Characterization of essential eggshell proteins from Aedes aegypti mosquitoes

Autor: Jun Isoe, Carter J. Simington, Max E. Oscherwitz, Alyssa J. Peterson, Alberto A. Rascón, Brooke B. Massani, Roger L. Miesfeld, Michael A. Riehle

Publikováno v: BMC Biology, Vol 21, Iss 1, Pp 1-24 (2023)

Abstract Background Up to 40% of the world population live in areas where mosquitoes capable of transmitting the dengue virus, including Aedes aegypti, coexist with humans. Understanding how mosquito egg development and oviposition are regulated at t

Externí odkaz: https://doaj.org/article/bfe5d70e980e4c1e9d86bdb4fe977f43

Repurposing auranofin as a lead candidate for treatment of lymphatic filariasis and onchocerciasis.

Autor: Christina A Bulman, Chelsea M Bidlow, Sara Lustigman, Fidelis Cho-Ngwa, David Williams, Alberto A Rascón, Nancy Tricoche, Moses Samje, Aaron Bell, Brian Suzuki, K C Lim, Nonglak Supakorndej, Prasit Supakorndej, Alan R Wolfe, Giselle M Knudsen, Steven Chen, Chris Wilson, Kean-Hooi Ang, Michelle Arkin, Jiri Gut, Chris Franklin, Chris Marcellino, James H McKerrow, Anjan Debnath, Judy A Sakanari

Publikováno v: PLoS Neglected Tropical Diseases, Vol 9, Iss 2, p e0003534 (2015)

Two major human diseases caused by filariid nematodes are onchocerciasis, or river blindness, and lymphatic filariasis, which can lead to elephantiasis. The drugs ivermectin, diethylcarbamazine (DEC), and albendazole are used in control programs for

Externí odkaz: https://doaj.org/article/1872fa3e64e84c4c88486f9960a5d481

Soluble expression of recombinant midgut zymogen (native propeptide) proteases from the Aedes aegypti Mosquito Utilizing E. coli as a host

Autor: Timothy Fong, Daniel Fong, Olive E. Burata, Jonathan Fong, Jamie M. Gallimore, Alberto A. Rascón, Kamille Parungao, James T. Nguyen, Rachael M. Lucero

Publikováno v: BMC Biochemistry
BMC Biochemistry, Vol 19, Iss 1, Pp 1-14 (2018)

Background Studying proteins and enzymes involved in important biological processes in the Aedes aegypti mosquito is limited by the quantity that can be directly isolated from the mosquito. Adding to this difficulty, digestive enzymes (midgut proteas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0e7a8965df7b69b417890026a80849f
https://doi.org/10.1186/s12858-018-0101-0

Phenotypic, chemical and functional characterization of cyclic nucleotide phosphodiesterase 4 (PDE4) as a potential anthelmintic drug target

Autor: Maliwan Meewan, Lin Lin, Fernando Rock, Kurt Jarnagin, Thavy Long, Katherine A. Cunningham, Da Shi, James H. McKerrow, George A. Lemieux, Alberto A. Rascón, Liliana Rojo-Arreola, Larissa M. Podust, Nelly El-Sakkary, Ruben Abagyan, Kaveh Ashrafi, Conor R. Caffrey

Publikováno v: PLoS Neglected Tropical Diseases
PLoS neglected tropical diseases, vol 11, iss 7
Long, T; Rojo-Arreola, L; Shi, D; El-Sakkary, N; Jarnagin, K; Rock, F; et al.(2017). Phenotypic, chemical and functional characterization of cyclic nucleotide phosphodiesterase 4 (PDE4) as a potential anthelmintic drug target. PLoS Neglected Tropical Diseases, 11(7). doi: 10.1371/journal.pntd.0005680. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/37t2q5gm
PLoS Neglected Tropical Diseases, Vol 11, Iss 7, p e0005680 (2017)

Background Reliance on just one drug to treat the prevalent tropical disease, schistosomiasis, spurs the search for new drugs and drug targets. Inhibitors of human cyclic nucleotide phosphodiesterases (huPDEs), including PDE4, are under development a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa394f24515da5f88d2c848a0a1003bb
http://europepmc.org/articles/PMC5526615

[Oropharyngeal dysphagia associated with Chiari I malformation and syringomyelia J]

Autor: Julio César, Cortés-Medina, Armando, Cárdenas-Lara, Carlos Alberto, Guerrero-Rascón, Heber, Rodríguez-Bautista

Publikováno v: Cirugia y cirujanos. 82(3)

Dysphagia associated with neurological disease is an important clinical manifestation in the diagnosis of injury that justifies the compression of the brainstem and lower cranial nerves.To emphasize the study of dysphagia in a patient with Chiari I m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1dbd193c7be17945140ef80259ad09f1
https://pubmed.ncbi.nlm.nih.gov/25238473