Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Alberto Purwada"'
Autor:
F. Apoorva, Alexander M. Loiben, Shivem B. Shah, Alberto Purwada, Lorena Fontan, Rebecca Goldstein, Brian J. Kirby, Ari M. Melnick, Benjamin D. Cosgrove, Ankur Singh
Publikováno v:
Cell Reports, Vol 23, Iss 2, Pp 499-511 (2018)
Summary: The role of microenvironment-mediated biophysical forces in human lymphomas remains elusive. Diffuse large B cell lymphomas (DLBCLs) are heterogeneous tumors, which originate from highly proliferative germinal center B cells. These tumors, t
Externí odkaz:
https://doaj.org/article/b8014b7db1d94f98a656beefa4823cd8
Autor:
Wendy Béguelin, Martín A. Rivas, María T. Calvo Fernández, Matt Teater, Alberto Purwada, David Redmond, Hao Shen, Matt F. Challman, Olivier Elemento, Ankur Singh, Ari M. Melnick
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
The histone methyltransferase EZH2 silences genes by generating H3K27me3 marks. Here the authors use a 3D GC organoid and show EZH2 mediates germinal centre (GC) formation through epigenetic silencing of CDKN1A and release of cell cycle checkpoints.
Externí odkaz:
https://doaj.org/article/3b2ffd3bcb4b423ea05a96db979141c5
Autor:
James K. Carrow, Prachi Desai, Rebecca S. Schneider, Anjana Venkataramanan, Manish K. Jaiswal, Akhilesh K. Gaharwar, Ankur Singh, Alberto Purwada
Publikováno v:
Journal of Biomedical Materials Research Part A. 106:2048-2058
Nanoparticle shape has emerged as a key regulator of nanoparticle transport across physiological barriers, intracellular uptake, and biodistribution. We report a facile approach to synthesize ellipsoidal nanoparticles through self-assembly of poly(gl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0ec2a67e21593709eb958a7e07b9f6c
https://doi.org/10.1002/jbm.a.36400
https://doi.org/10.1002/jbm.a.36400
Autor:
Ankur Singh, Alberto Purwada, Rebecca Goldstein, Lorena Fontan, Brian Kirby, Benjamin D. Cosgrove, Fnu Apoorva, Alexander M. Loiben, Shivem B. Shah, Ari Melnick
Publikováno v:
Cell reports
Cell Reports, Vol 23, Iss 2, Pp 499-511 (2018)
Cell Reports, Vol 23, Iss 2, Pp 499-511 (2018)
Summary The role of microenvironment-mediated biophysical forces in human lymphomas remains elusive. Diffuse large B cell lymphomas (DLBCLs) are heterogeneous tumors, which originate from highly proliferative germinal center B cells. These tumors, th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ff49d035c8a2cd36d94eb1909140ebe
http://europepmc.org/articles/PMC5965297
http://europepmc.org/articles/PMC5965297
Autor:
Hao Shen, Wendy Béguelin, Matt F. Challman, Alberto Purwada, Matt Teater, Ankur Singh, María Fernández, Ari Melnick, David Redmond, Olivier Elemento, Martín A. Rivas
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
Nature Communications
Nature Communications
The EZH2 histone methyltransferase is required for B cells to form germinal centers (GC). Here we show that EZH2 mediates GC formation through repression of cyclin-dependent kinase inhibitor CDKN1A (p21Cip1). Deletion of Cdkn1a rescues the GC reactio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d83d200c524d3f124ed14dc03707c81b
https://doaj.org/article/3b2ffd3bcb4b423ea05a96db979141c5
https://doaj.org/article/3b2ffd3bcb4b423ea05a96db979141c5
Publikováno v:
ACS Biomaterials Science & Engineering. 3:214-225
Germinal centers are dynamic structures within lymphoid tissues, which develop once B cells receive activating signals from surrounding immune cells. Germinal center B cells are small in number, heterogeneous, and prone to rapid apoptosis unless sele
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6c4a0f78b55a998db086084efb90d8b
https://doi.org/10.1021/acsbiomaterials.6b00474
https://doi.org/10.1021/acsbiomaterials.6b00474
Autor:
Ankur Singh, Alberto Purwada
Publikováno v:
Nature Protocols
Induction of B-cell immunity against infection depends on the initiation of the germinal center (GC) reaction in secondary lymphoid organs. Ex vivo recapitulation of the GC reaction in 2D cultures results in transient cell growth, with poor yield and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5436272317c097c17d1b8c7160d5d86
Most antigen discovery and vaccine development aimed at driving functional B cell responses rely on mouse immunizations studies. To date, there is no 3D ex vivo immune tissues, which are capable of driving antigen-specific B cell responses to rapidly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04257c4ec151e18ab02b0cb465ac473e
https://europepmc.org/articles/PMC6355359/
https://europepmc.org/articles/PMC6355359/
Autor:
Olga V. Sazonova, Alberto Purwada, Jo Ann Buczek-Thomas, Brett C. Isenberg, Joyce Wong, Jacob Herrmann, Kristen L. Lee, Matthew A. Nugent, Alexander D. Valentine
Publikováno v:
Matrix Biology. 41:36-43
The development of atherosclerosis involves phenotypic changes among vascular smooth muscle cells (VSMCs) that correlate with stiffening and remodeling of the extracellular matrix (ECM). VSMCs are highly sensitive to the composition and mechanical st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d2c8bbb761584aeeb7dba25ef0a7062
https://doi.org/10.1016/j.matbio.2014.11.001
https://doi.org/10.1016/j.matbio.2014.11.001
Autor:
Ari Melnick, Giorgio Inghirami, Ravi G. Patel, Akhilesh K. Gaharwar, Leandro Cerchietti, Alberto Purwada, Ankur Singh
Publikováno v:
Cellular and Molecular Bioengineering. 7:394-408
Bioengineered hydrogels have been explored in cell and tissue engineering applications to support cell growth and modulate its behavior. A rationally designed scaffold should allow for encapsulated cells to survive, adhere, proliferate, remodel the n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4164a31008e6d94de102178305b1ced2
https://doi.org/10.1007/s12195-014-0353-8
https://doi.org/10.1007/s12195-014-0353-8