Structural Landscape of the Transition from an ssDNA Dumbbell Plus Its Complementary Hairpin to a dsDNA Microcircle Via a Kissing Loop Intermediate

Autor: Alberto Mills, Federico Gago

Publikováno v: Molecules, Vol 26, Iss 10, p 3017 (2021)

The experimental construction of a double-stranded DNA microcircle of only 42 base pairs entailed a great deal of ingenuity and hard work. However, figuring out the three-dimensional structures of intermediates and the final product can be particular

Externí odkaz: https://doaj.org/article/936fd9499ab44fe292a336991f078843

(F)uridylylated Peptides Linked to VPg1 of Foot-and- Mouth Disease Virus (FMDV): Design, Synthesis and X-Ray Crystallography of the Complexes with FMDV RNA-Dependent RNA Polymerase

Autor: Sonia de Castro, Cristina Ferrer-Orta, Alberto Mills, Gloria Fernández-Cureses, Federico Gago, Nuria Verdaguer, María-José Camarasa

Publikováno v: Molecules, Vol 24, Iss 13, p 2360 (2019)

Foot-and-mouth disease virus (FMDV) is an RNA virus belonging to the Picornaviridae family that contains three small viral proteins (VPgs), named VPg1, VPg2 and VPg3, linked to the 5′-end of the viral genome. These VPg proteins act as primers for R

Externí odkaz: https://doaj.org/article/e58f0e81ac424096b72ccc2fa27f76ca

Structural and mechanistic insight into DNA bending by antitumour calicheamicins

Autor: Alberto Mills, Federico Gago

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname

Among the class of enediyne antibiotics endowed with potent antitumour activities, the calicheamicin derivative known as ozogamicin is selectively targeted to several leukaemia cell types by means of tailor-made immunoconjugates. Binding of these dru

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0af0b2723dedf8d283969a8d58bfda8
https://pubmed.ncbi.nlm.nih.gov/34297027

The structure and flexibility analysis of the

Autor: Juan L, Benavente, Dritan, Siliqi, Lourdes, Infantes, Laura, Lagartera, Alberto, Mills, Federico, Gago, Noemí, Ruiz-López, Miguel A, Botella, María J, Sánchez-Barrena, Armando, Albert

Publikováno v: Life Science Alliance

Plant SYT1 transports lipids between endoplasmic reticulum and plasma membrane in response to stress. The protein flexibility and lipid-binding specificity determine SYT1 function at molecular level.
Non-vesicular lipid transfer at ER and plasma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2d0ccf7f078a02446feb02a4b0eb62fb
https://pubmed.ncbi.nlm.nih.gov/34408000

The structure and flexibility analysis of the Arabidopsis Synaptotagmin 1 reveal the basis of its regulation at membrane contact sites

Autor: Noemi Ruiz-Lopez, María José Sánchez-Barrena, Dritan Siliqi, Armando Albert, Alberto Mills, Laura Lagartera, Federico Gago, Juan Luis Benavente, Lourdes Infantes, Miguel A. Botella

Publikováno v: EMBO journal (Online) 4 (2021). doi:10.26508/LSA.202101152
info:cnr-pdr/source/autori:Benavente J.L.; Siliqi D.; Infantes L.; Lagartera L.; Mills A.; Gago F.; Ruiz-Lopez N.; Botella M.A.; Sanchez-Barrena M.J.; Albert A./titolo:The structure and flexibility analysis of the Arabidopsis synaptotagmin 1 reveal the basis of its regulation at membrane contact sites/doi:10.26508%2FLSA.202101152/rivista:EMBO journal (Online)/anno:2021/pagina_da:/pagina_a:/intervallo_pagine:/volume:4
Digital.CSIC. Repositorio Institucional del CSIC
instname

17 pags., 7 figs., 1 tab.
Non-vesicular lipid transfer at ER and plasma membrane (PM) contact sites (CS) is crucial for the maintenance of membrane lipid homeostasis. Extended synaptotagmins (E-Syts) play a central role in this process as they a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::306f2fc8fc14ef3dfc1ca123b3d965d9
https://doi.org/10.1101/2021.04.09.438084