Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Alberto Estevez"'
Autor:
Amy E. Byrnes, Sara L. Dominguez, Chun-Wan Yen, Benjamin I. Laufer, Oded Foreman, Mike Reichelt, Han Lin, Meredith Sagolla, Kathy Hötzel, Hai Ngu, Christoffer Soendergaard, Alberto Estevez, Hsiu-Chao Lin, Alexandre Goyon, Juan Bian, Jessica Lin, Flora I. Hinz, Brad A. Friedman, Amy Easton, Casper C. Hoogenraad
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 32, Iss , Pp 773-793 (2023)
Antisense oligonucleotide (ASO) therapeutics are being investigated for a broad range of neurological diseases. While ASOs have been effective in the clinic, improving productive ASO internalization into target cells remains a key area of focus in th
Externí odkaz:
https://doaj.org/article/3689714968e4460891db8a383fa60cf7
Autor:
Stefan Gerhardy, Mark Ultsch, Wanjian Tang, Evan Green, Jeffrey K. Holden, Wei Li, Alberto Estevez, Chris Arthur, Irene Tom, Alexis Rohou, Daniel Kirchhofer
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
The protease HTRA1 is a genetic risk factor for geographic atrophy. Here, Gerhardy et al. describe its inhibition by a clinical Fab, whose binding locks it in an inactive state. The mechanism identifies an essential function of LoopA with this protea
Externí odkaz:
https://doaj.org/article/55461e6817b145b7b4f3d1b202ec723c
Autor:
Henry R. Maun, Rajesh Vij, Benjamin T. Walters, Ashley Morando, Janet K. Jackman, Ping Wu, Alberto Estevez, Xiaocheng Chen, Yvonne Franke, Michael T. Lipari, Mark S. Dennis, Daniel Kirchhofer, Claudio Ciferri, Kelly M. Loyet, Tangsheng Yi, Charles Eigenbrot, Robert A. Lazarus, James T. Koerber
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
β-tryptases are responsible for most of the proteolytic activity during mast cell activation. Here, the authors develop β-tryptase-inhibiting antibodies and provide structural and biochemical evidence that the bivalency of the antibodies is a prere
Externí odkaz:
https://doaj.org/article/731be2a1b0e94f0d9e6e6bb1c65b39da
Autor:
Yvonne Chen, Maciej Paluch, Julie A. Zorn, Sharmila Rajan, Brandon Leonard, Alberto Estevez, John Brady, Henry Chiu, Wilson Phung, Amin Famili, Minhong Yan, Claudio Ciferri, Marissa L. Matsumoto, Greg A. Lazar, Susan Crowell, Phil Hass, Nicholas J. Agard
Publikováno v:
mAbs, Vol 12, Iss 1 (2020)
Treatment of ocular disease is hindered by the presence of the blood-retinal barrier, which restricts access of systemic drugs to the eye. Intravitreal injections bypass this barrier, delivering high concentrations of drug to the targeted tissue. How
Externí odkaz:
https://doaj.org/article/28ad3cfcdaf4459abab263005b66f32a
Publikováno v:
mAbs, Vol 12, Iss 1 (2020)
The neonatal Fc receptor (FcRn) is a key membrane protein that plays an integral role in serum immunoglobulin (IgG) recycling, which extends the half-life of antibody. In addition, FcRn is known to traffic antigen-bound immunoglobulins (Ag-IgGs), and
Externí odkaz:
https://doaj.org/article/d273eef8179e4d3f97176988e1a9261c
Autor:
Ning Chai, Lee R. Swem, Summer Park, Gerald Nakamura, Nancy Chiang, Alberto Estevez, Rina Fong, Lynn Kamen, Elviza Kho, Mike Reichelt, Zhonghua Lin, Henry Chiu, Elizabeth Skippington, Zora Modrusan, Jeremy Stinson, Min Xu, Patrick Lupardus, Claudio Ciferri, Man-Wah Tan
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-18 (2017)
Influenza B virus (IBV) co-circulates with influenza A virus to cause annual epidemics. Here, Chaiet al. isolate a human monoclonal antibody that binds to a conserved epitope in the viral HA protein, neutralizes IBV strains in vitro, and protects mic
Externí odkaz:
https://doaj.org/article/d697ead9ca194b4d8f53f1f10eadf047
Autor:
Ning Chai, Lee R. Swem, Summer Park, Gerald Nakamura, Nancy Chiang, Alberto Estevez, Rina Fong, Lynn Kamen, Elviza Kho, Mike Reichelt, Zhonghua Lin, Henry Chiu, Elizabeth Skippington, Zora Modrusan, Jeremy Stinson, Min Xu, Patrick Lupardus, Claudio Ciferri, Man-Wah Tan
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-2 (2017)
Nature Communications 8: Article number: 14234 (2017); Published: 19 January 2017; Updated: 25 May 2017 This Article contains errors in Fig. 5c. The blue squares should be labelled ‘Water+46B8’ and the green triangles should be labelled ‘Tamifl
Externí odkaz:
https://doaj.org/article/fd4f9823a247424798f021121a6f98cd
Publikováno v:
ARS Medica, Vol 22, Iss 2, Pp 159-160 (2017)
Sin resumen
Externí odkaz:
https://doaj.org/article/f40cf3b6ea964f9086d1e623278e6cab
Autor:
C. Andrew Boswell, James T. Koerber, Amrita V. Kamath, Simon P. Williams, Lauren Sermeño, Shannon Stainton, Danielle Mandikian, Gregory Z. Ferl, Alberto Estevez, Hanine Rafidi
Supplementary information
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59c17ed013e530bfa711221509fa7caf
https://doi.org/10.1158/1535-7163.22521663.v1
https://doi.org/10.1158/1535-7163.22521663.v1
Data from Imaging Reveals Importance of Shape and Flexibility for Glomerular Filtration of Biologics
Autor:
C. Andrew Boswell, James T. Koerber, Amrita V. Kamath, Simon P. Williams, Lauren Sermeño, Shannon Stainton, Danielle Mandikian, Gregory Z. Ferl, Alberto Estevez, Hanine Rafidi
Advances in antibody engineering have enabled the construction of novel molecular formats in diverse shapes and sizes, providing new opportunities for cancer immunotherapeutic drug discovery while also revealing limitations in knowledge of structure
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5892a7bbcb15fb55b8c79dd6e9f20c8b
https://doi.org/10.1158/1535-7163.c.6543102
https://doi.org/10.1158/1535-7163.c.6543102