Zobrazeno 1 - 10 of 56 pro vyhledávání: '"Alberto Cassetta"'
1
Akademický článek
On the Cholesterol Raising Effect of Coffee Diterpenes Cafestol and 16-O-Methylcafestol: Interaction with Farnesoid X Receptor
Autor: Elena Guercia, Federico Berti, Rita De Zorzi, Luciano Navarini, Silvano Geremia, Barbara Medagli, Marco De Conto, Alberto Cassetta, Cristina Forzato
Publikováno v: International Journal of Molecular Sciences, Vol 25, Iss 11, p 6096 (2024)
The diterpene cafestol represents the most potent cholesterol-elevating compound known in the human diet, being responsible for more than 80% of the effect of coffee on serum lipids, with a mechanism still not fully clarified. In the present study, t
Externí odkaz: https://doaj.org/article/489d9c5423d54c3d8cf7d2c9d71edc48
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2
Akademický článek
Molecular architecture of the glycogen- committed PP1/PTG holoenzyme
Autor: Marta Stefania Semrau, Gabriele Giachin, Sonia Covaceuszach, Alberto Cassetta, Nicola Demitri, Paola Storici, Graziano Lolli
Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
Glycogen metabolism is tightly regulated. Here the authors describe the 3D structure of the PP1/PTG protein complex, which plays a prominent role in the activation of glycogen synthesis and in the pathogenesis of Lafora disease, the most severe form
Externí odkaz: https://doaj.org/article/289b7fe616664ff4b5d17159ee926fb0
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3
Akademický článek
Endogenous modulators of neurotrophin signaling: Landscape of the transient ATP-NGF interactions
Autor: Francesca Paoletti, Franci Merzel, Alberto Cassetta, Iza Ogris, Sonia Covaceuszach, Jože Grdadolnik, Doriano Lamba, Simona Golič Grdadolnik
Publikováno v: Computational and Structural Biotechnology Journal, Vol 19, Iss , Pp 2938-2949 (2021)
The Nerve Growth Factor (NGF) neurotrophin acts in the maintenance and growth of neuronal populations. Despite the detailed knowledge of NGF’s role in neuron physiology, the structural and mechanistic determinants of NGF bioactivity modulated by es
Externí odkaz: https://doaj.org/article/0e69f71ab9aa45d18dd7e75feb7b36e5
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4
Akademický článek
Targeting Siderophore-Mediated Iron Uptake in M. abscessus: A New Strategy to Limit the Virulence of Non-Tuberculous Mycobacteria
Autor: Matteo Mori, Giovanni Stelitano, Giulia Cazzaniga, Arianna Gelain, Andrea Tresoldi, Mario Cocorullo, Martina Roversi, Laurent R. Chiarelli, Martina Tomaiuolo, Pietro Delre, Giuseppe F. Mangiatordi, Anna Griego, Loris Rizzello, Alberto Cassetta, Sonia Covaceuszach, Stefania Villa, Fiorella Meneghetti
Publikováno v: Pharmaceutics, Vol 15, Iss 2, p 502 (2023)
Targeting pathogenic mechanisms, rather than essential processes, represents a very attractive approach for the development of new antimycobacterial drugs. In this context, iron acquisition routes have recently emerged as potentially druggable pathwa
Externí odkaz: https://doaj.org/article/0e262c2fdf194bf3a2bdc22d88bd3f07
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5
Akademický článek
The effect of the pathological V72I, D109N and T190M missense mutations on the molecular structure of α-dystroglycan.
Autor: Sonia Covaceuszach, Manuela Bozzi, Maria Giulia Bigotti, Francesca Sciandra, Petr V Konarev, Andrea Brancaccio, Alberto Cassetta
Publikováno v: PLoS ONE, Vol 12, Iss 10, p e0186110 (2017)
Dystroglycan (DG) is a highly glycosylated protein complex that links the cytoskeleton with the extracellular matrix, mediating fundamental physiological functions such as mechanical stability of tissues, matrix organization and cell polarity. A cruc
Externí odkaz: https://doaj.org/article/6b43a5eebcd049829b84eaa472055bb9
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6
Akademický článek
The Structure of the T190M Mutant of Murine α-Dystroglycan at High Resolution: Insight into the Molecular Basis of a Primary Dystroglycanopathy.
Autor: Manuela Bozzi, Alberto Cassetta, Sonia Covaceuszach, Maria Giulia Bigotti, Saskia Bannister, Wolfgang Hübner, Francesca Sciandra, Doriano Lamba, Andrea Brancaccio
Publikováno v: PLoS ONE, Vol 10, Iss 5, p e0124277 (2015)
The severe dystroglycanopathy known as a form of limb-girdle muscular dystrophy (LGMD2P) is an autosomal recessive disease caused by the point mutation T192M in α-dystroglycan. Functional expression analysis in vitro and in vivo indicated that the m
Externí odkaz: https://doaj.org/article/6b4e257fece54cb2acc7999f7babfe83
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7
Akademický článek
(3R,5S)-5(3)-Carboxy-3,4,5,6-tetrahydro-2H-1,4-thiazin-4-ium-3(5)-carboxylate
Autor: Susanne Heidi Plattner, Marcello Colapietro, Alberto Cassetta, Gustavo Portalone
Publikováno v: Acta Crystallographica Section E, Vol 64, Iss 3, Pp o636-o636 (2008)
The molecule of the zwitterionic title compound, C6H9NO4S, which lies on a mirror plane, shows a puckered chair conformation of the six-membered ring with the S and N atoms out of the mean plane of the other four C atoms by 0.929 (2) and 0.647 (2) Å
Externí odkaz: https://doaj.org/article/ddb130c3cbf9459c9ed7ca1c8bc659d4
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9
Distinct conformational changes occur within the intrinsically unstructured pro-domain of pro-Nerve Growth Factor in the presence of ATP and Mg2
Autor: Francesca Paoletti, Sonia Covaceuszach, Alberto Cassetta, Antonio N. Calabrese, Urban Novak, Petr Konarev, Jože Grdadolnik, Doriano Lamba, Simona Golič Grdadolnik
Publikováno v: Protein science, vol. 32, no. 2, e4563, pp. 1-14, 2023.
Protein Science
Protein science 32(2), e4563 (2023). doi:10.1002/pro.4563
Paoletti, Francesca; Covaceuszach, Sonia; Cassetta, Alberto; Calabrese, Antonio N; Novak, Urban; Konarev, Petr; Grdadolnik, Jože; Lamba, Doriano; Golič Grdadolnik, Simona (2023). Distinct conformational changes occur within the intrinsically unstructured pro-domain of pro-Nerve Growth Factor in the presence of ATP and Mg2. Protein science, 32(2), e4563. Wiley-Blackwell 10.1002/pro.4563
Protein science 32(2), e4563 (2023). doi:10.1002/pro.4563
Nerve growth factor (NGF), the prototypical neurotrophic factor, is involved in the maintenance and growth of specific neuronal populations, whereas its precursor, proNGF, is involved in
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8445c96cd75f3cd076573a1ef57854c4
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10
Distinct conformational changes occur within the intrinsically unstructured pro-domain of pro-Nerve Growth Factor in the presence of ATP and Mg
Autor: Francesca, Paoletti, Sonia, Covaceuszach, Alberto, Cassetta, Antonio N, Calabrese, Urban, Novak, Petr, Konarev, Jože, Grdadolnik, Doriano, Lamba, Simona, Golič Grdadolnik
Publikováno v: Protein science : a publication of the Protein Society.
Nerve Growth Factor (NGF), the prototypical neurotrophic factor, is involved in the maintenance and growth of specific neuronal populations, whereas its precursor, proNGF, is involved in neuronal apoptosis. Binding of NGF or proNGF to TrkA, p75
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1560f047382ce3ec44c49821f4b44585
https://pubmed.ncbi.nlm.nih.gov/36605018
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