Zobrazeno 1 - 10
of 156
pro vyhledávání: '"Alberto Gabizon"'
Autor:
Alberto Gabizon, Hilary Shmeeda, Benjamin Draper, Ana Parente-Pereira, John Maher, Amaia Carrascal-Miniño, Rafael T. M. de Rosales, Ninh M. La-Beck
Publikováno v:
Pharmaceutics, Vol 15, Iss 11, p 2606 (2023)
Encapsulation of Doxorubicin (Dox), a potent cytotoxic agent and immunogenic cell death inducer, in pegylated (Stealth) liposomes, is well known to have major pharmacologic advantages over treatment with free Dox. Reformulation of alendronate (Ald),
Externí odkaz:
https://doaj.org/article/e363bd6344c14088aaee1897c4370011
Autor:
Hagit Neumann-Raizel, Asaf Shilo, Shaya Lev, Maxim Mogilevsky, Ben Katz, David Shneor, Yoav D. Shaul, Andreas Leffler, Alberto Gabizon, Rotem Karni, Alik Honigman, Alexander M. Binshtok
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
Targeted delivery of therapeutic compounds to particular cell types such that they only affect the target cells is of great clinical importance since it can minimize undesired side effects. For example, typical chemotherapeutic treatments used in the
Externí odkaz:
https://doaj.org/article/5a682d4b168c4f9b80938d081e917a4c
Autor:
Yuval Avnir, Keren Turjeman, Deborah Tulchinsky, Alex Sigal, Pablo Kizelsztein, Dina Tzemach, Alberto Gabizon, Yechezkel Barenholz
Publikováno v:
PLoS ONE, Vol 6, Iss 10, p e25721 (2011)
We report here the design, development and performance of a novel formulation of liposome- encapsulated glucocorticoids (GCs). A highly efficient (>90%) and stable GC encapsulation was obtained based on a transmembrane calcium acetate gradient drivin
Externí odkaz:
https://doaj.org/article/44c7dc348cca484491d1671a0c8e1def
Autor:
Shira Dorot, James Tankel, Victoria Doviner, Hilary Shmeeda, Yasmine Amitay, Patricia Ohana, Amir Dagan, Menachem Ben-Haim, Petachia Reissman, Alberto Gabizon
Publikováno v:
Cancer Chemotherapy and Pharmacology. 90:109-114
To examine the ex- vivo ability of explanted human tumors and normal tissue to activate liposomal mitomycin C lipidic prodrug (MLP) by releasing the active free drug form, mitomycin C (MMC).We tested conversion of MLP to MMC in an ex vivo assay using
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d4ea7163790b027a8692803266ced99
https://doi.org/10.1007/s00280-022-04451-1
https://doi.org/10.1007/s00280-022-04451-1
Autor:
Eli Sapir, Raphael Pfeffer, Marc Wygoda, Ofer Purim, Adi Levy, Benjamin Corn, Yasmine Amitay, Patricia Ohana, Alberto Gabizon
Publikováno v:
International Journal of Radiation Oncology*Biology*Physics.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d5bfcd7a3d00ed67ab16669e9a45056e
https://doi.org/10.1016/j.ijrobp.2023.03.046
https://doi.org/10.1016/j.ijrobp.2023.03.046
Autor:
Alberto Gabizon, Janos Szebeni
Publikováno v:
ACS Nano. 14:7682-7688
In this issue of ACS Nano, Chen et al. provide in vitro and in vivo evidence for monoclonal anti-poly(ethylene glycol) (anti-PEG) antibody-triggered, complement terminal complex-mediated damage to PEGylated liposomal doxorubicin, entailing the releas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1be906d3c39b6f78e1eafa9ec239038
https://doi.org/10.1021/acsnano.0c03648
https://doi.org/10.1021/acsnano.0c03648
Autor:
Hilary Shmeeda, Yasmine Amitay, Alberto Gabizon, Patricia Ohana, Talia Golan, Ravit Geva, Esther Tahover, Ruth Perets
Publikováno v:
Investigational New Drugs. 38:1411-1420
Background Pegylated liposomal (PL) mitomycin-c lipidic prodrug MLP) may be a useful agent in patients with metastatic colo-rectal carcinoma (CRC). We report here on the pharmacokinetics and clinical observations in a phase 1A/B study with PL-MLP. Me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::55854abbb3aa55087e1cc60601321d35
https://doi.org/10.1007/s10637-020-00897-3
https://doi.org/10.1007/s10637-020-00897-3
Publikováno v:
Advanced Drug Delivery Reviews. 158:140-157
Nanoparticles can provide effective control of the release rate and tissue distribution of their drug payload, leading to major pharmacokinetic and pharmacodynamic changes vis-à-vis the conventional administration of free drugs. In the last two deca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad16161786e3fac2741caf87d8f9fa69
https://doi.org/10.1016/j.addr.2020.05.012
https://doi.org/10.1016/j.addr.2020.05.012
Autor:
Yogita Patil, Samuel Zalipsky, Yasmine Amitay, Gleb Kornev, Alberto Gabizon, Esther Tahover, Eli Sapir, Hilary Shmeeda, Patricia Ohana
Publikováno v:
Advanced drug delivery reviews.
Several liposome products have been approved for the treatment of cancer. In all of them, the active agents are encapsulated in the liposome water phase passively or by transmembrane ion gradients. An alternative approach in liposomal drug delivery c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4ebe81149863eac6a342825571c6eac
https://pubmed.ncbi.nlm.nih.gov/32777239
https://pubmed.ncbi.nlm.nih.gov/32777239
Autor:
Ninh M. La-Beck, Laurence M. Wood, Hossein Mansouri, Alberto Gabizon, Manoj K. Sabnani, Robin Rajan, Alexander D. Le, Hilary Shmeeda, Vikram Mavinkurve, Sandrine Bonkoungou
Publikováno v:
Journal of Controlled Release. 271:139-148
Liposomal nanoparticles are the most commonly used drug nano-delivery platforms. However, recent reports show that certain pegylated liposomal nanoparticles (PLNs) and polymeric nanoparticles have the potential to enhance tumor growth and inhibit ant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69e0f5b1a49dd8c85d64cea5de2b111f
https://doi.org/10.1016/j.jconrel.2017.12.023
https://doi.org/10.1016/j.jconrel.2017.12.023