Zobrazeno 1 - 10
of 208
pro vyhledávání: '"Alberto Inga"'
Autor:
Jürgen Borlak, Yari Ciribilli, Alessandra Bisio, Saravanakumar Selvaraj, Alberto Inga, Jung-Hwa Oh, Reinhard Spanel
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-34 (2024)
Abstract Background Doxorubicin is an important anticancer drug, however, elicits dose-dependently cardiomyopathy. Given its mode of action, i.e. topoisomerase inhibition and DNA damage, we investigated genetic events associated with cardiomyopathy a
Externí odkaz:
https://doaj.org/article/e2adbab09e374e0287dee8c39f980553
Autor:
Federico Zacchini, Giulia Venturi, Veronica De Sanctis, Roberto Bertorelli, Claudio Ceccarelli, Donatella Santini, Mario Taffurelli, Marianna Penzo, Davide Treré, Alberto Inga, Erik Dassi, Lorenzo Montanaro
Publikováno v:
Genome Biology, Vol 23, Iss 1, Pp 1-27 (2022)
Abstract Background Dyskerin is a nuclear protein involved in H/ACA box snoRNA-guided uridine modification of RNA. In humans, its defective function is associated with cancer development and induces specific post-transcriptional alterations of gene e
Externí odkaz:
https://doaj.org/article/4f5b0ad2ccf74656b5a293ed0e23efa6
Autor:
Vera V. Grinkevich, Aparna Vema, Karin Fawkner, Natalia Issaeva, Virginia Andreotti, Eleanor R. Dickinson, Elisabeth Hedström, Clemens Spinnler, Alberto Inga, Lars-Gunnar Larsson, Anders Karlén, Margareta Wilhelm, Perdita E. Barran, Andrei L. Okorokov, Galina Selivanova, Joanna E. Zawacka-Pankau
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
Restoration of the p53 tumor suppressor for personalised cancer therapy is a promising treatment strategy. However, several high-affinity MDM2 inhibitors have shown substantial side effects in clinical trials. Thus, elucidation of the molecular mecha
Externí odkaz:
https://doaj.org/article/6e3200658e124c519165fca58876e250
Autor:
Samuel Valentini, Caterina Marchioretti, Alessandra Bisio, Annalisa Rossi, Sara Zaccara, Alessandro Romanel, Alberto Inga
Publikováno v:
iScience, Vol 24, Iss 12, Pp 103531- (2021)
Summary: Few studies have explored the association between SNPs and alterations in mRNA translation potential. We developed an approach to identify SNPs that can mark allele-specific protein expression levels and could represent sources of inter-indi
Externí odkaz:
https://doaj.org/article/cd73ba21e26a4248a60c794741c3eafa
Autor:
Martina Rossi, Gabriele Bucci, Dario Rizzotto, Domenico Bordo, Matteo J. Marzi, Margherita Puppo, Arielle Flinois, Domenica Spadaro, Sandra Citi, Laura Emionite, Michele Cilli, Francesco Nicassio, Alberto Inga, Paola Briata, Roberto Gherzi
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Several lncRNAs are regulated by TGF-β. Here the authors report that an intergenic lncRNA —EPR— is a component of the TGF-β signaling pathway and controls epithelial cell proliferation by altering transcription and mRNA decay of Cdkn1a. EPR ove
Externí odkaz:
https://doaj.org/article/d6f7e15deb314cbf950c9b2234270de8
Autor:
Helena Ramos, Maria I.L. Soares, Joana Silva, Liliana Raimundo, Juliana Calheiros, Célia Gomes, Flávio Reis, Filipe A. Monteiro, Cláudia Nunes, Salette Reis, Bartolomeo Bosco, Silvano Piazza, Lucília Domingues, Petr Chlapek, Petr Vlcek, Pavel Fabian, Ana Teresa Rajado, A.T.P. Carvalho, Renata Veselska, Alberto Inga, Teresa M.V.D. Pinho e Melo, Lucília Saraiva
Publikováno v:
Cell Reports, Vol 35, Iss 2, Pp 108982- (2021)
Summary: Impairment of the p53 pathway is a critical event in cancer. Therefore, reestablishing p53 activity has become one of the most appealing anticancer therapeutic strategies. Here, we disclose the p53-activating anticancer drug (3S)-6,7-bis(hyd
Externí odkaz:
https://doaj.org/article/49516e7fa22e429b9dc9fbabff3cfc73
Autor:
Meriem Hadjer Hamadou, Messaoud Kerkatou, Chiara Zucal, Alessandra Bisio, Alessandro Provenzani, Alberto Inga, Ahmed Menad, Samir Benayache, Fadila Benayache, Souad Ameddah
Publikováno v:
Brazilian Archives of Biology and Technology, Vol 64 (2021)
HIGHLIGHTS L. duriusculum n-BuOH extract reduces inflammatory responses both in vitro and in vivo. L. duriusculum n-BuOH extract inhibits NF-κB-dependent transcriptional responses. L. duriusculum n-BuOH extract decreases the expression of TNF-α and
Externí odkaz:
https://doaj.org/article/2a76e5161edb4bacb1299bdeb48c47db
Publikováno v:
Molecular & Cellular Oncology, Vol 7, Iss 5 (2020)
The search for mechanisms underlying different cellular responses to the treatment with Nutlin-3, an MDM2 inhibitor that unleashes p53, revealed a translational control mechanism involving the RNA binding proteins PCBP2 and, particularly, DHX30. Sift
Externí odkaz:
https://doaj.org/article/d3d529f0d6c644efa2dbe0c81e2ddff0
Autor:
Alicja Sznarkowska, Anna Kostecka, Anna Kawiak, Pilar Acedo, Mattia Lion, Alberto Inga, Joanna Zawacka-Pankau
Publikováno v:
Cell Division, Vol 13, Iss 1, Pp 1-12 (2018)
Abstract Background The p73 protein is a tumor suppressor that shares structural and functional similarity with p53. p73 is expressed in two major isoforms; the TA isoform that interacts with p53 pathway, thus acting as tumor suppressor and the N-ter
Externí odkaz:
https://doaj.org/article/2565f0ae0365422295256ca0f89c0535
Autor:
Alicja Sznarkowska, Anna Kostecka, Anna Kawiak, Pilar Acedo, Mattia Lion, Alberto Inga, Joanna Zawacka‑Pankau
Publikováno v:
Cell Division, Vol 14, Iss 1, Pp 1-3 (2019)
The authors note a correction to the article [1]. Figure 1d of the original article has an error. The pcDNA3/Ctrl and the pcDNA3-TAp73a/DMSO wells are duplicated. This article presents the corrected version of Fig. 1.
Externí odkaz:
https://doaj.org/article/23ee66d9f6ef4c21b23e8034af5e4ca5