Development and Assessment of Herpes Simplex Virus Type 1 (HSV-1) Amplicon Vectors with Sensory Neuron-Selective Promoters

Autor: Charles Joussain, Olivier Le Coz, Andrey Pichugin, Peggy Marconi, Filip Lim, Mariaconcetta Sicurella, Keith Foster, François Giuliano, Alberto L. Epstein, Alejandro Aranda Muñoz

Publikováno v: International Journal of Molecular Sciences, Vol 23, Iss 15, p 8474 (2022)

Background: Neurogenic detrusor overactivity (NDO) is a severe pathological condition characterized by involuntary detrusor contractions leading to urine leakage. This condition is frequent after spinal cord injury (SCI). Gene therapy for NDO require

Externí odkaz: https://doaj.org/article/aa5f0cc84feb4ac8b8957f2b4167f0e4

AAV-mediated neuronal expression of a scFv antibody selective for Aβ oligomers protects synapses and rescues memory in Alzheimer models

Autor: Maria Clara Selles, Juliana T.S. Fortuna, Magali C. Cercato, Luis Eduardo Santos, Luciana Domett, Andre L.B. Bitencourt, Mariane Favero Carraro, Amanda S. Souza, Helena Janickova, Jorge M. de Souza, Soniza Alves-Leon, Vania F. Prado, Marco A. M. Prado, Alberto L. Epstein, Anna Salvetti, Ottavio Arancio, William L. Klein, Adriano Sebollela, Fernanda G. De Felice, Diana A. Jerusalinsky, Sergio T. Ferreira

Brain accumulation of soluble oligomers of the amyloid-β peptide (AβOs) has been implicated in synapse failure and memory impairment in Alzheimer’s disease. Here, we show that treatment with NUsc1, a single-chain variable fragment antibody (scFv)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1c799d8404ca4fad532b4c7c4175c970
https://doi.org/10.1101/2022.06.10.495369

Centrifugal projections to the main olfactory bulb revealed by trans‐synaptic retrograde tracing in mice

Autor: Cécile Viollet, Alexandre Benani, Luc Pénicaud, Alberto L. Epstein, Nanette Y. Schneider, Xavier Grosmaitre, Frédérique Datiche, Sylvie Chaudy, Jean Gascuel

Publikováno v: Journal of Comparative Neurology
Journal of Comparative Neurology, Wiley, 2020, 528 (11), pp.1805-1819. ⟨10.1002/cne.24846⟩
Journal of Comparative Neurology, Wiley, In press
Journal of Comparative Neurology, Wiley, In press, ⟨10.1002/cne.24846⟩
Journal of Comparative Neurology, 2020, 528 (11), pp.1805-1819. ⟨10.1002/cne.24846⟩

A wide range of evidence indicates that olfactory perception is strongly involved in food intake. However, the polysynaptic circuitry linking the brain areas involved in feeding behavior to the olfactory regions is not well known. The aim of this art

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::071c1bb69a8e4536772995e43577e63e
https://hal.inrae.fr/hal-02620936

Maladie d’Alzheimer, neuro-inflammation et virus herpétiques - Une piste qui trace son chemin

Autor: Alberto L, Epstein

Publikováno v: médecine/sciences
médecine/sciences, EDP Sciences, 2020, 36 (5), pp.479-486. ⟨10.1051/medsci/2020090⟩

International audience; Infection of the brain with various types of pathogens, and the resulting inflammatory response, is becoming increasingly important in our understanding of the etiology of Alzheimer's disease (AD). The fact that several genes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::845312d0730f834e28b755d65ef5501f
https://hal.archives-ouvertes.fr/hal-02844099/file/msc200014.pdf

Definition of herpes simplex virus type 1 helper activities for adeno-associated virus early replication events.

Autor: Nathalie Alazard-Dany, Armel Nicolas, Aurélie Ploquin, Regina Strasser, Anna Greco, Alberto L Epstein, Cornel Fraefel, Anna Salvetti

Publikováno v: PLoS Pathogens, Vol 5, Iss 3, p e1000340 (2009)

The human parvovirus Adeno-Associated Virus (AAV) type 2 can only replicate in cells co-infected with a helper virus, such as Adenovirus or Herpes Simplex Virus type 1 (HSV-1); whereas, in the absence of a helper virus, it establishes a latent infect

Externí odkaz: https://doaj.org/article/6cb52e2e462c430c9de3167a1a2ae5aa