Výsledky vyhledávání - "Alberto A. Gabizon"

Akademický článek

Pegylated Liposomal Alendronate Biodistribution, Immune Modulation, and Tumor Growth Inhibition in a Murine Melanoma Model

Autor: Md. Rakibul Islam, Jalpa Patel, Patricia Ines Back, Hilary Shmeeda, Raja Reddy Kallem, Claire Shudde, Maciej Markiewski, William C. Putnam, Alberto A. Gabizon, Ninh M. La-Beck

Publikováno v: Biomolecules, Vol 13, Iss 9, p 1309 (2023)

While tumor-associated macrophages (TAM) have pro-tumoral activity, the ablation of macrophages in cancer may be undesirable since they also have anti-tumoral functions, including T cell priming and activation against tumor antigens. Alendronate is a

Externí odkaz: https://doaj.org/article/57472918f48443b4b323fed7df2955d5

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Akademický článek

Chemo-Radiotherapy of Oligometastases of Colorectal Cancer With Pegylated Liposomal Mitomycin-C Prodrug (Promitil): Mechanistic Basis and Preliminary Clinical Experience

Autor: Esther Tahover, Rachel Bar-Shalom, Eli Sapir, Raphael Pfeffer, Igor Nemirovsky, Yehonatan Turner, Maya Gips, Patricia Ohana, Benjamin W. Corn, Andrew Z. Wang, Alberto A. Gabizon

Publikováno v: Frontiers in Oncology, Vol 8 (2018)

Hypo-fractionated radiotherapy and stereotactic body radiotherapy are viable options for treatment of oligometastases. A prodrug of mitomycin-C is under clinical testing as a pegylated liposomal formulation (Promitil) with an improved safety profile

Externí odkaz: https://doaj.org/article/87f8258574924f4cbea1e191568dfb81

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Abstract A42: Impact of liposomal drug delivery and alendronate co-encapsulation on the immune modulatory effects of doxorubicin in the tumor microenvironment

Autor: Md Rakibul Islam, Jalpa Patel, Patricia Ines Back, Hilary Shmeeda, Konstantin Adamsky, Hui Yang, Carlos Alvarez, Alberto A Gabizon, Ninh M La-Beck

Publikováno v: Cancer Immunology Research. 10:A42-A42

Although Doxorubicin is the standard of care in advanced soft tissue sarcomas, therapeutic efficacy is minimal. A major contributing factor appears to be an immunosuppressive tumor microenvironment (TME). We have shown that liposomal alendronate, an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::925a03ffd5141e996e2dfd4623b4db4c
https://doi.org/10.1158/2326-6074.tumimm22-a42

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Pharmacokinetics of mitomycin-c lipidic prodrug entrapped in liposomes and clinical correlations in metastatic colorectal cancer patients

Autor: Alberto A, Gabizon, Esther, Tahover, Talia, Golan, Ravit, Geva, Ruth, Perets, Yasmine, Amitay, Hilary, Shmeeda, Patricia, Ohana

Publikováno v: Investigational new drugs. 38(5)

Background Pegylated liposomal (PL) mitomycin-c lipidic prodrug MLP) may be a useful agent in patients with metastatic colo-rectal carcinoma (CRC). We report here on the pharmacokinetics and clinical observations in a phase 1A/B study with PL-MLP. Me

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::62d34fa4a7fd6256204fb29dc4b2e767
https://pubmed.ncbi.nlm.nih.gov/31955309

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Controlling Liposomal Drug Release with Low Frequency Ultrasound: Mechanism and Feasibility

Autor: Alberto A. Gabizon, Joseph Kost, Yousef Najajreh, Yechezkel Barenholz, Yeshayahu Talmon, Sarah Weisman, Yuval Avnir, Avi Schroeder

Publikováno v: Langmuir. 23:4019-4025

The ability of low-frequency ultrasound (LFUS) to release encapsulated drugs from sterically stabilized liposomes in a controlled manner was demonstrated. Three liposomal formulations having identical lipid bilayer compositions and a similar size ( a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2867b33bbc0b407c165706846fee7f7
https://doi.org/10.1021/la0631668

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Extensive axillary lymph node involvement in breast cancer patients selected for sentinel lymph node biopsy: incidence and implications

Autor: Ram M. Spira, Eliahu Golomb, Oded Olsha, Oded Zmora, Amiel Segal, Moshe Carmon, Alberto A. Gabizon, Vered Avidan, Meir Goldberg

Publikováno v: Annals of Cancer Research and Therapy. 13:26-28

Extensive axillary lymph node involvement in breast cancer patients implies poor prognosis, and is an indication for chest wall irradiation. Patients presenting with small tumors and a negative axillary status clinically, are expected to have a good

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::69b723800d39d477b1b1f57a132b1693
https://doi.org/10.4993/acrt.13.26

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