Zobrazeno 1 - 10
of 136
pro vyhledávání: '"Alberto Magi"'
Autor:
Alberto Magi, Gianluca Mattei, Alessandra Mingrino, Chiara Caprioli, Chiara Ronchini, Gianmaria Frigè, Roberto Semeraro, Marta Baragli, Davide Bolognini, Emanuela Colombo, Luca Mazzarella, Pier Giuseppe Pelicci
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract Long-read sequencing allows analyses of single nucleic-acid molecules and produces sequences in the order of tens to hundreds kilobases. Its application to whole-genome analyses allows identification of complex genomic structural-variants (S
Externí odkaz:
https://doaj.org/article/9b134809fa3345dab06c684dc490b0e0
Autor:
Alberto Magi, Gianluca Mattei, Alessandra Mingrino, Chiara Caprioli, Chiara Ronchini, Gianmaria Frigè, Roberto Semeraro, Davide Bolognini, Alessandro Rambaldi, Anna Candoni, Emanuela Colombo, Luca Mazzarella, Pier Giuseppe Pelicci
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-11 (2023)
Abstract Aberrant DNA methylation at CpG dinucleotides is a cancer hallmark that is associated with the emergence of resistance to anti cancer treatment, though molecular mechanisms and biological significance remain elusive. Genome scale methylation
Externí odkaz:
https://doaj.org/article/360db7d9153a44caba3314caf8c15a60
Autor:
Letizia De Chiara, Carolina Conte, Roberto Semeraro, Paula Diaz-Bulnes, Maria Lucia Angelotti, Benedetta Mazzinghi, Alice Molli, Giulia Antonelli, Samuela Landini, Maria Elena Melica, Anna Julie Peired, Laura Maggi, Marta Donati, Gilda La Regina, Marco Allinovi, Fiammetta Ravaglia, Daniele Guasti, Daniele Bani, Luigi Cirillo, Francesca Becherucci, Francesco Guzzi, Alberto Magi, Francesco Annunziato, Laura Lasagni, Hans-Joachim Anders, Elena Lazzeri, Paola Romagnani
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
Acute kidney injury is frequent, often fatal and can leave survivors with chronic kidney disease. Here the authors show that tubular cell polyploidy reduces early fatality sustaining residual function but promotes chronic kidney disease, which can be
Externí odkaz:
https://doaj.org/article/a91d01abb8dc48d881536bd29de595fa
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 23, p 16587 (2023)
The lymphatic vascular system plays a key role in cancer progression. Indeed, the activation of lymphatic endothelial cells (LECs) through the lymphangiogenic process allows for the formation of new lymphatic vessels (LVs) that represent the major ro
Externí odkaz:
https://doaj.org/article/0c3af0b191e7476fac9e268a6d211243
Autor:
Matteo Benelli, Gian Marco Franceschini, Alberto Magi, Dario Romagnoli, Chiara Biagioni, Ilenia Migliaccio, Luca Malorni, Francesca Demichelis
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-15 (2021)
Matteo Benelli et al. present Rocker-meth, a new Hidden Markov Model (HMM)-based method, to robustly identify differentially methylated regions (DMRs). They use Rocker-meth to analyse more than 6000 methylation profiles across 14 cancer types, provid
Externí odkaz:
https://doaj.org/article/2d3834fd736a4fd896630a6f3d833ab9
Publikováno v:
Frontiers in Genetics, Vol 13 (2022)
Single cell RNA sequencing (scRNA-seq) is today a common and powerful technology in biomedical research settings, allowing to profile the whole transcriptome of a very large number of individual cells and reveal the heterogeneity of complex clinical
Externí odkaz:
https://doaj.org/article/0101e74e85b84ee1a320d779344e3f83
Autor:
Alberto Magi, Gianluca Mattei, Alessandra Mingrino, Chiara Caprioli, Chiara Ronchini, Gianmaria Frigè, Roberto Semeraro, Davide Bolognini, Alessandro Rambaldi, Anna Candoni, Emanuela Colombo, Luca Mazzarella, Pier Giuseppe Pelicci
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/50488833a0d4481cbee871921178761d
Autor:
Filippo Martignano, Uday Munagala, Stefania Crucitta, Alessandra Mingrino, Roberto Semeraro, Marzia Del Re, Iacopo Petrini, Alberto Magi, Silvestro G. Conticello
Publikováno v:
Molecular Cancer, Vol 20, Iss 1, Pp 1-6 (2021)
Abstract In the “precision oncology” era the characterization of tumor genetic features is a pivotal step in cancer patients’ management. Liquid biopsy approaches, such as analysis of cell-free DNA from plasma, represent a powerful and noninvas
Externí odkaz:
https://doaj.org/article/8485a2ddff774172b10e1d66802a9ae3
Autor:
Alberto Magi, Tania Giangregorio, Roberto Semeraro, Giulia Carangelo, Flavia Palombo, Giovanni Romeo, Marco Seri, Tommaso Pippucci
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 18, Iss , Pp 1956-1967 (2020)
Runs of Homozygosity (RoHs) are popular among geneticists as the footprint of demographic processes, evolutionary forces and inbreeding in shaping our genome, and are known to confer risk of Mendelian and complex diseases. Notwithstanding growing int
Externí odkaz:
https://doaj.org/article/22e42d5ac86d48238a2b3d78a7ee45e7
Autor:
Davide Bolognini, Alberto Magi
Publikováno v:
Frontiers in Genetics, Vol 12 (2021)
Structural variants (SVs) are genomic rearrangements that involve at least 50 nucleotides and are known to have a serious impact on human health. While prior short-read sequencing technologies have often proved inadequate for a comprehensive assessme
Externí odkaz:
https://doaj.org/article/0dad08f6f6014de693dd7f26a30db70f