Zobrazeno 1 - 10
of 195
pro vyhledávání: '"Alberto Pugliese"'
Autor:
Peter S. Linsley, Maki Nakayama, Elisa Balmas, Janice Chen, Fariba Barahmand-pour-Whitman, Shubham Bansal, Ty Bottorff, Elisavet Serti, Cate Speake, Alberto Pugliese, Karen Cerosaletti
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Human type 1 diabetes (T1D) is caused by autoimmune attack on the insulin-producing pancreatic beta cells by islet antigen-reactive T cells. How human islet antigen-reactive (IAR) CD4+ memory T cells from peripheral blood affect T1D progress
Externí odkaz:
https://doaj.org/article/66f2c80699f6498b86e42acf78ab840a
Autor:
George William Burke, Alla Mitrofanova, Antonio Miguel Fontanella, Francesco Vendrame, Gaetano Ciancio, Rodrigo M. Vianna, David Roth, Phillip Ruiz, Carolyn L. Abitbol, Jayanthi Chandar, Sandra Merscher, Alberto Pugliese, Alessia Fornoni
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Beyond the direct benefit that a transplanted organ provides to an individual recipient, the study of the transplant process has the potential to create a better understanding of the pathogenesis, etiology, progression and possible therapy for recurr
Externí odkaz:
https://doaj.org/article/1b7a873155f94756acfcd5372875e429
Autor:
Sherman S. Leung, Nataliya Lenchik, Clayton Mathews, Alberto Pugliese, Domenica A. McCarthy, Selena Le Bagge, Adam Ewing, Mark Harris, Kristen J. Radford, Danielle J. Borg, Ivan Gerling, Josephine M. Forbes
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-15 (2023)
Abstract Hypoglycemia in type 1 diabetes associates with changes in the pancreatic islet α cells, where the receptor for advanced glycation end products (RAGE) is highly expressed. This study compared islet RAGE expression in donors without diabetes
Externí odkaz:
https://doaj.org/article/1e61b2e4072243548923a79cf1259cab
Autor:
Daniel J. Perry, Melanie R. Shapiro, Sonya W. Chamberlain, Irina Kusmartseva, Srikar Chamala, Leandro Balzano-Nogueira, Mingder Yang, Jason O. Brant, Maigan Brusko, MacKenzie D. Williams, Kieran M. McGrail, James McNichols, Leeana D. Peters, Amanda L. Posgai, John S. Kaddis, Clayton E. Mathews, Clive H. Wasserfall, Bobbie-Jo M. Webb-Robertson, Martha Campbell-Thompson, Desmond Schatz, Carmella Evans-Molina, Alberto Pugliese, Patrick Concannon, Mark S. Anderson, Michael S. German, Chester E. Chamberlain, Mark A. Atkinson, Todd M. Brusko
Publikováno v:
Scientific Data, Vol 10, Iss 1, Pp 1-16 (2023)
Abstract The Network for Pancreatic Organ donors with Diabetes (nPOD) is the largest biorepository of human pancreata and associated immune organs from donors with type 1 diabetes (T1D), maturity-onset diabetes of the young (MODY), cystic fibrosis-re
Externí odkaz:
https://doaj.org/article/0ad4cb66140840c5abd02c69201bad7b
Autor:
Huan Liu, Shirin Geravandi, Ausilia Maria Grasso, Saheri Sikdar, Alberto Pugliese, Kathrin Maedler
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2023)
IntroductionFor more than a century, enteroviral infections have been associated with autoimmunity and type 1 diabetes (T1D). Uncontrolled viral response pathways repeatedly presented during childhood highly correlate with autoimmunity and T1D. Virus
Externí odkaz:
https://doaj.org/article/ccaa7da97df2423c99adae5b434c9745
Autor:
Mirza Muhammad Fahd Qadir, Silvia Álvarez-Cubela, Jonathan Weitz, Julia K. Panzer, Dagmar Klein, Yaisa Moreno-Hernández, Sirlene Cechin, Alejandro Tamayo, Joana Almaça, Helmut Hiller, Maria Beery, Irina Kusmartseva, Mark Atkinson, Stephan Speier, Camillo Ricordi, Alberto Pugliese, Alejandro Caicedo, Christopher A. Fraker, Ricardo Luis Pastori, Juan Domínguez-Bendala
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
The ability to culture live pancreatic tissue slices for long periods of time would enable longitudinal studies ex vivo. Here the authors culture human and mouse pancreatic slices in a perfluorocarbon-based culture system and show stable endocrine an
Externí odkaz:
https://doaj.org/article/e297d8d44f204d96a98c13a905c50452
Autor:
Angelo Genoni, Filippo Canducci, Agostino Rossi, Francesco Broccolo, Konstantin Chumakov, Giorgio Bono, Jorge Salerno-Uriarte, Alessandro Salvatoni, Alberto Pugliese, Antonio Toniolo
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)
Abstract Enteroviruses (EVs) causing persisting infection are characterized by minimal replication and genetic changes. Typing of these agents may complement disease assessment and shed light on pathogenesis. Here we report an integrated approach for
Externí odkaz:
https://doaj.org/article/5331d48e6ec546f79f3bcc3a9521a0f1
Autor:
Ingvild S M Gabrielsen, Hanna Helgeland, Helle Akselsen, Hans Christian D Aass, Arvind Y M Sundaram, Isaac V Snowhite, Alberto Pugliese, Siri T Flåm, Benedicte A Lie
Publikováno v:
PLoS ONE, Vol 14, Iss 7, p e0218858 (2019)
Antigen presenting cells (APCs) in the thymus play an essential role in the establishment of central tolerance, i.e. the generation of a repertoire of functional and self-tolerant T cells to prevent autoimmunity. In this study, we have compared the t
Externí odkaz:
https://doaj.org/article/50b5ad82ae2a402593943a1922a860e2
Autor:
Mirza Muhammad Fahd Qadir, Silvia Álvarez-Cubela, Jonathan Weitz, Julia K. Panzer, Dagmar Klein, Yaisa Moreno-Hernández, Sirlene Cechin, Alejandro Tamayo, Joana Almaça, Helmut Hiller, Maria Beery, Irina Kusmartseva, Mark Atkinson, Stephan Speier, Camillo Ricordi, Alberto Pugliese, Alejandro Caicedo, Christopher A. Fraker, Ricardo Luis Pastori, Juan Domínguez-Bendala
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-1 (2020)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Externí odkaz:
https://doaj.org/article/2a1cc15a96f04c4e9605fe345f65874d
Autor:
Maarit Oikarinen, Lori Bertolet, Antonio Toniolo, Sami Oikarinen, Jutta E. Laiho, Alberto Pugliese, Richard E. Lloyd, Heikki Hyöty, the nPOD-V Study Group
Publikováno v:
Viruses, Vol 12, Iss 7, p 747 (2020)
Using immunohistochemistry, enterovirus capsid proteins were demonstrated in pancreatic islets of patients with type 1 diabetes. Virus proteins are mainly located in beta cells, supporting the hypothesis that enterovirus infections may contribute to
Externí odkaz:
https://doaj.org/article/10161f2277c148ebb35a35d8545968cd