NDRG1 is induced by antigen-receptor signaling but dispensable for B and T cell self-tolerance

Autor: Rose Hodgson, Xijin Xu, Consuelo Anzilotti, Mukta Deobagkar-Lele, Tanya L. Crockford, Jessica D. Kepple, Eleanor Cawthorne, Aneesha Bhandari, Alberto Cebrian-Serrano, Martin J. Wilcock, Benjamin Davies, Richard J. Cornall, Katherine R. Bull

Publikováno v: Communications Biology, Vol 5, Iss 1, Pp 1-14 (2022)

Despite an upregulation in anergic B cells, N-myc downstream-regulated gene 1 (NDRG1) is not required for the tolerogenic downstream responses, reducing risk of immune modulation on targeting of NDRG1 for cancer therapeutics.

Externí odkaz: https://doaj.org/article/071960c232c647ea9fe3a78b10f61494

Estradiol regulates leptin sensitivity to control feeding via hypothalamic Cited1

Autor: Ismael González-García, Elena García-Clavé, Alberto Cebrian-Serrano, Ophélia Le Thuc, Raian E. Contreras, Yanjun Xu, Tim Gruber, Sonja C. Schriever, Beata Legutko, Jutta Lintelmann, Jerzy Adamski, Wolfgang Wurst, Timo D. Müller, Stephen C. Woods, Paul T. Pfluger, Matthias H. Tschöp, Alexandre Fisette, Cristina García-Cáceres

Publikováno v: Cell metabolism 35(3), 438-455.e7 (2023). doi:10.1016/j.cmet.2023.02.004

Until menopause, women have a lower propensity to develop metabolic diseases than men, suggestive of a protective role for sex hormones. Although a functional synergy between central actions of estrogens and leptin has been demonstrated to protect ag

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ea50ec13163a71892a9a6c287661c81
https://pub.dzne.de/record/256515

Altering the Binding Properties of PRDM9 Partially Restores Fertility across the Species Boundary

Autor: Polinka Hernandez-Pliego, Daniel Biggs, Samy Alghadban, Peter Donnelly, Chris Preece, Daniela Moralli, Gang Zhang, Simon Myers, Philipp W. Becker, Anjali Gupta Hinch, Alberto Cebrian-Serrano, Benjamin Davies

Publikováno v: Molecular Biology and Evolution

Sterility or subfertility of male hybrid offspring is commonly observed. This phenomenon contributes to reproductive barriers between the parental populations, an early step in the process of speciation. One frequent cause of such infertility is a fa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a45d493a79654cfb14178efa104a579e
https://doi.org/10.1093/molbev/msab269

Maternal Supply of Cas9 to Zygotes Facilitates the Efficient Generation of Site-Specific Mutant Mouse Models.

Autor: Alberto Cebrian-Serrano, Shijun Zha, Lars Hanssen, Daniel Biggs, Christopher Preece, Benjamin Davies

Publikováno v: PLoS ONE, Vol 12, Iss 1, p e0169887 (2017)

Genome manipulation in the mouse via microinjection of CRISPR/Cas9 site-specific nucleases has allowed the production time for genetically modified mouse models to be significantly reduced. Successful genome manipulation in the mouse has already been

Externí odkaz: https://doaj.org/article/616fd699410446b8b89450017541961d

A Founder Mutation in

Autor: Naomi Issler, Sara Afonso, Irith Weissman, Katrin Jordan, Alberto Cebrian-Serrano, Katrin Meindl, Eileen Dahlke, Konstantin Tziridis, Guanhua Yan, José M. Robles-López, Lydia Tabernero, Vaksha Patel, Anne Kesselheim, Enriko D. Klootwijk, Horia C. Stanescu, Simona Dumitriu, Daniela Iancu, Mehmet Tekman, Monika Mozere, Graciana Jaureguiberry, Priya Outtandy, Claire Russell, Anna-Lena Forst, Christina Sterner, Elena-Sofia Heinl, Helga Othmen, Ines Tegtmeier, Markus Reichold, Ina Maria Schiessl, Katharina Limm, Peter Oefner, Ralph Witzgall, Lifei Fu, Franziska Theilig, Achim Schilling, Efrat Shuster Biton, Limor Kalfon, Ayalla Fedida, Elite Arnon-Sheleg, Ofer Ben Izhak, Daniella Magen, Yair Anikster, Holger Schulze, Christine Ziegler, Martin Lowe, Benjamin Davies, Detlef Böckenhauer, Robert Kleta, Tzipora C. Falik Zaccai, Richard Warth

Publikováno v: J Am Soc Nephrol
Issler, N, Afonso, S, Weissman, I, Jordan, K, Cebrian-Serrano, A, Meindl, K, Dahlke, E, Tziridis, K, Yan, G, Robles-López, J M, Tabernero, L, Patel, V, Kesselheim, A, Klootwijk, E D, Stanescu, H C, Dumitriu, S, Iancu, D, Tekman, M, Mozere, M, Jaureguiberry, G, Outtandy, P, Russell, C, Forst, A-L, Sterner, C, Heinl, E-S, Othmen, H, Tegtmeier, I, Reichold, M, Schiessl, I M, Limm, K, Oefner, P, Witzgall, R, Fu, L, Theilig, F, Schilling, A, Shuster Biton, E, Kalfon, L, Fedida, A, Arnon-Sheleg, E, Ben Izhak, O, Magen, D, Anikster, Y, Schulze, H, Ziegler, C, Lowe, M, Davies, B, Böckenhauer, D, Kleta, R, Falik Zaccai, T C & Warth, R 2022, ' A Founder Mutation in EHD1 Presents with Tubular Proteinuria and Deafness ', Journal of the American Society of Nephrology : JASN, vol. 33, no. 4, pp. 732-745 . https://doi.org/10.1681/ASN.2021101312

BACKGROUND: The endocytic reabsorption of proteins in the proximal tubule requires a complex machinery and defects can lead to tubular proteinuria. The precise mechanisms of endocytosis and processing of receptors and cargo are incompletely understoo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8d86b9e766f0d768e9b5bfddd01c006
https://pubmed.ncbi.nlm.nih.gov/35256404