Local vs. Global Blood Flow Modulation in Artificial Microvascular Networks: Effects on Red Blood Cell Distribution and Partitioning

Autor: Alberto Mantegazza, Matteo Ungari, Francesco Clavica, Dominik Obrist

Publikováno v: Frontiers in Physiology, Vol 11 (2020)

Our understanding of cerebral blood flow (CBF) regulation during functional activation is still limited. Alongside with the accepted role of smooth muscle cells in controlling the arteriolar diameter, a new hypothesis has been recently formulated sug

Externí odkaz: https://doaj.org/article/329133849ce64090b51f257d0b9b5aa0

Effect of Collateral Flow on Catheter-Based Assessment of Cardiac Microvascular Obstruction

Autor: Mirunalini Thirugnanasambandam, Sabrina Frey, Yannick Rösch, Alberto Mantegazza, Francesco Clavica, Robert S. Schwartz, Nikola Cesarovic, Dominik Obrist

Publikováno v: Annals of Biomedical Engineering, 50 (9)
Thirugnanasambandam, Mirunalini; Frey, Sabrina; Rösch, Yannick; Mantegazza, Alberto; Clavica, Francesco; Schwartz, Robert S; Cesarovic, Nikola; Obrist, Dominik (2022). Effect of Collateral Flow on Catheter-Based Assessment of Cardiac Microvascular Obstruction. Annals of biomedical engineering, 50(9), pp. 1090-1102. Springer 10.1007/s10439-022-02985-2

Cardiac microvascular obstruction (MVO) associated with acute myocardial infarction (heart attack) is characterized by partial or complete elimination of perfusion in the myocardial microcirculation. A new catheter-based method (CoFI, Controlled Flow

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b4c6b04fd62544a5430a4d53b8dc4e8
https://doi.org/10.1007/s10439-022-02985-2

In vitro investigations of red blood cell phase separation in a complex microchannel network

Autor: Alberto Mantegazza, Dominik Obrist, Francesco Clavica

Publikováno v: Mantegazza, Alberto; Clavica, Francesco; Obrist, Dominik (2020). In vitro investigations of red blood cell phase separation in a complex microchannel network. Biomicrofluidics, 14(1), 014101. American Institute of Physics 10.1063/1.5127840
Biomicrofluidics

Microvascular networks feature a complex topology with multiple bifurcating vessels. Nonuniform partitioning (phase separation) of red blood cells (RBCs) occurs at diverging bifurcations, leading to a heterogeneous RBC distribution that ultimately af

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6326830cd6b0c7d8310b0bea54625e84
https://boris.unibe.ch/138153/1/Mantegazza2020.pdf