Zobrazeno 1 - 10
of 128
pro vyhledávání: '"Alberto Hayek"'
Autor:
Haisong Liu, Ronghui Li, Hsin-Kai Liao, Zheying Min, Chao Wang, Yang Yu, Lei Shi, Jiameng Dan, Alberto Hayek, Llanos Martinez Martinez, Estrella Nuñez Delicado, Juan Carlos Izpisua Belmonte
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
Human pluripotent stem cell (hPSC) derived pancreatic beta cells are a promising and potentially limitless source for cell replacement therapy. Here the authors perform stage-wise chemical screening to develop an improved protocol for hPSC differenti
Externí odkaz:
https://doaj.org/article/e0538b6a302e489391b9de003c23bba8
Publikováno v:
Revista Colombiana de Endocrinología, Diabetes y Metabolismo, Vol -10, Iss 1 (2018)
Se presentan 2 casos de Diabetes Insípida Nefrogénica secundaria a la ingestión de demetil - clor- tetraciclina. El mecanismo de acción de este tipo de Diabetes Insípida parece ser un bloqueo parcial de la acción de la hormona antidiurética en
Externí odkaz:
https://doaj.org/article/98b3768bf1ad47c49b06c60c0ad5d095
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e38721 (2012)
The chemokine receptor CXCR4 and ligand SDF-1α are expressed in fetal and adult mouse islets. Neutralization of CXCR4 has previously been shown to diminish ductal cell proliferation and increase apoptosis in the IFNγ transgenic mouse model in which
Externí odkaz:
https://doaj.org/article/d2ca6eae3e414279a011c467233063b0
Publikováno v:
Cell Transplantation, Vol 9 (2000)
Endocrine cells from the human fetal pancreas will proliferate in vitro on extracellular matrix but lose hormone expression, and redifferentiation requires removal of the expanded cells from the matrix and reaggregation into cell aggregates. However,
Externí odkaz:
https://doaj.org/article/e2d1e36361314e069bad79977847e1f6
Autor:
Sijian Wang, Gillian M. Beattie, Martin I. Mally, Vincenzo Cirulli, Pam Itkin-Ansari, Ana D. Lopez, Alberto Hayek, Fred Levine
Publikováno v:
Cell Transplantation, Vol 6 (1997)
Pancreatic cell lines are useful for basic studies of pancreatic biology and for possible application to cell transplantation therapies for diabetes. A retroviral vector expressing simian virus 40 (SV40) T antigen and H-ras val12 was used to infect a
Externí odkaz:
https://doaj.org/article/16ef3c3df97244e3bb25538b37f2d937
Publikováno v:
Cell Transplantation, Vol 3 (1994)
Islet-like cell clusters generated from human fetal pancreases between 18-24 wk gestation were able to grow and mature both morphologically and functionally after transplantation under the kidney capsule of athymic nude mice. Grafted tissue, predomin
Externí odkaz:
https://doaj.org/article/d5bf8c0f5d7b42ed884308efe407be6f
Publikováno v:
Cell Transplantation, Vol 3 (1994)
We have studied the expression of the β1 family of integrins in fetal and adult human pancreas. Immunohistochemical staining with a monoclonal anti-β1 antibody revealed that the epithelial cells of the human fetal pancreas express high amounts of
Externí odkaz:
https://doaj.org/article/6a03e646c37a4b079eca48dc3a1b78e1
Autor:
Gillian M. Beattie, Alberto Hayek
Publikováno v:
Cell Transplantation, Vol 2 (1993)
In an attempt to demonstrate that a limited β-cell mass is able to maintain normoglycemia in streptozocin-diabetic rats, two groups of inbred rats received transplants of 500 or 1000 neonatal islets (corresponding to 10 and 20% of total islet cell m
Externí odkaz:
https://doaj.org/article/e03a860a5f1443a9a399695131af654a
Autor:
Alberto Hayek, Gillian M. Beattie
Publikováno v:
Cell Transplantation, Vol 1 (1992)
This study was undertaken to evaluate the safety and effectiveness of intravenous (i.v.) injection of islets, via a peripheral vein, in the treatment of experimental diabetes in highly inbred Lewis rats. Rats were made diabetic by the i.v. injection
Externí odkaz:
https://doaj.org/article/5c81b412830a49418730013753c77025
Autor:
Llanos Martinez Martinez, Zheying Min, Alberto Hayek, Haisong Liu, Estrella Nuñez Delicado, Lei Shi, Chao Wang, Ronghui Li, Juan Carlos Izpisua Belmonte, Jiameng Dan, Hsin-Kai Liao, Yang Yu
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
Nature Communications
Nature Communications
Human pluripotent stem cell (hPSC)-derived pancreatic β cells are an attractive cell source for treating diabetes. However, current derivation methods remain inefficient, heterogeneous, and cell line dependent. To address these issues, we first devi