Zobrazeno 1 - 10
of 552
pro vyhledávání: '"Alberto Luini"'
Identification and characterization of a new potent inhibitor targeting CtBP1/BARS in melanoma cells
Autor:
Angela Filograna, Stefano De Tito, Matteo Lo Monte, Rosario Oliva, Francesca Bruzzese, Maria Serena Roca, Antonella Zannetti, Adelaide Greco, Daniela Spano, Inmaculada Ayala, Assunta Liberti, Luigi Petraccone, Nina Dathan, Giuliana Catara, Laura Schembri, Antonino Colanzi, Alfredo Budillon, Andrea Rosario Beccari, Pompea Del Vecchio, Alberto Luini, Daniela Corda, Carmen Valente
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 43, Iss 1, Pp 1-32 (2024)
Abstract Background The C-terminal-binding protein 1/brefeldin A ADP-ribosylation substrate (CtBP1/BARS) acts both as an oncogenic transcriptional co-repressor and as a fission inducing protein required for membrane trafficking and Golgi complex part
Externí odkaz:
https://doaj.org/article/1518a1c715734851bf4b6f4560bdaa4e
Autor:
Alberto Luini, Gabriel Farante, Antonio Frasson, Viviana Galimberth, Virgilio Sacchini, Umberto Veronesi
Publikováno v:
Revista Brasileira de Cancerologia, Vol 33, Iss 2 (2023)
Nos últimos 15 anos o tratamento cirúrgico do câncer de mama foi revolucionado por alguns novos conceitos na história natural destes tumores. A impossibilidade de controlar a doença com uma cirurgia alargada, a identificação de tumores cada ve
Externí odkaz:
https://doaj.org/article/ca187a036feb4799880b91f87b9bc8c9
Autor:
Maria Mangini, Maria Antonietta Ferrara, Gianluigi Zito, Stefano Managò, Alberto Luini, Anna Chiara De Luca, Giuseppe Coppola
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 11 (2023)
Circulating tumor cells (CTCs) are tumor cells that have penetrated the circulatory system preserving tumor properties and heterogeneity. Detection and characterization of CTCs has high potential clinical values and many technologies have been develo
Externí odkaz:
https://doaj.org/article/334922f5fb4145fd9daef2a14f24a49c
Autor:
Simona Del Giudice, Valentina De Luca, Seyedehnegar Parizadeh, Domenico Russo, Alberto Luini, Rosaria Di Martino
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
The biosynthetic transport route that constitutes the secretory pathway plays a fundamental role in the cell, providing to the synthesis and transport of around one third of human proteins and most lipids. Signaling molecules within autoregulatory ci
Externí odkaz:
https://doaj.org/article/ce87a23df4c148aa87ff40768e67a91b
Autor:
Andrea Vavassori, Giulia Riva, Iacopo Cavallo, Ruggero Spoto, Samantha Dicuonzo, Cristiana Fodor, Stefania Comi, Raffaella Cambria, Federica Cattani, Anna Morra, Maria Cristina Leonardi, Roberta Lazzari, Mattia Intra, Alberto Luini, Viviana Enrica Galimberti, Paolo Veronesi, Roberto Orecchia, Barbara Jereczek-Fossa
Publikováno v:
Journal of Contemporary Brachytherapy, Vol 12, Iss 3, Pp 207-215 (2020)
Externí odkaz:
https://doaj.org/article/7495b8087542475a9ad4fa2b63075ec8
Autor:
Galina V. Beznoussenko, Andrei Iu. Bejan, Seetharaman Parashuraman, Alberto Luini, Hee-Seok Kweon, Alexander A. Mironov
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 2, p 1375 (2023)
The Golgi complex (GC) is the main station along the cell biosecretory pathway. Until now, mechanisms of intra-Golgi transport (IGT) have remained unclear. Herein, we confirm that the goodness-of-fit of the regression lines describing the exit of a c
Externí odkaz:
https://doaj.org/article/31a2cf18f5054e039d34182471b3111e
Autor:
Alessia Varone, Stefania Mariggiò, Manpreet Patheja, Vincenzo Maione, Antonio Varriale, Mariangela Vessichelli, Daniela Spano, Fabio Formiggini, Matteo Lo Monte, Nadia Brancati, Maria Frucci, Pompea Del Vecchio, Sabato D’Auria, Angela Flagiello, Clara Iannuzzi, Alberto Luini, Piero Pucci, Lucia Banci, Carmen Valente, Daniela Corda
Publikováno v:
Cell Communication and Signaling, Vol 17, Iss 1, Pp 1-21 (2019)
Abstract Background Shp1, a tyrosine-phosphatase-1 containing the Src-homology 2 (SH2) domain, is involved in inflammatory and immune reactions, where it regulates diverse signalling pathways, usually by limiting cell responses through dephosphorylat
Externí odkaz:
https://doaj.org/article/56f9ef9873944b5b84f148cb4d4fd815
Autor:
Diego Tapia, Tomás Jiménez, Constanza Zamora, Javier Espinoza, Riccardo Rizzo, Alexis González-Cárdenas, Danitza Fuentes, Sergio Hernández, Viviana A. Cavieres, Andrea Soza, Fanny Guzmán, Gloria Arriagada, María Isabel Yuseff, Gonzalo A. Mardones, Patricia V. Burgos, Alberto Luini, Alfonso González, Jorge Cancino
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
Inter-organelle signaling coordinates adaptive responses via currently unknown mechanisms. Here, Tapia et al. show that KDEL signaling repositions lysosomes in a complex process termed ‘traffic-induced degradation response for secretion’ (TIDeRS)
Externí odkaz:
https://doaj.org/article/a62da610b52144bab687c355e916d6aa
Autor:
Ilaria Cela, Beatrice Dufrusine, Claudia Rossi, Alberto Luini, Vincenzo De Laurenzi, Luca Federici, Michele Sallese
Publikováno v:
Biomedicines, Vol 10, Iss 6, p 1234 (2022)
KDEL receptors (KDELRs) are ubiquitous seven-transmembrane domain proteins encoded by three mammalian genes. They bind to and retro-transport endoplasmic reticulum (ER)-resident proteins with a C-terminal Lys-Asp-Glu-Leu (KDEL) sequence or variants t
Externí odkaz:
https://doaj.org/article/87e2cba77f7e460796476db480c88f0f
Autor:
Laura Gastaldi, Josefina Inés Martín, Lucas Javier Sosa, Gonzalo Quassollo, Yael Macarena Peralta Cuasolo, Carmen Valente, Alberto Luini, Daniela Corda, Alfredo Cáceres, Mariano Bisbal
Publikováno v:
Cells, Vol 11, Iss 8, p 1320 (2022)
Neurons are highly polarized cells requiring precise regulation of trafficking and targeting of membrane proteins to generate and maintain different and specialized compartments, such as axons and dendrites. Disruption of the Golgi apparatus (GA) sec
Externí odkaz:
https://doaj.org/article/74404149447d4acfb5ecb4bca6ad79cb