Výsledky vyhledávání - "Albiruni R A, Razak"

Akademický článek

Tumor reactive γδ T cells contribute to a complete response to PD-1 blockade in a Merkel cell carcinoma patient

Autor: Scott C. Lien, Dalam Ly, S. Y. Cindy Yang, Ben X. Wang, Derek L. Clouthier, Michael St. Paul, Ramy Gadalla, Babak Noamani, Carlos R. Garcia-Batres, Sarah Boross-Harmer, Philippe L. Bedard, Trevor J. Pugh, Anna Spreafico, Naoto Hirano, Albiruni R. A. Razak, Pamela S. Ohashi

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)

Abstract Immunotherapies targeting PD-1/PD-L1 are now widely used in the clinic to treat a variety of malignancies. While most of the research on T cell exhaustion and PD-1 blockade has been focused on conventional αβ T cells, the contribution of i

Externí odkaz: https://doaj.org/article/fd59752fa86742a8a6eab34aa0b37b3b

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Akademický článek

Impact on costs and outcomes of multi-gene panel testing for advanced solid malignancies: a cost-consequence analysis using linked administrative dataResearch in context

Publikováno v: EClinicalMedicine, Vol 69, Iss , Pp 102443- (2024)

Summary: Background: To date, economic analyses of tissue-based next generation sequencing genomic profiling (NGS) for advanced solid tumors have typically required models with assumptions, with little real-world evidence on overall survival (OS), cl

Externí odkaz: https://doaj.org/article/19ab2f66fed24a75a727e76111c21e84

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Akademický článek

Autoimmune PaneLs as PrEdictors of Toxicity in Patients TReated with Immune Checkpoint InhibiTors (ALERT)

Publikováno v: Journal of Experimental & Clinical Cancer Research, Vol 42, Iss 1, Pp 1-13 (2023)

Abstract Background Immune-checkpoint inhibitors (ICI) can lead to immune-related adverse events (irAEs) in a significant proportion of patients. The mechanisms underlying irAEs development are mostly unknown and might involve multiple immune effecto

Externí odkaz: https://doaj.org/article/b47044a90bde498cb63139e5570ed22f

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Akademický článek

Lineage-defined leiomyosarcoma subtypes emerge years before diagnosis and determine patient survival

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)

Heterogeneity in leiomyosarcomas (LMS) makes treatment of the disease challenging. Here the authors analyze LMS heterogeneity and molecular LMS subtypes using genomics and transcriptomics, finding origins in distinct lineages and associations with su

Externí odkaz: https://doaj.org/article/c08bf52065ac4dcd90672db6a2810128

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Akademický článek

Quality of life of patients with soft tissue sarcoma treated with doxorubicin in the ANNOUNCE phase III clinical trial

Autor: Brian A Van Tine MD, PhD, Anders Krarup-Hansen MD, PhD, Lisa M Hess PhD, Albiruni R Abdul Razak MD, Victoria Soldatenkova MSc, Jennifer Wright MD, Se Hoon Park MD

Publikováno v: Rare Tumors, Vol 14 (2022)

Background: Patient-reported outcomes (PROs), including health-related quality of life, are recommended to be routinely collected in clinical trials, but data are limited from trials of sarcoma patients. In this analysis, pooled PRO data are reported

Externí odkaz: https://doaj.org/article/eeb8b1752f264cfaa1ea44fc9c3eb400

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Akademický článek

Cancer patients’ experiences with immune checkpoint modulators: A qualitative study

Autor: Kari Ala‐Leppilampi, Natalie A. Baker, Chris McKillop, Marcus O. Butler, Lillian L. Siu, Anna Spreafico, Albiruni R. Abdul Razak, Anthony M. Joshua, David Hogg, Philippe L. Bedard, Natasha Leighl, Amit M. Oza, Janet A. Parsons, Aaron R. Hansen

Publikováno v: Cancer Medicine, Vol 9, Iss 9, Pp 3015-3022 (2020)

Abstract Background Minimal qualitative data exist on the experiences of cancer patients treated with immune checkpoint inhibitors or costimulatory antibodies. Understanding the day to day experiences of patients being treated with immune checkpoint

Externí odkaz: https://doaj.org/article/791284663301419f8555fe2acf46ac6b

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Akademický článek

Systemic and local immunity following adoptive transfer of NY-ESO-1 SPEAR T cells in synovial sarcoma

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1, Pp 1-14 (2019)

Abstract Background Gene-modified autologous T cells expressing NY-ESO-1c259, an affinity-enhanced T-cell receptor (TCR) reactive against the NY-ESO-1-specific HLA-A*02-restricted peptide SLLMWITQC (NY-ESO-1 SPEAR T-cells; GSK 794), have demonstrated

Externí odkaz: https://doaj.org/article/08dda14b5f1b4ef08600740b083a4b11

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Akademický článek

An interim report on the investigator-initiated phase 2 study of pembrolizumab immunological response evaluation (INSPIRE)

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1, Pp 1-12 (2019)

Abstract Background Immune checkpoint inhibitors (ICIs) demonstrate unprecedented efficacy in multiple malignancies; however, the mechanisms of sensitivity and resistance are poorly understood and predictive biomarkers are scarce. INSPIRE is a phase

Externí odkaz: https://doaj.org/article/31ba8dd2f028423db6db252c1c7723fb

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