Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Alberto B. Alonso"'
Autor:
Richard A. Preston, David Afshartous, Evelyn V. Caizapanta, Barry J. Materson, Rolando Rodco, Eileen Alonso, Alberto B. Alonso
Publikováno v:
Hypertension. 79:813-826
Background: Potassium-induced natriuresis may contribute to the beneficial effects of potassium on blood pressure but has not been well-characterized in human postmenopausal hypertension. We determined the time course and magnitude of potassium-induc
Autor:
Evelyn V. Caizapanta, David Afshartous, Rolando Rodco, Eileen Alonso, Richard A. Preston, Alberto B. Alonso, Barry J. Materson
Publikováno v:
Hypertension. 77:447-460
The thiazide-sensitive sodium-chloride cotransporter (NCC;SLC12A3) is central to sodium and blood pressure regulation. Metabolic syndrome induces NCC upregulation generating sodium-sensitive hypertension in experimental animal models. We tested the r
Publikováno v:
Kidney International. 88:1383-1391
A gastrointestinal-renal kaliuretic signaling axis has been proposed to regulate potassium excretion in response to acute potassium ingestion independent of the extracellular potassium concentration and aldosterone. Here we studied this presumed axis
Autor:
Dyal C. Garg, Zhen Zhao, Richard A. Preston, Caroline Dudkowski, Alberto B. Alonso, Aziz Karim
Publikováno v:
Journal of Clinical Pharmacology
Azilsartan medoxomil (AZL‐M) is a potent angiotensin II receptor blocker that decreases blood pressure in a dose‐dependent manner. It is a prodrug that is not detected in blood after its oral administration because of its rapid hydrolysis to the
Autor:
Adel H. Karara, Vladimir Hanes, Hartmut Blode, Rose Silang, Richard A. Preston, Nagaraju Poola, Alberto B. Alonso, Pingping Ni
Publikováno v:
The Journal of Clinical Pharmacology. 47:1292-1302
The effects of combination hormone therapy of drospirenone (DRSP), a novel progestin with antialdosterone properties, and 17beta-estradiol (E2) on hydrochlorothiazide (HCTZ) pharmacokinetics/pharmacodynamics versus placebo were investigated in a doub
Autor:
Richard A. Preston, Paul M. Norris, Pingping Ni, Alberto B. Alonso, Adel H. Karara, Vladimir Hanes
Publikováno v:
Menopause. 14:408-414
Objective: Drospirenone (DRSP), a spironolactone analog with aldosterone antagonist activity, is a novel progestogen developed for use as hormone therapy in postmenopausal women in combination with 17A-estradiol (E2). DRSP/E2 lowers blood pressure wh
Publikováno v:
American Journal of Hypertension. 15:816-822
Background Aldosterone has been implicated in the pathogenesis of progressive cardiovascular disease. Drospirenone (DRSP) is a novel progestin with aldosterone receptor antagonist activity developed for hormone replacement therapy (HRT) as DRSP/17β-
Publikováno v:
Hypertension (Dallas, Tex. : 1979). 64(2)
Several consistent lines of evidence indicate an association between sodium sensitivity and impaired nitric oxide bioactivity. Nevertheless, whether restoring nitric oxide in humans by pharmacological means can ameliorate sodium sensitivity has not b
Autor:
Richard A. Preston, Alberto B. Alonso, Leonard R. Forte, David Afshartous, Rolando Rodco, Dyal C. Garg, Leopoldo Raij
Publikováno v:
Kidney international. 82(12)
A gastrointestinal–renal natriuretic signaling axis has been proposed to regulate sodium excretion in response to acute sodium ingestion. Such an axis is thought to be regulated by a gastrointestinal sodium sensor coupled to the activation/release
Autor:
David Afshartous, Richard A. Preston, Rolando Rodriguez, Alberto B. Alonso, Sergio Medrano, Dyal C. Garg
Publikováno v:
Hypertension (Dallas, Tex. : 1979). 53(5)
The combination of an aldosterone receptor antagonist added to an angiotensin-converting enzyme inhibitor has been demonstrated to reduce cardiovascular and renal end points in hypertensive humans but can produce hyperkalemia in the common clinical s