Zobrazeno 1 - 10 of 90 pro vyhledávání: '"Alberto Marini"'
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Akademický článek
MYC up-regulation confers vulnerability to dual inhibition of CDK12 and CDK13 in high-risk Group 3 medulloblastoma
Autor: Consuelo Pitolli, Alberto Marini, Marika Guerra, Marco Pieraccioli, Veronica Marabitti, Fernando Palluzzi, Luciano Giacò, Gianpiero Tamburrini, Francesco Cecconi, Francesca Nazio, Claudio Sette, Vittoria Pagliarini
Publikováno v: Journal of Experimental & Clinical Cancer Research, Vol 42, Iss 1, Pp 1-19 (2023)
Abstract Background Medulloblastoma (MB) is the most common cerebellar malignancy during childhood. Among MB, MYC-amplified Group 3 tumors display the worst prognosis. MYC is an oncogenic transcription factor currently thought to be undruggable. Neve
Externí odkaz: https://doaj.org/article/030743204b074a1299f471eeca329a4b
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2
Akademický článek
The pathogenesis of mesothelioma is driven by a dysregulated translatome
Autor: Stefano Grosso, Alberto Marini, Katarina Gyuraszova, Johan Vande Voorde, Aristeidis Sfakianos, Gavin D. Garland, Angela Rubio Tenor, Ryan Mordue, Tanya Chernova, Nobu Morone, Marco Sereno, Claire P. Smith, Leah Officer, Pooyeh Farahmand, Claire Rooney, David Sumpton, Madhumita Das, Ana Teodósio, Catherine Ficken, Maria Guerra Martin, Ruth V. Spriggs, Xiao-Ming Sun, Martin Bushell, Owen J. Sansom, Daniel Murphy, Marion MacFarlane, John P. C. Le Quesne, Anne E. Willis
Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Treating malignant pleural mesothelioma (MpM) is challenging due to a lack of druggable genes, but other molecular features could be clinically useful. Here the authors profile mRNA translation dysregulation in MpM cell lines using polysome profiling
Externí odkaz: https://doaj.org/article/7e118ded480445418fbb52706c703037
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3
Akademický článek
Non-Canonical Splicing and Its Implications in Brain Physiology and Cancer
Autor: Consuelo Pitolli, Alberto Marini, Claudio Sette, Vittoria Pagliarini
Publikováno v: International Journal of Molecular Sciences, Vol 23, Iss 5, p 2811 (2022)
The advance of experimental and computational techniques has allowed us to highlight the existence of numerous different mechanisms of RNA maturation, which have been so far unknown. Besides canonical splicing, consisting of the removal of introns fr
Externí odkaz: https://doaj.org/article/a07d89e4458343ebb599cf135a0ba45f
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4
Supplementary Figure 4 from Reciprocal Metabolic Reprogramming through Lactate Shuttle Coordinately Influences Tumor-Stroma Interplay
Autor: Paola Chiarugi, Paolo Cirri, Sergio Serni, Michele Lanciotti, Alina De Donatis, Paolo Gandellini, Maria Letizia Taddei, Elisa Giannoni, Alberto Marini, Tania Fiaschi
PDF file - 818K, MCT1 transporter is important for PCa cell growth; A) MCT1 transporter is up-regulated in PCa cells. PCa cells were cultivated alone or in co-colture with CAFs (3:1 CAFs:PCa cells proportion). Cells were then treated with CM-HPFs, CM
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86fa3e4e00df14251b1724bca5f4291e
https://doi.org/10.1158/0008-5472.22395023
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5
Supplementary Figure 2 from Reciprocal Metabolic Reprogramming through Lactate Shuttle Coordinately Influences Tumor-Stroma Interplay
Autor: Paola Chiarugi, Paolo Cirri, Sergio Serni, Michele Lanciotti, Alina De Donatis, Paolo Gandellini, Maria Letizia Taddei, Elisa Giannoni, Alberto Marini, Tania Fiaschi
PDF file - 3.3K, Enrichment of glycolitic enzymes among genes up-regulated in prostatic CAFs; Gene expression profiles were analyzed using an Illumina microarray platform (unpublished data) on paired CAFs and HPFs isolated respectively from the tumor
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26441b188b879c58d32589db2dda889b
https://doi.org/10.1158/0008-5472.22395029
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6
Supplementary Table 1 from Reciprocal Metabolic Reprogramming through Lactate Shuttle Coordinately Influences Tumor-Stroma Interplay
Autor: Paola Chiarugi, Paolo Cirri, Sergio Serni, Michele Lanciotti, Alina De Donatis, Paolo Gandellini, Maria Letizia Taddei, Elisa Giannoni, Alberto Marini, Tania Fiaschi
PDF file - 3MB, Pathological parameters of individuals from which CAFs have isolated; CAFs have been isolated from surgical biopsy from nine individuals with prostate carcinoma. Table reports the pathological parameters of the patients before surgery
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bf3d51843fb3f57606370d583b98d0e
https://doi.org/10.1158/0008-5472.22395020.v1
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7
Supplementary Figure 1 from Reciprocal Metabolic Reprogramming through Lactate Shuttle Coordinately Influences Tumor-Stroma Interplay
Autor: Paola Chiarugi, Paolo Cirri, Sergio Serni, Michele Lanciotti, Alina De Donatis, Paolo Gandellini, Maria Letizia Taddei, Elisa Giannoni, Alberto Marini, Tania Fiaschi
PDF file - 54K, The Biochemical Recurrence (BCR) free survival was estimated using the Kaplan-Meier method; In figure is represented the BCR free survival curve of patients treated with Radical Prostatectomy for Prostate Cancer. Among all, only one p
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b98cb29c73075deb7a99801e7e93623e
https://doi.org/10.1158/0008-5472.22395032.v1
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8
Supplementary Figure 3 from Reciprocal Metabolic Reprogramming through Lactate Shuttle Coordinately Influences Tumor-Stroma Interplay
Autor: Paola Chiarugi, Paolo Cirri, Sergio Serni, Michele Lanciotti, Alina De Donatis, Paolo Gandellini, Maria Letizia Taddei, Elisa Giannoni, Alberto Marini, Tania Fiaschi
PDF file - 385K, 8.Lactate up-load by HPFs and PCa-AFs; 10000 HPFs were treated with serum-free medium or with CM-PCa for 24 hours (PCa-AFs). U-14Clactate were added to the culture media for 30 minutes, then cells were lysated and incorporated radioa
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2856993deba1e97ca024b5248664b3a2
https://doi.org/10.1158/0008-5472.22395026.v1
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10
The pathogenesis of mesothelioma is driven by a dysregulated translatome
Autor: Anne E. Willis, Ana Teodósio, Katarina Gyuraszova, Xiao-Ming Sun, Claire Smith, Ryan Mordue, Marco Sereno, Leah Officer, Claire Rooney, David Sumpton, Pooyeh Farahmand, Angela Rubio Tenor, Owen J. Sansom, Aristeidis P. Sfakianos, Johan Vande Voorde, Maria Guerra Martin, Gavin D. Garland, Madhumita Das, Ruth V. Spriggs, Tanya Chernova, Catherine Ficken, Alberto Marini, Marion MacFarlane, Daniel J. Murphy, Stefano Grosso, Nobu Morone, Martin Bushell, John Le Quesne
Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Nature Communications
Malignant mesothelioma (MpM) is an aggressive, invariably fatal tumour that is causally linked with asbestos exposure. The disease primarily results from loss of tumour suppressor gene function and there are no ‘druggable’ driver oncogenes associ
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4634317d1a5eaacf6a942213133b30e4
https://eprints.gla.ac.uk/248582/1/248582.pdf
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