Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Alberto Pappalardo"'
Autor:
Gernot Neumayer, Jessica L. Torkelson, Shengdi Li, Kelly McCarthy, Hanson H. Zhen, Madhuri Vangipuram, Marius M. Mader, Gulilat Gebeyehu, Taysir M. Jaouni, Joanna Jacków-Malinowska, Avina Rami, Corey Hansen, Zongyou Guo, Sadhana Gaddam, Keri M. Tate, Alberto Pappalardo, Lingjie Li, Grace M. Chow, Kevin R. Roy, Thuylinh Michelle Nguyen, Koji Tanabe, Patrick S. McGrath, Amber Cramer, Anna Bruckner, Ganna Bilousova, Dennis Roop, Jean Y. Tang, Angela Christiano, Lars M. Steinmetz, Marius Wernig, Anthony E. Oro
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract We present Dystrophic Epidermolysis Bullosa Cell Therapy (DEBCT), a scalable platform producing autologous organotypic iPS cell-derived induced skin composite (iSC) grafts for definitive treatment. Clinical-grade manufacturing integrates CRI
Externí odkaz:
https://doaj.org/article/beaa5273b9ae4861a2bf161a05a28b1a
Autor:
Zongyou Guo, Chi‐Kun Tong, Joanna Jacków, Yanne S. Doucet, Hasan E. Abaci, Wangyong Zeng, Corey Hansen, Ryota Hayashi, Dominick DeLorenzo, Avina Rami, Alberto Pappalardo, Ellen A. Lumpkin, Angela M. Christiano
Publikováno v:
Bioengineering & Translational Medicine, Vol 7, Iss 1, Pp n/a-n/a (2022)
Abstract Atopic dermatitis (AD), driven by interleukins (IL‐4/IL‐13), is a chronic inflammatory skin disease characterized by intensive pruritus. However, it is unclear how immune signaling and sensory response pathways cross talk with each other
Externí odkaz:
https://doaj.org/article/e02dbcb9a03e4f028a42af44b195894e
A scalable, GMP-compatible, autologous organotypic cell therapy for Dystrophic Epidermolysis Bullosa
Autor:
Gernot Neumayer, Jessica L. Torkelson, Shengdi Li, Kelly McCarthy, Hanson H. Zhen, Madhuri Vangipuram, Joanna Jackow, Avina Rami, Corey Hansen, Zongyou Guo, Sadhana Gaddam, Alberto Pappalardo, Lingjie Li, Amber Cramer, Kevin R. Roy, Thuylinh Michelle Nguyen, Koji Tanabe, Patrick S. McGrath, Anna Bruckner, Ganna Bilousova, Dennis Roop, Irene Bailey, Jean Y. Tang, Angela Christiano, Lars M. Steinmetz, Marius Wernig, Anthony E. Oro
SummaryBackgroundGene editing in induced pluripotent stem (iPS) cells has been hailed to enable new cell therapies for various monogenetic diseases including dystrophic epidermolysis bullosa (DEB). However, manufacturing, efficacy and safety roadbloc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1895f5117a5ef80c9f76384a10d07cea
https://doi.org/10.1101/2023.02.28.529447
https://doi.org/10.1101/2023.02.28.529447
Autor:
Kacey Ronaldson-Bouchard, Diogo Teles, Keith Yeager, Daniel Naveed Tavakol, Yimu Zhao, Alan Chramiec, Somnath Tagore, Max Summers, Sophia Stylianos, Manuel Tamargo, Busub Marcus Lee, Susan P. Halligan, Erbil Hasan Abaci, Zongyou Guo, Joanna Jacków, Alberto Pappalardo, Jerry Shih, Rajesh K. Soni, Shivam Sonar, Carrie German, Angela M. Christiano, Andrea Califano, Karen K. Hirschi, Christopher S. Chen, Andrzej Przekwas, Gordana Vunjak-Novakovic
Publikováno v:
Nature Biomedical Engineering. 6:351-371
Engineered tissues can be used to model human pathophysiology and test the efficacy and safety of drugs. Yet, to model whole-body physiology and systemic diseases, engineered tissues with preserved phenotypes need to physiologically communicate. Here
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfc30fed8bf7563ff80aa6f1fd15e122
https://doi.org/10.1038/s41551-022-00882-6
https://doi.org/10.1038/s41551-022-00882-6
Autor:
Hasan Erbil Abaci, Mohammad Abdollahi, Nadia Aboutalebianaraki, Azadeh Izadyari Aghmiuni, Abdolreza Ahmadi, Navid Ahmadi Nasab, Abdullah Aldhaher, Nureddin Ashammakhi, Shokouh Attarilar, Alvarez Cespedes, Shu-Yung Chang, Terry Ching, Dong-Woo Cho, Won-Woo Cho, Muhammedin Deliorman, Mahmoud Ebrahimi, Yavuz Nuri Ertas, Maryam Ghaffari, Michinao Hashimoto, Fatemehsadat Hosseini, Motaharesadat Hosseini, Arman Jafari, Masoumeh Keshavarz, Saeed Heidari Keshel, Madisyn Messmore, Soheyl Mirzababaei, Kaylee Misiti, Mohammadmahdi Mobaraki, Maryam Mollazadeh-Bajestani, Ali Mousavi, Fathollah Moztarzadeh, Mona Navaei-Nigjeh, Xiaolei Nie, Alberto Pappalardo, Wonbin Park, Mohammad A. Qasaimeh, Mehdi Razavi, Kae Sato, Kiichi Sato, Houman Savoji, Fahimeh Shahabipour, Amir Shamloo, Angela Shar, Ghazal Shineh, Pavithra Sukumar, Safa Taherkhani, Yi-Chin Toh, Ha Linh Vu, Liqiang Wang, Hee-Gyeong Yi
Publikováno v:
Principles of Human Organs-on-Chips ISBN: 9780128235362
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d15c00a503f2a8516d8f1f046315fb02
https://doi.org/10.1016/b978-0-12-823536-2.01002-6
https://doi.org/10.1016/b978-0-12-823536-2.01002-6
Publikováno v:
Principles of Human Organs-on-Chips ISBN: 9780128235362
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f88a71d7a955f06f5dc9b17c55b020f2
https://doi.org/10.1016/b978-0-12-823536-2.00005-5
https://doi.org/10.1016/b978-0-12-823536-2.00005-5
Publikováno v:
Adv Wound Care (New Rochelle)
Objective: We compared the capability of human umbilical vein endothelial cells (HUVECs), induced pluripotent stem cell (iPSC)-derived endothelial cells (iECs), and human dermal blood endothelial cells (HDBECs) to effectively vascularize engineered h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::387c56e3e60501194c907a6b3f380410
https://doi.org/10.1089/wound.2020.1163
https://doi.org/10.1089/wound.2020.1163
Autor:
J. Jackow, David Alvarez Cespedes, David M. Owens, Angela M. Christiano, Rolando Perez-Lorenzo, Corey Hansen, Avina Rami, Alberto Pappalardo, D. Delorenzo, Zongyou Guo, Arianna L. Kim, R. Hayashi
Publikováno v:
Journal of Investigative Dermatology. 141:942-946
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc888920f42d30d79e58b64234550d6a
https://doi.org/10.1016/j.jid.2020.08.022
https://doi.org/10.1016/j.jid.2020.08.022
Autor:
B. Sallee, J. Shin, Hasan E. Abaci, Angela M. Christiano, Z. Guo, Alberto Pappalardo, Eddy Hsi Chun Wang, Y. Doucet, Joanna Jacków, Lauren Herron
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
Scientific Reports
Scientific Reports
Drug screening studies for inflammatory skin diseases are currently performed using model systems that only partially recapitulate human diseased skin. Here, we developed a new strategy to incorporate T cells into human 3D skin constructs (HSCs), whi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c84496ab929df9ddd141fbbb6aa4f1e2
http://link.springer.com/article/10.1038/s41598-020-60275-0
http://link.springer.com/article/10.1038/s41598-020-60275-0
Autor:
R. Hayashi, Hasan E. Abaci, Y. Doucet, D. Delorenzo, J. Jackow, Avina Rami, Chi-Kun Tong, Z. Guo, Angela M. Christiano, Corey Hansen, Wangyong Zeng, Alberto Pappalardo, Ellen A. Lumpkin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0f7e467f95d699cad4983f31235fe20c
https://doi.org/10.1002/btm2.10247/v2/response1
https://doi.org/10.1002/btm2.10247/v2/response1