Zobrazeno 1 - 10
of 398
pro vyhledávání: '"Alberto Ocaña"'
Autor:
María del Mar Noblejas-López, Elena García-Gil, Pedro Pérez-Segura, Atanasio Pandiella, Balázs Győrffy, Alberto Ocaña
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract Regulatory T cells (Tregs) is a subtype of CD4+ T cells that produce an inhibitory action against effector cells. In the present work we interrogated genomic datasets to explore the transcriptomic profile of breast tumors with high expressio
Externí odkaz:
https://doaj.org/article/74224a059ba148d49dfab9e6ca39f072
Autor:
Silvia Sánchez-Ramón, MD, PhD, Jesús Fuentes-Antrás, MD, Nicholas L. Rider, MD, Pedro Pérez-Segura, MD, PhD, Eduardo de la Fuente-Muñoz, MD, Miguel Fernández-Arquero, PhD, Esmeralda Neves, MD, Rebeca Pérez de Diego, PhD, Alberto Ocaña, MD, PhD, Kissy Guevara-Hoyer, MD, PhD
Publikováno v:
Journal of Allergy and Clinical Immunology: Global, Vol 3, Iss 2, Pp 100203- (2024)
Background: Gastric cancer (GC) stands as a prominent cause of cancer-related mortality and ranks second among the most frequently diagnosed malignancies in individuals with common variable immunodeficiency (CVID). Objective: We sought to conduct a c
Externí odkaz:
https://doaj.org/article/999d1c18df1e4ce0b69c419d841eeff7
Anti-EGFR conjugated nanoparticles to deliver Alpelisib as targeted therapy for head and neck cancer
Autor:
Alberto Juan, Carmen Segrelles, Almudena del Campo-Balguerías, Iván Bravo, Ignacio Silva, Jorge Peral, Alberto Ocaña, Pilar Clemente-Casares, Carlos Alonso-Moreno, Corina Lorz
Publikováno v:
Cancer Nanotechnology, Vol 14, Iss 1, Pp 1-21 (2023)
Abstract Background Head and neck squamous cell carcinoma (SCC) is one of the most prevalent and deadly cancers worldwide. Even though surgical approaches, radiation therapy, and therapeutic agents are commonly used, the prognosis of this cancer rema
Externí odkaz:
https://doaj.org/article/4562f481a10d4ac7b0d1dc2f56652103
Autor:
Cristina Nieto‐Jiménez, Adrián Sanvicente, Cristina Díaz‐Tejeiro, Víctor Moreno, Alfonso lopez deSá, Emiliano Calvo, Joaquín Martínez‐López, Pedro Pérez‐Segura, Alberto Ocaña
Publikováno v:
Clinical and Translational Medicine, Vol 13, Iss 9, Pp n/a-n/a (2023)
Abstract Introduction Antibody‐drug conjugates (ADCs) are a family of therapeutic agents that have demonstrated clinical activity in several indications. Material and methods In this article, we performed a deep analysis of their clinical landscape
Externí odkaz:
https://doaj.org/article/445511a833964204a594eaf0a23f9c5e
Autor:
Esther Cabañas Morafraile, Cristina Saiz-Ladera, Cristina Nieto-Jiménez, Balázs Győrffy, Adam Nagy, Guillermo Velasco, Pedro Pérez-Segura, Alberto Ocaña
Publikováno v:
Current Oncology, Vol 30, Iss 3, Pp 2569-2581 (2023)
Despite the impressive results obtained with immunotherapy in several cancer types, a significant fraction of patients remains unresponsive to these treatments. In colorectal cancer (CRC), B-RafV600 mutations have been identified in 8–15% of the pa
Externí odkaz:
https://doaj.org/article/e41c2709dfde49eaa725839de2ad6b27
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 41, Iss 1, Pp 1-26 (2022)
Abstract The HER3 protein, that belongs to the ErbB/HER receptor tyrosine kinase (RTK) family, is expressed in several types of tumors. That fact, together with the role of HER3 in promoting cell proliferation, implicate that targeting HER3 may have
Externí odkaz:
https://doaj.org/article/ab1e967dfa2146b59981aefb16f60db2
Autor:
Adrián Sánchez‐Fdez, Sofía Matilla‐Almazán, Juan Carlos Montero, Sofía Del Carmen, Mar Abad, Sara García‐Alonso, Somshuvra Bhattacharya, Kristin Calar, Pilar de la Puente, Alberto Ocaña, Atanasio Pandiella, Azucena Esparís‐Ogando
Publikováno v:
Clinical and Translational Medicine, Vol 13, Iss 4, Pp n/a-n/a (2023)
Abstract Background The dismal prognosis of advanced ovarian cancer calls for the development of novel therapies to improve disease outcome. In this regard, we set out to discover new molecular entities and to assess the preclinical effectiveness of
Externí odkaz:
https://doaj.org/article/f594c2dfb3ea40f9b09fd0e75cb500ec
Autor:
Syong H. Nam-Cha, Elena Domínguez-Jurado, Selena L. Tinoco-Valencia, Ramón Pérez-Tanoira, Noelia Morata-Moreno, Rocío Alfaro-Ruiza, Agustín Lara-Sánchez, Jaime Esteban, Rafael Luján, Carlos Alonso-Moreno, Pedro Seguí, Alberto Ocaña, Ángel López Gónzalez, John J. Aguilera-Correa, Francisco C. Pérez-Martínez, Milagros Molina Alarcón
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 13 (2023)
Staphylococcus aureus is one of the species with the greatest clinical importance and greatest impact on public health. In fact, methicillin-resistant S. aureus (MRSA) is considered a pandemic pathogen, being essential to develop effective medicines
Externí odkaz:
https://doaj.org/article/d4a2875e0d204087b3f8db161c84d89f
Publikováno v:
Molecular Cancer, Vol 21, Iss 1, Pp 1-9 (2022)
Abstract Degradation of targeted proteins using proteolysis targeting chimeras (PROTACs) has gained momentum. A PROTAC is a bifunctional molecule that consists of three parts: a ligand that interacts with the protein to be degraded, another ligand th
Externí odkaz:
https://doaj.org/article/bb12255a4c6143919596c5fcbb92f31e
Autor:
Juan Carlos Montero, Elisa Calvo-Jiménez, Sofía del Carmen, Mar Abad, Alberto Ocaña, Atanasio Pandiella
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 41, Iss 1, Pp 1-16 (2022)
Abstract Background Despite the incorporation of novel therapeutics, advanced triple negative breast cancer (TNBC) still represents a relevant clinical problem. Considering this, as well as the clinical efficacy of antibody-drug conjugates (ADCs), we
Externí odkaz:
https://doaj.org/article/4f993c2abfac46199a9b964282d2c6f6