Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Alberto C. S. Costa"'
Autor:
Jonah J. Scott-McKean, Ryan Jones, Mark W. Johnson, Joyce Mier, Ines A. Basten, Melissa R. Stasko, Alberto C. S. Costa
Publikováno v:
Brain Sciences, Vol 13, Iss 5, p 743 (2023)
Down syndrome (DS), which results from the complete or partial trisomy of chromosome 21 (trisomy-21), is the most common genetically defined cause of intellectual disability. Trisomy-21 also produces, or is associated with, many neurodevelopmental ph
Externí odkaz:
https://doaj.org/article/f644b1927676431189a22d636eb34274
Autor:
Daniella B. Victorino, Daniel J. L. L. Pinheiro, Jonah J. Scott-McKean, Sarah Barker, Melissa R. Stasko, Jean Faber, Carla A. Scorza, Alberto C. S. Costa
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
Abstract Mounting evidence implicates dysfunctional GABAAR-mediated neurotransmission as one of the underlying causes of learning and memory deficits observed in the Ts65Dn mouse model of Down syndrome (DS). The specific origin and nature of such dys
Externí odkaz:
https://doaj.org/article/5901e46d3ede478a8d1e006e2f931c75
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 15 (2022)
Electrical excitability of cells, tissues and organs is a fundamental phenomenon in biology and physiology. Signatures of excitability include transient currents resulting from a constant or varying voltage gradient across compartments. Interestingly
Externí odkaz:
https://doaj.org/article/02e829a7ccbb446db1fc035ac1e2edbf
Autor:
Anke Hüls, Patrick T. Feany, Sophia Isabella Zisman, Alberto C. S. Costa, Mara Dierssen, Robert Balogh, Stefania Bargagna, Nicole T. Baumer, Ana Claudia Brandão, Angelo Carfi, Brian Allen Chicoine, Sujay Ghosh, Monica Lakhanpaul, Johannes Levin, Yona Lunsky, Coral Manso, Eitan Okun, Diego Real de Asua, Anne-Sophie Rebillat, Tilman R. Rohrer, Giuseppina Sgandurra, Diletta Valentini, Stephanie L. Sherman, Andre Strydom, on behalf of the Trisomy 21 Research Society COVID-19 Initiative
Publikováno v:
Vaccines, Vol 10, Iss 4, p 530 (2022)
Individuals with Down syndrome (DS) are among the groups with the highest risk for severe COVID-19. Better understanding of the efficacy and risks of COVID-19 vaccines for individuals with DS may help improve uptake of vaccination. The T21RS COVID-19
Externí odkaz:
https://doaj.org/article/d9d4e6955ac14d8da9ad6d6233e8f22e
Autor:
Bruna L. Zampieri, Alberto C. S. Costa
Publikováno v:
Brain Sciences, Vol 12, Iss 1, p 83 (2022)
For many decades, neurons have been the central focus of studies on the mechanisms underlying the neurodevelopmental and neurodegenerative aspects of Down syndrome (DS). Astrocytes, which were once thought to have only a passive role, are now recogni
Externí odkaz:
https://doaj.org/article/4d68f98eff8141f4b69bdeaf1bc2dbbd
Autor:
Wenche Stensen, Ulli Rothweiler, Richard Alan Engh, Melissa R. Stasko, Ilya Bederman, Alberto C. S. Costa, Anders Fugelli, John S. Mjøen Svendsen
Publikováno v:
Pharmaceuticals, Vol 14, Iss 11, p 1170 (2021)
Down syndrome (DS) is a complex genetic disorder associated with substantial physical, cognitive, and behavioral challenges. Due to better treatment options for the physical co-morbidities of DS, the life expectancy of individuals with DS is beginnin
Externí odkaz:
https://doaj.org/article/e08484b1821349199632d845ff4f1872
Autor:
David Emes, Anke Hüls, Nicole Baumer, Mara Dierssen, Shiela Puri, Lauren Russell, Stephanie L. Sherman, Andre Strydom, Stefania Bargagna, Ana Cláudia Brandão, Alberto C. S. Costa, Patrick T. Feany, Brian Allen Chicoine, Sujay Ghosh, Anne-Sophie Rebillat, Giuseppina Sgandurra, Diletta Valentini, Tilman R. Rohrer, Johannes Levin, Monica Lakhanpaul, on behalf of the Trisomy 21 Research Society COVID-19 Initiative Study Group
Publikováno v:
Journal of Clinical Medicine, Vol 10, Iss 21, p 5125 (2021)
Adults with Down Syndrome (DS) are at higher risk for severe outcomes of coronavirus disease 2019 (COVID-19) than the general population, but evidence is required to understand the risks for children with DS, which is necessary to inform COVID-19 shi
Externí odkaz:
https://doaj.org/article/7acf1c1480b747f9a9d33147a928cf94
Autor:
James A. Hendrix, David C. Airey, Angela Britton, Anna D. Burke, George T. Capone, Ronelyn Chavez, Jacqueline Chen, Brian Chicoine, Alberto C. S. Costa, Jeffrey L. Dage, Eric Doran, Anna Esbensen, Casey L. Evans, Kelley M. Faber, Tatiana M. Foroud, Sarah Hart, Kelsey Haugen, Elizabeth Head, Suzanne Hendrix, Hampus Hillerstrom, Priya S. Kishnani, Kavita Krell, Duvia Lara Ledesma, Florence Lai, Ira Lott, Cesar Ochoa-Lubinoff, Jennifer Mason, Jessie Nicodemus-Johnson, Nicholas Kyle Proctor, Margaret B. Pulsifer, Carolyn Revta, H. Diana Rosas, Tracie C. Rosser, Stephanie Santoro, Kim Schafer, Thomas Scheidemantel, Frederick Schmitt, Brian G. Skotko, Melissa R. Stasko, Amy Talboy, Amy Torres, Kristi Wilmes, Jason Woodward, Jennifer A. Zimmer, Howard H. Feldman, William Mobley
Publikováno v:
Journal of Clinical Medicine, Vol 10, Iss 9, p 1907 (2021)
With improved healthcare, the Down syndrome (DS) population is both growing and aging rapidly. However, with longevity comes a very high risk of Alzheimer’s disease (AD). The LIFE-DSR study (NCT04149197) is a longitudinal natural history study recr
Externí odkaz:
https://doaj.org/article/b0ea0b58afcb45159ce12d7c51681166
Autor:
Susan K. Kozawa, Audrey Lord, Jonah J. Scott-McKean, Anne Y. Walker, Alberto C. S. Costa, Gary E. Wnek
Publikováno v:
Gels, Vol 7, Iss 2, p 37 (2021)
Poly(acrylic acid) (PAA) bulk gels and threads, typically derived via free-radical polymerization, are of interest as anionic polyelectrolyte mimics of cellular cytosol and as models for early protocells. The thread dimensions have been limited by th
Externí odkaz:
https://doaj.org/article/ce57647a2ff74eb3921a911cb46770fe
Autor:
Jonah J. Scott-McKean, Adriano L. Roque, Krystyna Surewicz, Mark W. Johnson, Witold K. Surewicz, Alberto C. S. Costa
Publikováno v:
Neural Plasticity, Vol 2018 (2018)
The Ts65Dn mouse is the most studied animal model of Down syndrome. Past research has shown a significant reduction in CA1 hippocampal long-term potentiation (LTP) induced by theta-burst stimulation (TBS), but not in LTP induced by high-frequency sti
Externí odkaz:
https://doaj.org/article/de446ed5df69408d9456fc5ed15c7656