Zobrazeno 1 - 10
of 102
pro vyhledávání: '"Albinterferon"'
Autor:
Timothy T. Bergsma, A. Corey, Daniel S. Stein, Matt N. Devalaraja, Haiying Sun, Matthew M. Riggs, G. Mani Subramanian, Jing Yu, James A. Rogers, Marc R. Gastonguay, Cecil Chen
Publikováno v:
The Journal of Clinical Pharmacology. 52:475-486
Albinterferon alfa-2b (albIFN) has been studied for treatment of chronic hepatitis C virus (HCV). A population pharmacokinetics model was developed using nonlinear mixed-effects modeling. Efficacy/safety exposure-response relationships were assessed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::468e96ec05414dc559fd367afd1720b6
https://doi.org/10.1177/0091270011399576
https://doi.org/10.1177/0091270011399576
Autor:
Teerha Piratvisuth, Yali Li, Stephen Pianko, Samir Shah, Robert Flisiak, G. Feutren, Graham R. Foster, Jens Rasenack, Michael K. Gould, Shiv Kumar Sarin, Ira M. Jacobson, Pietro Andreone, Piyawat Komolmit, M. Pang, Tawesak Tanwandee, Satawat Thongsawat, Stefan Zeuzem, C.-M. Lee, Wan-Lung Chuang, Y. Yin, Jacob George, Ajit Sood
Publikováno v:
Journal of Viral Hepatitis. 19:623-634
Albinterferon alfa-2b (albIFN) is a fusion protein of recombinant human albumin/recombinant interferon (IFN)-α-2b, with ∼200-h half-life. Safety/efficacy of albIFN q4wk was evaluated in 391 treatment-naive patients with chronic hepatitis C virus (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d39fe3c8f61925ae327569889be5d5bf
https://doi.org/10.1111/j.1365-2893.2012.01586.x
https://doi.org/10.1111/j.1365-2893.2012.01586.x
Autor:
Thi Sau Migone, Vijayan Balan, Erik Pulkstenis, David R. Nelson, G. Mani Subramanian, Robert D. Abelson, Vinod K. Rustgi, Michele Fiscella
Publikováno v:
Hepatology Research. 39:455-462
The pharmacodynamics of albinterferon alfa-2b (alb-IFN), a novel recombinant protein consisting of interferon-α-2b genetically fused to human albumin, was evaluated in patients with chronic hepatitis C with a previous non-response to interferon-α-b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f3687dc5f4b6c6eb46666c401b8850b
https://doi.org/10.1111/j.1872-034x.2008.00475.x
https://doi.org/10.1111/j.1872-034x.2008.00475.x
Autor:
Jens Praestgaard, Richard Colvin, Hong Ren, Wan-Long Chuang, Ruobing Li, Abhasnee Sobhonslidsuk, Teerha Piratvisuth, Satawat Thongsawat, Hongfei Zhang, Junfang Xu, Yi Han, Daniel S. Stein, Aric J. Hui, Yin Qi, Tawesak Tanwandee, Pei-Jer Chen
Publikováno v:
Journal of Gastroenterology and Hepatology. 30:184-191
Background and Aims Albinterferon is a fusion of albumin and interferon-α2b developed to improve the pharmacokinetics, convenience, and potential efficacy of interferon-α for the treatment of chronic hepatitis infections. Methods This open-label, r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d73a4516c714d2295503c45ea4195a14
https://doi.org/10.1111/jgh.12671
https://doi.org/10.1111/jgh.12671
Autor:
Angela W. Blake-Haskins, Kristin B. O'berry, Pinaki Basu, Theodore W. Randolph, John F. Carpenter
Publikováno v:
Journal of Pharmaceutical Sciences. 103:427-436
Silicone oil used as a lubricant in prefilled syringes has the potential to induce formation of particles in protein formulations. In the current study, we used a therapeutic fusion protein, albinterferon α2b , to evaluate protein aggregation and pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d23bcb2643ab1accc5250827b6056883
https://doi.org/10.1002/jps.23821
https://doi.org/10.1002/jps.23821
Publikováno v:
Hepatology Research. 37:941-947
BACKGROUND Interferon-based combination therapy is the standard treatment for chronic hepatitis C virus (HCV) infection. The weekly administration of long-acting pegylated interferons (PEG-IFNalpha-2a or PEG-IFNalpha-2b) provides superior antiviral e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d38e79047ba428543f17280716961f65
https://doi.org/10.1111/j.1872-034x.2007.00142.x
https://doi.org/10.1111/j.1872-034x.2007.00142.x
Autor:
Haiying Sun, Jing Yu, Wan-Long Chuang, Maria Pang, Shiv Kumar Sarin, Robert Flisiak, Daniel S. Stein
Publikováno v:
Anti-Infective Agents. 12:58-67
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d490e8e25d61276a3cf0fb88476345e8
https://doi.org/10.2174/22113525113119990108
https://doi.org/10.2174/22113525113119990108
Publikováno v:
Medical Science and Technology. 55:31-36
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5793b2836943a4f6103032514db54ec1
https://doi.org/10.12659/mst.889286
https://doi.org/10.12659/mst.889286
Autor:
Henry Masur, Bart L. Haagmans, Michael A. Polis, Eva Herrmann, Shyam Kottilil, Seerat Poonia, Amy Nelson, Yu-Jin Lee, Richard A. Lempicki, Anu Osinusi, Michael C. Sneller, Dimitra Bon, Shu Yi Cai, Bhavana Shivakumar, Brad Wood
Publikováno v:
Journal of Medical Virology. 86:177-185
The effect of different formulations of interferon on therapeutic response in patients coinfected with HIV and HCV is unclear. In this study, the safety, tolerability, viral kinetics (VK) modeling and host responses among HIV/HCV coinfected patients
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ca16f2c22b5240ca3dd8e211b7db6941
https://doi.org/10.1002/jmv.23773
https://doi.org/10.1002/jmv.23773
Autor:
Alexander J. Thompson, Erik Pulkstenis, Stephen Pianko, Stefan Zeuzem, Mark S. Sulkowski, David R. Nelson, Yves Benhamou, Robert Flisiak, John G. McHutchison, Eric Lawitz, Vinod K. Rustgi, Graham R. Foster, Michael Torbenson, Wan-Long Chuang, Moisés Diago, Keyur Patel, Maribel Rodriguez-Torres, G. Mani Subramanian, Sanjeev Arora
Publikováno v:
Gut. 61:128-134
Genotype-specific associations between hepatitis C virus (HCV) and insulin resistance (IR) have been described, but a causal relationship remains unclear. This study investigated the association between a sustained virological response (SVR) and IR a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70bf017feda06d3c56ffae314d5caba8
https://doi.org/10.1136/gut.2010.236158
https://doi.org/10.1136/gut.2010.236158