Intraoperative visualization of nerves using a myelin protein-zero specific fluorescent tracer

Autor: Tessa Buckle, Albertus. W. Hensbergen, Danny M. van Willigen, Frank Bosse, Kevin Bauwens, Rob C. M. Pelger, Fijs W. B. van Leeuwen

Publikováno v: EJNMMI Research, Vol 11, Iss 1, Pp 1-13 (2021)

Abstract Background Surgically induced nerve damage is a common but debilitating side effect in oncological surgery. With the aim to use fluorescence guidance to enable nerve-sparing interventions in future surgery, a fluorescent tracer was developed

Externí odkaz: https://doaj.org/article/ee186526bcc244d69c58062a80db8563

Hybrid Tracers Based on Cyanine Backbones Targeting Prostate-Specific Membrane Antigen: Tuning Pharmacokinetic Properties and Exploring Dye-Protein Interaction

Autor: Margret Schottelius, Henk G. van der Poel, Gabri van der Pluijm, Mick M. Welling, Albertus W. Hensbergen, Wytske M. van Weerden, Hans-Jürgen Wester, Fijs W. B. van Leeuwen, Felicia A. van der Wijk, Danny M. van Willigen, Tobias Maurer, Tessa Buckle

Publikováno v: Journal of Nuclear Medicine, 61(2), 234-241. Society of Nuclear Medicine and Molecular Imaging
Journal of Nuclear Medicine, 61(2), 234-241. SOC NUCLEAR MEDICINE INC

Prostate cancer surgery is currently being revolutionized by the use of prostate-specific membrane antigen (PSMA)-targeted radiotracers, for example, (99)mTc-labeled PSMA tracer analogs for radioguided surgery. The purpose of this study was to develo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8667a811e6c40e56d96ca47b09e5fa42
https://doi.org/10.2967/jnumed.119.233064

Interventional nuclear medicine: 'click' chemistry as an in vivo targeting strategy for imaging microspheres and bacteria

Autor: D.M. van Willigen, Mick M. Welling, Nikolas Duszenko, D.D.D. Rietbergen, F.W.B. van Leeuwen, Meta Roestenberg, Albertus W. Hensbergen, Tessa Buckle

Publikováno v: Biomaterials Science
Biomaterials Science, 9(5), 1683-1690. ROYAL SOC CHEMISTRY

Aim: Pre-targeting is a proven strategy for in vivo delivery of a diagnostic or therapeutic payload. The pre-targeting concept can be realized through various conjugation strategies, one of which is based on copper-free "click" chemistry. Copper-free

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2afcce6e8a9884a696ae1a1727ba21ad
https://hdl.handle.net/1887/3214702

Click Chemistry in the Design and Production of Hybrid Tracers

Autor: Margret Schottelius, Felicia A. van der Wijk, Danny M. van Willigen, Mick M. Welling, Clarize M. de Korne, Matthias N. van Oosterom, Albertus W. Hensbergen, Hans-Jürgen Wester, Fijs W. B. van Leeuwen, Tessa Buckle

Publikováno v: ACS Omega, 4(7), 12438-12448
ACS Omega, Vol 4, Iss 7, Pp 12438-12448 (2019)
ACS Omega

Hybrid tracers containing both fluorescent and radioactive imaging labels have demonstrated clinical potential during sentinel lymph node procedures. To combine these two labels on a single targeting vector that allows tumor-targeted imaging, end-lab

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf5289bb3db6c6c1fecab2b4005ae7a4
https://hdl.handle.net/1887/121271

Computational and experimental data on electrostatic density and stacking tendency of asymmetric cyanine 5 dyes

Autor: S. van der Wal, Albertus W. Hensbergen, Joeri Kuil, F.W.B. van Leeuwen, Silvia J. Spa

Publikováno v: Data in Brief 22 (2019)
Data in Brief, Vol 22, Iss, Pp 50-55 (2019)
Data in Brief, 22, 50-55
Data in Brief

Far-red dyes such as cyanine 5 (Cy5) are gaining interest in (bio)medical diagnostics as they have promising features in terms of stability and brightness. Here, the electrostatic density and stacking tendency in different solvents of nine systematic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4676a438ecf5a048a3554ae6f67e4c65
https://research.wur.nl/en/publications/computational-and-experimental-data-on-electrostatic-density-and-