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Akademický článek

GNE-064: A Potent, Selective, and Orally Bioavailable Chemical Probe for the Bromodomains of SMARCA2 and SMARCA4 and the Fifth Bromodomain of PBRM1.

Autor: Taylor AM; Constellation, a Morphosys Company, 215 First Street, Suite 200, Cambridge, Massachusetts 02142, United States., Bailey C; Constellation, a Morphosys Company, 215 First Street, Suite 200, Cambridge, Massachusetts 02142, United States., Belmont LD; Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States., Campbell R; Constellation, a Morphosys Company, 215 First Street, Suite 200, Cambridge, Massachusetts 02142, United States., Cantone N; Constellation, a Morphosys Company, 215 First Street, Suite 200, Cambridge, Massachusetts 02142, United States., Côté A; Constellation, a Morphosys Company, 215 First Street, Suite 200, Cambridge, Massachusetts 02142, United States., Crawford TD; Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States., Cummings R; Constellation, a Morphosys Company, 215 First Street, Suite 200, Cambridge, Massachusetts 02142, United States., DeMent K; Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States., Duplessis M; Constellation, a Morphosys Company, 215 First Street, Suite 200, Cambridge, Massachusetts 02142, United States., Flynn M; Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States., Good AC; Constellation, a Morphosys Company, 215 First Street, Suite 200, Cambridge, Massachusetts 02142, United States., Huang HR; Constellation, a Morphosys Company, 215 First Street, Suite 200, Cambridge, Massachusetts 02142, United States., Joshi S; Constellation, a Morphosys Company, 215 First Street, Suite 200, Cambridge, Massachusetts 02142, United States., Leblanc Y; Constellation, a Morphosys Company, 215 First Street, Suite 200, Cambridge, Massachusetts 02142, United States., Murray J; Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States., Nasveschuk CG; Constellation, a Morphosys Company, 215 First Street, Suite 200, Cambridge, Massachusetts 02142, United States., Neiss A; Constellation, a Morphosys Company, 215 First Street, Suite 200, Cambridge, Massachusetts 02142, United States., Poy F; Constellation, a Morphosys Company, 215 First Street, Suite 200, Cambridge, Massachusetts 02142, United States., Romero FA; Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States., Sandy P; Constellation, a Morphosys Company, 215 First Street, Suite 200, Cambridge, Massachusetts 02142, United States., Tang Y; Constellation, a Morphosys Company, 215 First Street, Suite 200, Cambridge, Massachusetts 02142, United States., Tsui V; Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States., Zawadzke L; Constellation, a Morphosys Company, 215 First Street, Suite 200, Cambridge, Massachusetts 02142, United States., Sims RJ 3rd; Constellation, a Morphosys Company, 215 First Street, Suite 200, Cambridge, Massachusetts 02142, United States., Audia JE; Constellation, a Morphosys Company, 215 First Street, Suite 200, Cambridge, Massachusetts 02142, United States., Bellon SF; Constellation, a Morphosys Company, 215 First Street, Suite 200, Cambridge, Massachusetts 02142, United States., Magnuson SR; Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States., Albrecht BK; Constellation, a Morphosys Company, 215 First Street, Suite 200, Cambridge, Massachusetts 02142, United States., Cochran AG; Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2022 Aug 25; Vol. 65 (16), pp. 11177-11186. Date of Electronic Publication: 2022 Aug 05.

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Akademický článek

Design and Synthesis of Styrenylcyclopropylamine LSD1 Inhibitors.

Autor: Gehling VS; Constellation Pharmaceuticals, 215 First Street, Suite 200, Cambridge, Massachusetts 02142, United States., McGrath JP; Constellation Pharmaceuticals, 215 First Street, Suite 200, Cambridge, Massachusetts 02142, United States., Duplessis M; Constellation Pharmaceuticals, 215 First Street, Suite 200, Cambridge, Massachusetts 02142, United States., Khanna A; Constellation Pharmaceuticals, 215 First Street, Suite 200, Cambridge, Massachusetts 02142, United States., Brucelle F; Constellation Pharmaceuticals, 215 First Street, Suite 200, Cambridge, Massachusetts 02142, United States., Vaswani RG; Constellation Pharmaceuticals, 215 First Street, Suite 200, Cambridge, Massachusetts 02142, United States., Côté A; Constellation Pharmaceuticals, 215 First Street, Suite 200, Cambridge, Massachusetts 02142, United States., Stuckey J; Constellation Pharmaceuticals, 215 First Street, Suite 200, Cambridge, Massachusetts 02142, United States., Watson V; Constellation Pharmaceuticals, 215 First Street, Suite 200, Cambridge, Massachusetts 02142, United States., Cummings RT; Constellation Pharmaceuticals, 215 First Street, Suite 200, Cambridge, Massachusetts 02142, United States., Balasubramanian S; Constellation Pharmaceuticals, 215 First Street, Suite 200, Cambridge, Massachusetts 02142, United States., Iyer P; Constellation Pharmaceuticals, 215 First Street, Suite 200, Cambridge, Massachusetts 02142, United States., Sawant P; Constellation Pharmaceuticals, 215 First Street, Suite 200, Cambridge, Massachusetts 02142, United States., Good AC; Constellation Pharmaceuticals, 215 First Street, Suite 200, Cambridge, Massachusetts 02142, United States., Albrecht BK; Constellation Pharmaceuticals, 215 First Street, Suite 200, Cambridge, Massachusetts 02142, United States., Harmange JC; Constellation Pharmaceuticals, 215 First Street, Suite 200, Cambridge, Massachusetts 02142, United States., Audia JE; Constellation Pharmaceuticals, 215 First Street, Suite 200, Cambridge, Massachusetts 02142, United States., Bellon SF; Constellation Pharmaceuticals, 215 First Street, Suite 200, Cambridge, Massachusetts 02142, United States., Trojer P; Constellation Pharmaceuticals, 215 First Street, Suite 200, Cambridge, Massachusetts 02142, United States., Levell JR; Constellation Pharmaceuticals, 215 First Street, Suite 200, Cambridge, Massachusetts 02142, United States.

Publikováno v: ACS medicinal chemistry letters [ACS Med Chem Lett] 2020 May 06; Vol. 11 (6), pp. 1213-1220. Date of Electronic Publication: 2020 May 06 (Print Publication: 2020).

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Akademický článek

GNE-371, a Potent and Selective Chemical Probe for the Second Bromodomains of Human Transcription-Initiation-Factor TFIID Subunit 1 and Transcription-Initiation-Factor TFIID Subunit 1-like.

Autor: Wang S; Genentech Inc. , 1 DNA Way , South San Francisco , California 94080 , United States., Tsui V; Genentech Inc. , 1 DNA Way , South San Francisco , California 94080 , United States., Crawford TD; Genentech Inc. , 1 DNA Way , South San Francisco , California 94080 , United States., Audia JE; Constellation Pharmaceuticals , 215 First Street, Suite 200 , Cambridge , Massachusetts 02142 , United States., Burdick DJ; Genentech Inc. , 1 DNA Way , South San Francisco , California 94080 , United States., Beresini MH; Genentech Inc. , 1 DNA Way , South San Francisco , California 94080 , United States., Côté A, Cummings R; Constellation Pharmaceuticals , 215 First Street, Suite 200 , Cambridge , Massachusetts 02142 , United States., Duplessis M; Constellation Pharmaceuticals , 215 First Street, Suite 200 , Cambridge , Massachusetts 02142 , United States., Flynn EM; Genentech Inc. , 1 DNA Way , South San Francisco , California 94080 , United States., Hewitt MC; Constellation Pharmaceuticals , 215 First Street, Suite 200 , Cambridge , Massachusetts 02142 , United States., Huang HR; Constellation Pharmaceuticals , 215 First Street, Suite 200 , Cambridge , Massachusetts 02142 , United States., Jayaram H; Constellation Pharmaceuticals , 215 First Street, Suite 200 , Cambridge , Massachusetts 02142 , United States., Jiang Y; Wuxi Apptec Company, Ltd. , 288 Fute Zhong Road , Waigaoqiao Free Trade Zone, Shanghai 200131 , People's Republic of China., Joshi S; Constellation Pharmaceuticals , 215 First Street, Suite 200 , Cambridge , Massachusetts 02142 , United States., Murray J; Genentech Inc. , 1 DNA Way , South San Francisco , California 94080 , United States., Nasveschuk CG; Constellation Pharmaceuticals , 215 First Street, Suite 200 , Cambridge , Massachusetts 02142 , United States., Pardo E; Constellation Pharmaceuticals , 215 First Street, Suite 200 , Cambridge , Massachusetts 02142 , United States., Poy F; Constellation Pharmaceuticals , 215 First Street, Suite 200 , Cambridge , Massachusetts 02142 , United States., Romero FA; Genentech Inc. , 1 DNA Way , South San Francisco , California 94080 , United States., Tang Y; Constellation Pharmaceuticals , 215 First Street, Suite 200 , Cambridge , Massachusetts 02142 , United States., Taylor AM; Constellation Pharmaceuticals , 215 First Street, Suite 200 , Cambridge , Massachusetts 02142 , United States., Wang J; Wuxi Apptec Company, Ltd. , 288 Fute Zhong Road , Waigaoqiao Free Trade Zone, Shanghai 200131 , People's Republic of China., Xu Z; Wuxi Apptec Company, Ltd. , 288 Fute Zhong Road , Waigaoqiao Free Trade Zone, Shanghai 200131 , People's Republic of China., Zawadzke LE; Constellation Pharmaceuticals , 215 First Street, Suite 200 , Cambridge , Massachusetts 02142 , United States., Zhu X; Wuxi Apptec Company, Ltd. , 288 Fute Zhong Road , Waigaoqiao Free Trade Zone, Shanghai 200131 , People's Republic of China., Albrecht BK; Constellation Pharmaceuticals , 215 First Street, Suite 200 , Cambridge , Massachusetts 02142 , United States., Magnuson SR; Genentech Inc. , 1 DNA Way , South San Francisco , California 94080 , United States., Bellon S; Constellation Pharmaceuticals , 215 First Street, Suite 200 , Cambridge , Massachusetts 02142 , United States., Cochran AG; Genentech Inc. , 1 DNA Way , South San Francisco , California 94080 , United States.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2018 Oct 25; Vol. 61 (20), pp. 9301-9315. Date of Electronic Publication: 2018 Oct 05.

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