Výsledky vyhledávání - "Alberto Parras"

Akademický článek

Initiation phase cellular reprogramming ameliorates DNA damage in the ERCC1 mouse model of premature aging

Autor: Patrick Treat Paine, Cheyenne Rechsteiner, Francesco Morandini, Gabriela Desdín-Micó, Calida Mrabti, Alberto Parras, Amin Haghani, Robert Brooke, Steve Horvath, Andrei Seluanov, Vera Gorbunova, Alejandro Ocampo

Publikováno v: Frontiers in Aging, Vol 4 (2024)

Unlike aged somatic cells, which exhibit a decline in molecular fidelity and eventually reach a state of replicative senescence, pluripotent stem cells can indefinitely replenish themselves while retaining full homeostatic capacity. The conferment of

Externí odkaz: https://doaj.org/article/3cf34d95781547ddadab3e678f935ae3

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Akademický článek

Impaired development of neocortical circuits contributes to the neurological alterations in DYRK1A haploinsufficiency syndrome

Autor: Juan Arranz, Elisa Balducci, Krisztina Arató, Gentzane Sánchez-Elexpuru, Sònia Najas, Alberto Parras, Elena Rebollo, Isabel Pijuan, Ionas Erb, Gaetano Verde, Ignasi Sahun, Maria J. Barallobre, José J. Lucas, Marina P. Sánchez, Susana de la Luna, Maria L. Arbonés

Publikováno v: Neurobiology of Disease, Vol 127, Iss , Pp 210-222 (2019)

Autism spectrum disorders are early onset neurodevelopmental disorders characterized by deficits in social communication and restricted repetitive behaviors, yet they are quite heterogeneous in terms of their genetic basis and phenotypic manifestatio

Externí odkaz: https://doaj.org/article/28d366b9092f47de8d16633beced1031

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Initiation phase cellular reprogramming ameliorates DNA damage in the ERCC1 mouse model of premature aging

Autor: Patrick Treat Paine, Cheyenne Rechsteiner, Francesco Morandini, Gabriela Desdin Mico, Calida Mrabti, Alberto Parras, Amin Haghani, Robert Brooke, Steve Horvath, Andrei Seluanov, Vera Gorbunova, Alejandro Ocampo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::92ee4e058983dfc493d27f2a8a834abc
https://doi.org/10.1101/2023.05.12.540500

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ERCC1 mice, unlike other premature aging models, display accelerated epigenetic age

Autor: Kevin Perez, Alberto Parras, Cheyenne Rechsteiner, Amin Haghani, Robert Brooke, Calida Mrabti, Lucas Schonfeldt, Steve Horvath, Alejandro Ocampo

Over the last decades, several premature aging mouse models have been developed to study aging and identify interventions that can delay age-related diseases. Yet, it is still unclear whether these models truly recapitulate natural aging. Here, we an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4faa6621d849089408aea533dffb3feb
https://doi.org/10.1101/2022.12.28.522011

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The P2X7 receptor contributes to seizures and inflammation-driven long-lasting brain hyperexcitability following neonatal hypoxia in mice

Autor: Jonathon Smith, Aida Menendez Mendez, Mariana Alves, Alberto Parras, Giorgia Conte, Anindya Bhattacharya, Marc Ceusters, Annette Nicke, David Henshall, Eva Jimenez-Mateos, Tobias Engel

Background and Purpose Neonatal seizures are a clinical emergency. Current anti-seizure medications, however, fail to resolve seizures in ~50% of infants. The P2X7 receptor (P2X7R) is an important driver of inflammation and evidence suggest P2X7R con

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a236409a011733c4968e8e2862afb255
https://doi.org/10.22541/au.166508305.54244816/v1

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Pathogenic mis-splicing of CPEB4 in schizophrenia

Autor: Ivana Ollà, Antonio F. Pardiñas, Alberto Parras, Ivó H. Hernández, María Santos-Galindo, Sara Picó, Luis F. Callado, Ainara Elorza, Gonzalo Fernández-Miranda, Eulàlia Belloc, James T.R. Walters, Michael C. O’Donovan, Claudio Toma, Raúl Méndez, J. Javier Meana, Michael J. Owen, José J. Lucas

Schizophrenia (SCZ) is caused by a complex interplay of polygenic risk and environmental factors, which might alter regulators of gene expression leading to pathogenic mis-expression of SCZ risk genes. The RNA binding protein family CPEB (CPEB1, CPEB

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::89bac7cfc91f3daa926970f074af78b3
https://doi.org/10.1101/2022.09.22.508890

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In vivo reprogramming leads to premature death due to hepatic and intestinal failure

Autor: Alberto Parras, Alba Vílchez-Acosta, Gabriela Desdín-Micó, Calida Mrabti, Cheyenne Rechsteiner, Fabrice Battiston, Clémence Branchina, Kevin Pérez, Christine Sempoux, Alejandro Ocampo

SUMMARYThe induction of cellular reprogramming by forced expression of the transcription factors OCT4, SOX2, KLF4, and C-MYC (OSKM) has been shown to allow the dedifferentiation of somatic cells and ameliorate age-associated phenotypes in multiple ti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::18b96c0d3986d23cfffb30538e637dc3
https://doi.org/10.1101/2022.05.27.493700

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CPEB alteration and aberrant transcriptome-polyadenylation lead to a treatable SLC19A3 deficiency in Huntington’s disease

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname
Dipòsit Digital de la UB
Universidad de Barcelona
SCIENCE TRANSLATIONAL MEDICINE
r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu

Huntington’s disease (HD) is a hereditary neurodegenerative disorder of the basal ganglia for which disease-modifying treatments are not yet available. Although gene-silencing therapies are currently being tested, further molecular mechanisms must

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::700c39064ed471d955598fbebb4fd6b0
http://hdl.handle.net/10261/266629

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