj.org/article/9812b8e6055c436ab27e845c4f6d0c38
Autor:
Joana Gonçalves, Inês R. Violante, José Sereno, Ricardo A. Leitão, Ying Cai, Antero Abrunhosa, Ana Paula Silva, Alcino J. Silva, Miguel Castelo-Branco
Publikováno v:
Molecular Autism, Vol 8, Iss 1, Pp 1-8 (2017)
Abstract Background Excitation/inhibition (E/I) imbalance remains a widely discussed hypothesis in autism spectrum disorders (ASD). The presence of such an imbalance may potentially define a therapeutic target for the treatment of cognitive disabilit
Externí odkaz:
https://doaj.org/article/3383b8df02da4f888b419fbaa5beed83