Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Alberto Dal Corso"'
Autor:
Lydia Bisbal Lopez, Domenico Ravazza, Matilde Bocci, Aureliano Zana, Lucrezia Principi, Sheila Dakhel Plaza, Andrea Galbiati, Ettore Gilardoni, Jörg Scheuermann, Dario Neri, Luca Pignataro, Cesare Gennari, Samuele Cazzamalli, Alberto Dal Corso
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Immune-stimulating antibody conjugates (ISACs) equipped with imidazoquinoline (IMD) payloads can stimulate endogenous immune cells to kill cancer cells, ultimately inducing long-lasting anticancer effects. A novel ISAC was designed, featuring the IMD
Externí odkaz:
https://doaj.org/article/b9edd8a96d8444cc849c81174ca18bed
Publikováno v:
CHIMIA, Vol 71, Iss 10 (2017)
Cytotoxic drugs, which are commonly used for the pharmacotherapy of many forms of cancer, often cause substantial toxicity to the patient without being able to induce long-lasting remissions. Ligands specific to accessible tumor-associated targets, c
Externí odkaz:
https://doaj.org/article/33efbb17f6a24f6fb25c3db3d2879c24
Herein we describe detailed synthetic procedures and characterization of the presented compounds (i.e., HPLC purity of final products, MS and NMR data, SPR assays), together with additional biological data (i.e., stability of 4a in the presence of Ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1435f9e461c1ee7e8b3cacfb1a18509a
https://doi.org/10.1158/1535-7163.22508968
https://doi.org/10.1158/1535-7163.22508968
Autor:
Giovanni Sacco, Daniela Arosio, Mayra Paolillo, Andreas Gloger, Jörg Scheuermann, Luca Pignataro, Laura Belvisi, Alberto Dal Corso, Cesare Gennari
Publikováno v:
Chemistry-A European Journal, 29 (19)
Salicylaldehyde (SA) derivatives are emerging as useful fragments to obtain reversible-covalent inhibitors interacting with the lysine residues of the target protein. Here the SA installation at the C terminus of an integrin-binding cyclopeptide, lea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::feb3e17944199a3240f1e4a8b4bc561d
https://hdl.handle.net/20.500.11850/604148
https://hdl.handle.net/20.500.11850/604148
Autor:
Tommaso Gandini, Luigi Dolcini, Lorenzo Di Leo, Matthieu Fornara, Alberto Bossi, Marta Penconi, Alberto Dal Corso, Cesare Gennari, Luca Pignataro
Publikováno v:
ChemCatChem. 14
Autor:
Alberto Dal Corso, Margaux Frigoli, Martina Prevosti, Mattia Mason, Raffaella Bucci, Laura Belvisi, Luca Pignataro, Cesare Gennari
Publikováno v:
ChemMedChem. 17(15)
Amine-carbamate self-immolative (SI) spacers represent practical and versatile tools in targeted prodrugs, but their slow degradation mechanism limits drug activation at the site of disease. We engineered a pyrrolidine-carbamate SI spacer with a tert
Autor:
Alberto Dal Corso, Cesare Gennari, Laura Belvisi, Simon Stammwitz, Giovanni Sacco, Luca Pignataro
Publikováno v:
European Journal of Organic Chemistry. 2021:1763-1767
Autor:
Noemi Arrighetti, Simone Arosio, Luca Pignataro, Alberto Dal Corso, Cesare Gennari, Laura Belvisi, Paola Perego
Publikováno v:
Chemical communications (Cambridge, England). 57(63)
Cyclative cleavage of an amine-carbamate self-immolative spacer to deliver a hydroxyl cargo was inhibited by spacer derivatisation with a phosphate monoester handle. This trifunctional spacer was installed in a model anticancer prodrug that showed fa
Publikováno v:
Chemistry – A European Journal. 25:14740-14757
The covalent conjugation of potent cytotoxic agents to either macromolecular carriers or small molecules represents a well-known approach to increase the therapeutic index of these drugs, thus improving treatment efficacy and minimizing side effects.
Autor:
Alberto Dal Corso
Publikováno v:
Chembiochem : a European journal of chemical biology. 21(23)
In recent years, novel classes of small hetero-bifunctional compounds have been developed as tools for the treatment of cancer and other diseases through different approaches, from radio/chemotherapy and imaging to immunotherapy and protein degradati